League game results -- National
Regular season
| Results |
| Date | # | Inn | Away | R | Home | R | Win | Loss | Save | GWRBI |
| 4/1/2021 | | | PUR | 1 | GOT | 5 | Gray,S | Freeland | | Aguilar |
| 4/1/2021 | | | NUT | 14 | CYC | 2 | Bauer | Heaney | | Gallo |
| 4/1/2021 | | | ATK | 6 | SMC | 1 | Fried | Berrios | Karinchak | Votto |
| 4/1/2021 | | | PAN | 4 | NHH | 5 | Quantrill | Watson | | Lewis |
| 4/1/2021 | | | BEA | 6 | PLU | 8 | Bass | Paddack | Scott | Odor |
| 4/1/2021 | | | SEA | 2 | BOM | 6 | deGrom | Bassitt | | Castro,J |
| 4/2/2021 | | | PUR | 4 | GOT | 6 | Kershaw | Canning | Rodriguez,Joe | Gregorius |
| 4/2/2021 | | | NUT | 3 | CYC | 0 | Senzatela | Happ,JA | | Sano |
| 4/2/2021 | | | ATK | 9 | SMC | 2 | Yarbrough | Gonzales | Williams,D | Yastrzemski |
| 4/2/2021 | | | PAN | 1 | NHH | 4 | Urquidy | Duffy | Quantrill | Lewis |
| 4/2/2021 | | 10 | BEA | 5 | PLU | 4 | Fry,P | Rogers,Ty | Rosenthal | Andrus |
| 4/2/2021 | | | SEA | 2 | BOM | 9 | Hendricks | Snell | | |
| 4/3/2021 | | 10 | PUR | 6 | GOT | 5 | Diekman | Baez,P | Jeffress | Gurriel,L |
| 4/3/2021 | | | NUT | 3 | CYC | 4 | Gonzalez,G | Perez,Ma | Pressly | Cabrera,M |
| 4/3/2021 | | | ATK | 0 | SMC | 5 | Walker,T | Montgomery,J | | Anderson,Bri |
| 4/3/2021 | | | PAN | 2 | NHH | 5 | Ynoa | Dunn | Smeltzer | Kipnis |
| 4/3/2021 | | 12 | BEA | 2 | PLU | 3 | Scott | Rosenthal | | Odor |
| 4/3/2021 | | | SEA | 1 | BOM | 10 | Wheeler | Carrasco | | Marte,S |
| 4/4/2021 | | | PAN | 2 | GOT | 3 | Kuhl | Musgrove | Green | Kepler |
| 4/4/2021 | | 14 | ATK | 2 | CYC | 0 | Treinen | Beeks | McGee | Votto |
| 4/4/2021 | | | SEA | 3 | SMC | 5 | Ramirez,No | Bard,D | Melancon | Simmons |
| 4/4/2021 | | | PUR | 4 | PLU | 3 | Ramirez,Y | Peralta,W | Jeffress | Grichuk |
| 4/4/2021 | | | NUT | 5 | BOM | 7 | Urias,J | Javier | Castillo,D | Story |
| 4/4/2021 | | | BEA | 2 | NHH | 9 | Barria | Mize | Allen,L | |
| 4/5/2021 | | | PAN | 4 | GOT | 12 | Margevicius | Lopez,J | | Kepler |
| 4/5/2021 | | | ATK | 2 | CYC | 3 | Means | Skubal | Pressly | Casali |
| 4/5/2021 | | | SEA | 0 | SMC | 2 | Anderson,I | Hill,R | Melancon | Anderson,Bri |
| 4/5/2021 | | 10 | PUR | 8 | PLU | 7 | Jeffress | Zuber | | Belt |
| 4/5/2021 | | | NUT | 2 | BOM | 8 | Houser | Clarke | | Schoop |
| 4/5/2021 | | | BEA | 4 | NHH | 2 | Sanchez,An | Brault | Rosenthal | Cano |
| 4/6/2021 | | | PAN | 0 | GOT | 3 | Alzolay | Matz | Hernandez,J | Arenado |
| 4/6/2021 | | | ATK | 5 | CYC | 6 | Alexander,T | Webb,J | Pressly | Casali |
| 4/6/2021 | | 12 | SEA | 6 | SMC | 5 | Kintzler | Lugo,S | | Alberto |
| 4/6/2021 | | | PUR | 5 | PLU | 6 | Bass | Valdez,P | Garcia,Ja | Soler |
| 4/6/2021 | | | NUT | 1 | BOM | 9 | deGrom | Bauer | | LeMahieu |
| 4/6/2021 | | | BEA | 1 | NHH | 13 | Minor | Paddack | | Conforto |
| 4/7/2021 | | 10 | NHH | 2 | GOT | 3 | Baez,P | Quantrill | | Grisham |
| 4/7/2021 | | | BEA | 3 | CYC | 1 | Jansen,K | Happ,JA | Rosenthal | Cano |
| 4/7/2021 | | | BOM | 3 | SMC | 2 | Hendricks | Gonzales | Colome | Story |
| 4/7/2021 | | | PAN | 0 | PUR | 3 | Canning | Civale | Jeffress | Crawford,B |
| 4/7/2021 | | | NUT | 4 | PLU | 5 | Maeda | Senzatela | Garcia,Ja | Myers |
| 4/7/2021 | | | ATK | 4 | SEA | 5 | Snell | Yarbrough | Kintzler | Lowe,B |
| 4/8/2021 | | | NHH | 4 | GOT | 3 | Kolarek | Gray,S | Quantrill | Conforto |
| 4/8/2021 | | | BEA | 5 | CYC | 10 | Gonzalez,G | Porcello | | Castellanos,N |
| 4/8/2021 | | | BOM | 3 | SMC | 0 | Wheeler | Walker,T | | Schoop |
| 4/8/2021 | | | PAN | 12 | PUR | 9 | Duffy | Ray | | McNeil |
| 4/8/2021 | | | NUT | 3 | PLU | 5 | Davies | Perez,Ma | Rogers,Ty | Odor |
| 4/8/2021 | | | ATK | 3 | SEA | 5 | Carrasco | Montgomery,J | Kintzler | Farmer,K |
| 4/9/2021 | | | NHH | 7 | GOT | 1 | Kolarek | Kershaw | | Stassi |
| 4/9/2021 | | | BEA | 6 | CYC | 5 | Mize | Mills | Rosenthal | Flores,W |
| 4/9/2021 | | 11 | BOM | 10 | SMC | 9 | Hader | Greene | | Goldschmidt |
| 4/9/2021 | | | PAN | 3 | PUR | 2 | Dunn | Webb,L | Watson | Robert |
| 4/9/2021 | | | NUT | 2 | PLU | 6 | Gonsolin | Javier | | Odor |
| 4/9/2021 | | | ATK | 5 | SEA | 7 | Mahle | Tomlin | Bard,D | Goodwin |
| 4/11/2021 | | | GOT | 3 | PUR | 6 | Hudson,Dak | Tanaka | Jeffress | Crawford,B |
| 4/11/2021 | | | CYC | 5 | NUT | 0 | Means | Clarke | Hunter | Castellanos,N |
| 4/11/2021 | | 12 | SMC | 5 | ATK | 4 | Melancon | Treinen | Ramirez,No | Anderson,Bri |
| 4/11/2021 | | | NHH | 7 | PAN | 6 | Farmer,B | Musgrove | Quantrill | Torrens |
| 4/11/2021 | | | PLU | 6 | BEA | 8 | Sanchez,An | Sanchez,S | Pomeranz | Harper,B |
| 4/11/2021 | | | BOM | 8 | SEA | 3 | Houser | Hill,R | Castillo,D | Story |
| 4/12/2021 | | | GOT | 1 | PUR | 2 | Freeland | Kuhl | Jeffress | Crawford,B |
| 4/12/2021 | | | CYC | 7 | NUT | 4 | Heaney | Bauer | Pressly | Castellanos,N |
| 4/12/2021 | | | SMC | 4 | ATK | 5 | Fried | Berrios | Martin,C | Markakis |
| 4/12/2021 | | | NHH | 12 | PAN | 7 | Minor | Lopez,J | | Conforto |
| 4/12/2021 | | | PLU | 2 | BEA | 6 | Paddack | Glasnow | | |
| 4/12/2021 | | | BOM | 6 | SEA | 1 | deGrom | Bassitt | Tate | LeMahieu |
| 4/13/2021 | | | GOT | 3 | PUR | 9 | Canning | Margevicius | | Grichuk |
| 4/13/2021 | | | CYC | 5 | NUT | 3 | Strahm | Bradley,A | Pressly | Ahmed |
| 4/13/2021 | | | SMC | 3 | ATK | 5 | McGee | Matzek | Martin,C | Yastrzemski |
| 4/13/2021 | | | NHH | 6 | PAN | 1 | Urquidy | Matz | | Conforto |
| 4/13/2021 | | 10 | PLU | 4 | BEA | 5 | Lakins | Bass | | Trout |
| 4/13/2021 | | | BOM | 4 | SEA | 8 | Baragar | Hendricks | | Moore |
| 4/14/2021 | | | GOT | 8 | PUR | 7 | Baez,P | Ramirez,Y | Green | Smith,Do |
| 4/14/2021 | | | CYC | 3 | NUT | 2 | Gonzalez,G | Perez,Ma | Pressly | Casali |
| 4/14/2021 | | | SMC | 4 | ATK | 7 | Montgomery,J | Walker,T | Martin,C | Barnhart |
| 4/14/2021 | | | NHH | 2 | PAN | 3 | Civale | Ynoa | Heuer | Robert |
| 4/14/2021 | | | PLU | 2 | BEA | 3 | Thompson | Garcia,B | | Smith,WD |
| 4/14/2021 | | | BOM | 5 | SEA | 0 | Wheeler | Carrasco | | Goldschmidt |
| 4/15/2021 | | | GOT | 5 | ATK | 4 | Gray,S | Tomlin | Green | Kepler |
| 4/15/2021 | | | CYC | 6 | BEA | 8 | Weber | Alexander,T | Lakins | Cano |
| 4/15/2021 | | | SMC | 1 | BOM | 9 | Urias,J | Luzardo | | LeMahieu |
| 4/15/2021 | | | PUR | 3 | PAN | 1 | Webb,L | Duffy | Jeffress | Garver |
| 4/15/2021 | | | PLU | 5 | NHH | 0 | Gonsolin | Barria | Scott | Bregman |
| 4/15/2021 | | | SEA | 5 | NUT | 9 | Javier | Mahle | | Longoria |
| 4/16/2021 | | | GOT | 2 | ATK | 7 | Lorenzen | Kershaw | | Pham |
| 4/16/2021 | | | CYC | 6 | BEA | 3 | Means | Sanchez,An | Almonte,Y | Rosario,E |
| 4/16/2021 | | | SMC | 7 | BOM | 4 | Anderson,I | Houser | Melancon | Abreu,J |
| 4/16/2021 | | | PUR | 6 | PAN | 10 | Dunn | Hudson,Dak | | Moreland |
| 4/16/2021 | | | PLU | 4 | NHH | 9 | Smeltzer | Sanchez,S | | Conforto |
| 4/16/2021 | | | SEA | 7 | NUT | 0 | Hill,R | Clarke | Bard,D | Encarnacion |
| 4/17/2021 | | 11 | GOT | 3 | ATK | 4 | McGee | Hernandez,J | | |
| 4/17/2021 | | 11 | CYC | 12 | BEA | 8 | Pressly | Jansen,K | | Haseley |
| 4/17/2021 | | | SMC | 8 | BOM | 7 | Greene | Hader | Melancon | Anderson,Bri |
| 4/17/2021 | | 10 | PUR | 5 | PAN | 6 | Heuer | Valdez,P | | Garcia,Jo |
| 4/17/2021 | | | PLU | 6 | NHH | 3 | Glasnow | Minor | Garcia,B | Soler |
| 4/17/2021 | | | SEA | 6 | NUT | 1 | Bassitt | Bauer | | Lowe,B |
| 4/18/2021 | | | GOT | 5 | PLU | 0 | Kuhl | Maeda | Green | Laureano |
| 4/18/2021 | | | SMC | 1 | CYC | 4 | Happ,JA | Gonzales | Pressly | Casali |
| 4/18/2021 | | | BOM | 8 | PAN | 1 | Hendricks | Lopez,J | | Goldschmidt |
| 4/18/2021 | | 10 | SEA | 7 | NHH | 4 | Bard,D | Quantrill | Kintzler | Farmer,K |
| 4/18/2021 | | | NUT | 3 | ATK | 7 | Yarbrough | Senzatela | | Franco |
| 4/18/2021 | | | BEA | 0 | PUR | 6 | Canning | Bundy | | Hernandez,T |
| 4/19/2021 | | | GOT | 5 | PLU | 2 | Margevicius | Davies | Green | Nola,Au |
| 4/19/2021 | | | SMC | 4 | CYC | 12 | Gonzalez,G | Walker,T | | Rosario,E |
| 4/19/2021 | | | BOM | 4 | PAN | 3 | Wheeler | Matz | Colome | Story |
| 4/19/2021 | | | SEA | 6 | NHH | 3 | Carrasco | Ynoa | | Encarnacion |
| 4/19/2021 | | | NUT | 1 | ATK | 6 | Montgomery,J | Perez,Ma | | Valaika |
| 4/19/2021 | | | BEA | 4 | PUR | 6 | Ray | Porcello | Jeffress | Belt |
| 4/20/2021 | | | GOT | 1 | PLU | 2 | Gonsolin | Gray,S | Garcia,B | |
| 4/20/2021 | | | SMC | 2 | CYC | 8 | Mills | Luzardo | | Cabrera,M |
| 4/20/2021 | | | BOM | 2 | PAN | 8 | Civale | Urias,J | | Kiner-Falefa |
| 4/20/2021 | | | SEA | 1 | NHH | 7 | Barria | Mahle | | Reyes,V |
| 4/20/2021 | | | NUT | 2 | ATK | 4 | Tomlin | Javier | Martin,C | Votto |
| 4/20/2021 | | | BEA | 7 | PUR | 2 | Mize | Webb,L | | Trout |
| 4/21/2021 | | | GOT | 1 | NHH | 3 | Brault | Hernandez,J | Quantrill | Bote |
| 4/21/2021 | | | BOM | 6 | CYC | 2 | Houser | Means | Tate | Goldschmidt |
| 4/21/2021 | | | SMC | 3 | PUR | 5 | Hudson,Dak | Anderson,I | Jeffress | |
| 4/21/2021 | | | BEA | 12 | PAN | 5 | Sanchez,An | Duffy | | Trout |
| 4/21/2021 | | | PLU | 1 | NUT | 0 | Sanchez,S | Bradley,A | | Myers |
| 4/21/2021 | | | SEA | 8 | ATK | 3 | Kintzler | Skubal | | Perez,Mi |
| 4/22/2021 | | | GOT | 5 | NHH | 2 | Tanaka | Minor | Green | Grisham |
| 4/22/2021 | | | BOM | 0 | CYC | 6 | Heaney | deGrom | | Castellanos,N |
| 4/22/2021 | | | SMC | 3 | PUR | 11 | Freeland | Berrios | | Hernandez,T |
| 4/22/2021 | | | BEA | 2 | PAN | 10 | Dunn | Paddack | | Beaty |
| 4/22/2021 | | | PLU | 3 | NUT | 4 | Bauer | Glasnow | Bradley,A | Calhoun,K |
| 4/22/2021 | | | SEA | 4 | ATK | 6 | Fried | Bassitt | Martin,C | Votto |
| 4/23/2021 | | | GOT | 5 | NHH | 6 | Urquidy | Garrett,A | Quantrill | Margot |
| 4/23/2021 | | | BOM | 9 | CYC | 4 | Hendricks | Happ,JA | | Brosseau |
| 4/23/2021 | | | SMC | 1 | PUR | 3 | Canning | Gonzales | Jeffress | Gurriel,L |
| 4/23/2021 | | | BEA | 8 | PAN | 1 | Bundy | Musgrove | Weber | Trout |
| 4/23/2021 | | | PLU | 6 | NUT | 0 | Maeda | Senzatela | | Odor |
| 4/23/2021 | | | SEA | 8 | ATK | 3 | Snell | Yarbrough | | Lowe,B |
| 4/25/2021 | | 10 | ATK | 8 | GOT | 7 | Williams,D | Johnson,P | Martin,C | Votto |
| 4/25/2021 | | | CYC | 4 | SMC | 18 | Walker,T | Gonzalez,G | Lugo,S | Plawecki |
| 4/25/2021 | | | PAN | 0 | BOM | 8 | Wheeler | Lopez,J | | Dickerson,A |
| 4/25/2021 | | | NHH | 6 | PLU | 7 | Davies | Ynoa | Scott | Soler |
| 4/25/2021 | | | NUT | 2 | SEA | 1 | Dayton | Carrasco | Bradley,A | |
| 4/25/2021 | | | PUR | 7 | BEA | 5 | Staumont | Porcello | Jeffress | Belt |
| 4/26/2021 | | | ATK | 2 | GOT | 4 | Alzolay | Skubal | Green | Aguilar |
| 4/26/2021 | | | CYC | 4 | SMC | 2 | Mills | Luzardo | Pressly | Cabrera,M |
| 4/26/2021 | | | PAN | 11 | BOM | 18 | Urias,J | Matz | | LeMahieu |
| 4/26/2021 | | | NHH | 3 | PLU | 6 | Garcia,Ja | Kolarek | Gibson | DeShields |
| 4/26/2021 | | | NUT | 4 | SEA | 2 | Fairbanks | Kintzler | Bradley,A | Leon |
| 4/26/2021 | | | PUR | 14 | BEA | 12 | Webb,L | Mize | Jeffress | Hernandez,T |
| 4/27/2021 | | | ATK | 14 | GOT | 1 | Fried | Smith,C | | Yastrzemski |
| 4/27/2021 | | | CYC | 8 | SMC | 3 | Means | Anderson,I | Almonte,Y | Gonzalez,E |
| 4/27/2021 | | | PAN | 3 | BOM | 4 | Castillo,D | Wick | Colome | Schoop |
| 4/27/2021 | | | NHH | 7 | PLU | 4 | Smeltzer | Peralta,W | Quantrill | Wendle |
| 4/27/2021 | | | NUT | 4 | SEA | 3 | Crichton | Baragar | Bradley,A | Fletcher,D |
| 4/27/2021 | | | PUR | 5 | BEA | 7 | Sanchez,An | Finnegan | Pomeranz | Harper,B |
| 4/28/2021 | | | PLU | 0 | GOT | 9 | Gray,S | Glasnow | | Aguilar |
| 4/28/2021 | | | CYC | 1 | BOM | 2 | deGrom | Heaney | Hader | Story |
| 4/28/2021 | | | PUR | 6 | SMC | 1 | Freeland | Berrios | | Severino |
| 4/28/2021 | | | PAN | 6 | BEA | 8 | Pomeranz | Heuer | Rosenthal | Trout |
| 4/28/2021 | | | NHH | 8 | SEA | 6 | Minor | Fleming | Quantrill | Margot |
| 4/28/2021 | | 14 | ATK | 5 | NUT | 2 | Martin,C | Crichton | Treinen | Yastrzemski |
| 4/29/2021 | | 16 | PLU | 0 | GOT | 3 | Johnson,P | Scott | | Smith,Do |
| 4/29/2021 | | | CYC | 4 | BOM | 5 | Suter | Pressly | | LeMahieu |
| 4/29/2021 | | | PUR | 3 | SMC | 1 | Brasier | Gonzales | Jeffress | Gurriel,L |
| 4/29/2021 | | | PAN | 4 | BEA | 7 | Bundy | Watson | Lakins | Harper,B |
| 4/29/2021 | | | NHH | 2 | SEA | 8 | Snell | Urquidy | | Arcia |
| 4/29/2021 | | | ATK | 4 | NUT | 1 | Yarbrough | Senzatela | McGee | Votto |
| 4/30/2021 | | | PLU | 5 | GOT | 0 | Davies | Lester | | Bregman |
| 4/30/2021 | | | CYC | 4 | BOM | 5 | Wheeler | Gonzalez,G | Hader | Goldschmidt |
| 4/30/2021 | | | PUR | 0 | SMC | 1 | Matzek | Ramirez,Y | Melancon | Biggio |
| 4/30/2021 | | | PAN | 3 | BEA | 2 | Musgrove | Porcello | Watson | Rosario,A |
| 4/30/2021 | | | NHH | 3 | SEA | 14 | Baragar | Ynoa | Hill,T | Encarnacion |
| 4/30/2021 | | | ATK | 4 | NUT | 2 | Montgomery,J | Perez,Ma | McGee | Pham |
| 5/1/2021 | | | GOT | 6 | CYC | 2 | Margevicius | Anderson,Bre | | Grisham |
| 5/1/2021 | | | NHH | 3 | SMC | 2 | Barria | Gonzales | Quantrill | Hays |
| 5/1/2021 | | 10 | ATK | 2 | PAN | 3 | Sherriff | Martin,C | | Robert |
| 5/1/2021 | | | PLU | 2 | BOM | 3 | Bedrosian | Rogers,Ty | | Winker |
| 5/1/2021 | | | SEA | 2 | BEA | 1 | Mahle | Mize | Kintzler | Ruiz,R |
| 5/1/2021 | | | NUT | 5 | PUR | 4 | Javier | Young,Al | Dayton | Calhoun,K |
| 5/2/2021 | | | GOT | 10 | CYC | 8 | Hernandez,J | Almonte,Y | Green | Aguilar |
| 5/2/2021 | | | NHH | 1 | SMC | 6 | Berrios | Brault | | Plawecki |
| 5/2/2021 | | | ATK | 10 | PAN | 6 | Lorenzen | Matz | Williams,D | Franco |
| 5/2/2021 | | | PLU | 8 | BOM | 1 | Gonsolin | Houser | | Bregman |
| 5/2/2021 | | | SEA | 7 | BEA | 2 | Hill,R | Sanchez,An | | Goodwin |
| 5/2/2021 | | | NUT | 0 | PUR | 6 | Webb,L | Clarke | | La Stella |
| 5/3/2021 | | | GOT | 2 | CYC | 5 | Mills | Gray,S | Pressly | Cabrera,M |
| 5/3/2021 | | | NHH | 4 | SMC | 2 | Minor | Walker,T | Quantrill | |
| 5/3/2021 | | | ATK | 5 | PAN | 1 | Fried | Civale | | Votto |
| 5/3/2021 | | | PLU | 5 | BOM | 13 | deGrom | Glasnow | | Brantley |
| 5/3/2021 | | | SEA | 3 | BEA | 9 | Paddack | Bassitt | | Molina |
| 5/3/2021 | | | NUT | 0 | PUR | 5 | Hudson,Dak | Manaea | | Garver |
| 5/4/2021 | | | JER | 4 | NUT | 2 | Valdez,F | Senzatela | | Candelario |
| 5/4/2021 | | | LAH | 11 | NHH | 5 | May,D | Urquidy | Dolis | Voit |
| 5/4/2021 | | | HOU | 4 | BOM | 2 | Bauer | Hendricks | Foster | Springer |
| 5/4/2021 | | | SCA | 9 | SMC | 4 | Turnbull | Luzardo | Romo | Santana,C |
| 5/4/2021 | | | CCC | 7 | SEA | 8 | Snell | Marquez,G | Fleming | Moore |
| 5/4/2021 | | | ISO | 10 | ATK | 3 | Darvish | Skubal | | Hernandez,En |
| 5/4/2021 | | 12 | LTR | 3 | GOT | 4 | Johnson,P | Garcia,Y | | Nunez,R |
| 5/4/2021 | | | PHS | 9 | CYC | 0 | Arrieta | Heaney | | Haggerty |
| 5/4/2021 | | | WHC | 1 | PLU | 2 | Peralta,W | Sims | Rogers,Ty | Moncada |
| 5/4/2021 | | | JOT | 5 | BEA | 6 | Lakins | Alcala | Rosenthal | Chapman,M |
| 5/4/2021 | | | COL | 6 | PAN | 7 | Duffy | Greinke | Wick | McNeil |
| 5/4/2021 | | | LVB | 5 | PUR | 2 | Anderson,Ty | Freeland | Widener | Jimenez,E |
| 5/5/2021 | | | JER | 1 | NUT | 9 | Perez,Ma | Montas | Crichton | Robles,V |
| 5/5/2021 | | 10 | LAH | 10 | NHH | 8 | Hendriks | Quantrill | | Turner,T |
| 5/5/2021 | | | HOU | 5 | BOM | 1 | Gausman | Wheeler | | |
| 5/5/2021 | | | SCA | 2 | SMC | 6 | Anderson,I | Bubic | Melancon | Plawecki |
| 5/5/2021 | | | CCC | 3 | SEA | 0 | Ryu | Carrasco | | Hernandez,Ce |
| 5/5/2021 | | | ISO | 1 | ATK | 3 | Tomlin | Eovaldi | Martin,C | Yastrzemski |
| 5/5/2021 | | | LTR | 5 | GOT | 3 | Duffey | Hernandez,J | Zimmer,K | Vogelbach |
| 5/5/2021 | | | PHS | 3 | CYC | 5 | Happ,JA | Giolito | Pressly | Rosario,E |
| 5/5/2021 | | | WHC | 3 | PLU | 6 | Davies | Dunning | Rogers,Ty | Varsho |
| 5/5/2021 | | | JOT | 8 | BEA | 5 | Holland,D | Porcello | Castro,M | Cronenworth |
| 5/5/2021 | | | COL | 1 | PAN | 10 | Dunn | Williams,Tr | | White,Ev |
| 5/5/2021 | | | LVB | 2 | PUR | 1 | Stripling | Canning | Stratton | Bichette |
| 5/6/2021 | | | JER | 9 | NUT | 2 | Weaver | Javier | | Happ,I |
| 5/6/2021 | | | LAH | 2 | NHH | 4 | Barria | Woodruff | Quantrill | Wendle |
| 5/6/2021 | | | HOU | 2 | BOM | 3 | Tate | Foster | | Marte,S |
| 5/6/2021 | | | SCA | 7 | SMC | 4 | Romo | Gonzales | Stashak | Bellinger |
| 5/6/2021 | | | CCC | 0 | SEA | 7 | Mahle | Nola,Aa | | Encarnacion |
| 5/6/2021 | | | ISO | 4 | ATK | 6 | Montgomery,J | Wainwright | | Franco |
| 5/6/2021 | | | LTR | 3 | GOT | 6 | Lester | Fiers | | Arenado |
| 5/6/2021 | | | PHS | 4 | CYC | 5 | Hunter | Kinley | Pressly | Rosario,E |
| 5/6/2021 | | | WHC | 7 | PLU | 5 | Suero | McKenzie | Holland,G | Frazier,A |
| 5/6/2021 | | | JOT | 10 | BEA | 4 | Bieber | Mize | | Cronenworth |
| 5/6/2021 | | | COL | 4 | PAN | 5 | Musgrove | Chatwood | Turley | Moreland |
| 5/6/2021 | | | LVB | 3 | PUR | 6 | Ray | Teheran | Jeffress | Grichuk |
| 5/8/2021 | | | NUT | 15 | JER | 7 | Clarke | Junis | | Murphy,D |
| 5/8/2021 | | | NHH | 2 | LAH | 7 | Castillo,L | Brault | | Voit |
| 5/8/2021 | | | BOM | 6 | HOU | 7 | Lamet | Loaisiga | Foster | Tucker,K |
| 5/8/2021 | | 13 | SMC | 9 | SCA | 7 | Melancon | Barnes,M | Greene | Anderson,Bri |
| 5/8/2021 | | | SEA | 3 | CCC | 4 | Diaz,Ed | Bard,D | Hand | Stewart,DJ |
| 5/8/2021 | | | ATK | 6 | ISO | 2 | Yarbrough | Clevinger | Karinchak | |
| 5/8/2021 | | | GOT | 7 | LTR | 8 | Zimmer,K | Barlow | Bummer | Garcia,Av |
| 5/8/2021 | | | CYC | 5 | PHS | 1 | Anderson,Bre | Cueto | Hunter | Ahmed |
| 5/8/2021 | | | PLU | 5 | WHC | 3 | Gonsolin | Voth | Rogers,Ty | DeShields |
| 5/8/2021 | | | BEA | 5 | JOT | 7 | Flaherty | Sanchez,An | Castro,M | Murphy,S |
| 5/8/2021 | | | PAN | 3 | COL | 1 | Lopez,J | Lindblom | Heuer | McNeil |
| 5/8/2021 | | | PUR | 12 | LVB | 5 | Diekman | Widener | | Belt |
| 5/9/2021 | | | NUT | 3 | JER | 2 | Manaea | Singer | Neris | Sano |
| 5/9/2021 | | | NHH | 4 | LAH | 7 | Keuchel | Minor | Hendriks | Merrifield |
| 5/9/2021 | | | BOM | 3 | HOU | 5 | Burnes | deGrom | Foster | Buxton |
| 5/9/2021 | | 11 | SMC | 8 | SCA | 3 | Matzek | Barnes,M | | Anderson,Bri |
| 5/9/2021 | | | SEA | 0 | CCC | 7 | Lynn | Baragar | | Dalbec |
| 5/9/2021 | | | ATK | 5 | ISO | 4 | Williams,D | Raley | Martin,C | Gosselin |
| 5/9/2021 | | | GOT | 5 | LTR | 0 | Baez,P | Peterson,D | | Arenado |
| 5/9/2021 | | | CYC | 4 | PHS | 14 | Arrieta | Garrett,B | | Berti |
| 5/9/2021 | | | PLU | 0 | WHC | 5 | Keller,B | Glasnow | | Jones,JaC |
| 5/9/2021 | | | BEA | 7 | JOT | 6 | Paddack | Bumgarner | Rosenthal | Harper,B |
| 5/9/2021 | | | PAN | 4 | COL | 3 | Wick | Peralta,F | Heuer | Harrison,J |
| 5/9/2021 | | | PUR | 6 | LVB | 5 | Webb,L | Cease | | La Stella |
| 5/10/2021 | | | NUT | 4 | JER | 3 | Senzatela | Valdez,F | Bradley,A | Sano |
| 5/10/2021 | | | NHH | 4 | LAH | 6 | Chapman,A | Urquidy | Hendriks | Ruf |
| 5/10/2021 | | 10 | BOM | 7 | HOU | 8 | Minter | Colome | | Walker,C |
| 5/10/2021 | | | SMC | 6 | SCA | 2 | Loup | Boyd | | Anderson,Bri |
| 5/10/2021 | | | SEA | 3 | CCC | 5 | Marquez,G | Bard,D | Hand | Dalbec |
| 5/10/2021 | | 10 | ATK | 2 | ISO | 3 | Wittgren | Martin,C | | Holt |
| 5/10/2021 | | | GOT | 3 | LTR | 4 | Duffey | Hernandez,J | Bummer | France |
| 5/10/2021 | | | CYC | 10 | PHS | 4 | Norris | Brubaker | Almonte,Y | Bradley,J |
| 5/10/2021 | | | PLU | 5 | WHC | 10 | Plesac | Bass | | Rooker |
| 5/10/2021 | | | BEA | 1 | JOT | 6 | Alcantara,Sa | Bundy | | Diaz,Y |
| 5/10/2021 | | | PAN | 6 | COL | 7 | Peralta,F | Trivino | | Escobar |
| 5/10/2021 | | | PUR | 16 | LVB | 0 | Hudson,Dak | Anderson,Ty | Floro | Belt |
| 5/11/2021 | | | CYC | 4 | GOT | 8 | Smith,C | Heaney | | Engel |
| 5/11/2021 | | | SMC | 0 | NHH | 3 | Farmer,B | Anderson,I | Quantrill | Lewis |
| 5/11/2021 | | | PAN | 3 | ATK | 6 | Tomlin | Duffy | Martin,C | Yastrzemski |
| 5/11/2021 | | | BOM | 2 | PLU | 5 | Peralta,W | Tate | | Cooper |
| 5/11/2021 | | 10 | BEA | 3 | SEA | 4 | Kintzler | Jansen,K | | Ruiz,R |
| 5/11/2021 | | | PUR | 1 | NUT | 5 | Perez,Ma | Freeland | | Longoria |
| 5/12/2021 | | | CYC | 2 | GOT | 1 | Happ,JA | Margevicius | Pressly | Cabrera,M |
| 5/12/2021 | | | SMC | 5 | NHH | 1 | Gonzales | Barria | | Biggio |
| 5/12/2021 | | | PAN | 1 | ATK | 2 | Lorenzen | Dunn | Martin,C | Yastrzemski |
| 5/12/2021 | | | BOM | 0 | PLU | 5 | McKenzie | Urias,J | | Dickerson,C |
| 5/12/2021 | | | BEA | 1 | SEA | 14 | Mahle | Mize | Baragar | Lowe,B |
| 5/12/2021 | | | PUR | 4 | NUT | 3 | Canning | Javier | Jeffress | Hernandez,T |
| 5/13/2021 | | | CYC | 5 | GOT | 2 | Gonzalez,G | Lester | Pressly | Bradley,J |
| 5/13/2021 | | | SMC | 2 | NHH | 7 | Brault | Berrios | Kolarek | Wendle |
| 5/13/2021 | | 10 | PAN | 5 | ATK | 4 | Heuer | Williams,D | | Tapia,R |
| 5/13/2021 | | | BOM | 0 | PLU | 6 | Gonsolin | Houser | | Odor |
| 5/13/2021 | | 10 | BEA | 3 | SEA | 4 | Fleming | Fry,P | | Moore |
| 5/13/2021 | | | PUR | 1 | NUT | 3 | Clarke | Ray | Bradley,A | Newman |
| 5/14/2021 | | 10 | CYC | 5 | GOT | 6 | Smith,WM | Almonte,Y | | Grisham |
| 5/14/2021 | | | SMC | 2 | NHH | 11 | Minor | Walker,T | | Urshela |
| 5/14/2021 | | | PAN | 0 | ATK | 8 | Fried | Lopez,J | | Solak |
| 5/14/2021 | | | BOM | 13 | PLU | 4 | deGrom | Glasnow | | Goldschmidt |
| 5/14/2021 | | | BEA | 4 | SEA | 5 | Bassitt | Paddack | Kintzler | Hosmer |
| 5/14/2021 | | | PUR | 4 | NUT | 2 | Diekman | Dayton | Jeffress | Crawford,B |
| 5/16/2021 | | | GOT | 6 | SEA | 8 | Baragar | Hernandez,J | | Lowe,B |
| 5/16/2021 | | | CYC | 16 | PAN | 2 | Mills | Matz | | Cabrera,M |
| 5/16/2021 | | | BEA | 3 | SMC | 10 | Luzardo | Paddack | | Riley |
| 5/16/2021 | | | PLU | 1 | ATK | 0 | Maeda | Williams,D | Scott | Myers |
| 5/16/2021 | | | BOM | 3 | PUR | 8 | Staumont | Hendricks | | La Stella |
| 5/16/2021 | | | NHH | 0 | NUT | 8 | Senzatela | Urquidy | | Robles,V |
| 5/17/2021 | | | GOT | 5 | SEA | 6 | Carrasco | Margevicius | Baragar | Alberto |
| 5/17/2021 | | | CYC | 5 | PAN | 3 | Heaney | Civale | Pressly | Gurriel,Y |
| 5/17/2021 | | | BEA | 2 | SMC | 4 | Anderson,I | Bundy | | Biggio |
| 5/17/2021 | | | PLU | 2 | ATK | 5 | Tomlin | Davies | Martin,C | Franco |
| 5/17/2021 | | | BOM | 4 | PUR | 6 | Jeffress | Colome | | Belt |
| 5/17/2021 | | | NHH | 0 | NUT | 2 | Perez,Ma | Ynoa | Bradley,A | Calhoun,K |
| 5/18/2021 | | | GOT | 5 | SEA | 6 | Fleming | Hernandez,J | | Braun |
| 5/18/2021 | | | CYC | 5 | PAN | 4 | Happ,JA | Duffy | Pressly | Gurriel,Y |
| 5/18/2021 | | | BEA | 4 | SMC | 6 | Gonzales | Jansen,K | Melancon | Abreu,J |
| 5/18/2021 | | | PLU | 1 | ATK | 2 | Montgomery,J | McKenzie | Martin,C | Franco |
| 5/18/2021 | | | BOM | 8 | PUR | 1 | Urias,J | Freeland | | Winker |
| 5/18/2021 | | | NHH | 5 | NUT | 3 | Barria | Javier | Quantrill | Urshela |
| 5/19/2021 | | | PAN | 3 | GOT | 2 | Dunn | Lester | Heuer | Kiner-Falefa |
| 5/19/2021 | | | CYC | 3 | ATK | 15 | Yarbrough | Gonzalez,G | | Yastrzemski |
| 5/19/2021 | | | SMC | 14 | SEA | 5 | Berrios | Hill,R | Greene | Abreu,J |
| 5/19/2021 | | | PLU | 5 | PUR | 2 | Gonsolin | Canning | | Marte,K |
| 5/19/2021 | | | BOM | 7 | NUT | 3 | Houser | Clarke | Tate | Winker |
| 5/19/2021 | | | BEA | 4 | NHH | 6 | Brault | Mize | | Reyes,V |
| 5/20/2021 | | | PAN | 1 | GOT | 8 | Alzolay | Musgrove | | Aguilar |
| 5/20/2021 | | | CYC | 1 | ATK | 5 | Fried | Anderson,Bre | | McCann |
| 5/20/2021 | | | SMC | 5 | SEA | 1 | Walker,T | Bassitt | Melancon | Grossman |
| 5/20/2021 | | | PLU | 11 | PUR | 12 | Valdez,P | Rogers,Ty | | Severino |
| 5/20/2021 | | | BOM | 9 | NUT | 5 | deGrom | Manaea | Castillo,D | Story |
| 5/20/2021 | | | BEA | 7 | NHH | 11 | Minor | Sanchez,An | | Margot |
| 5/21/2021 | | | PAN | 8 | GOT | 1 | Lopez,J | Tanaka | Turley | Harrison,J |
| 5/21/2021 | | | CYC | 5 | ATK | 6 | Skubal | Mills | Martin,C | Gonzalez,M |
| 5/21/2021 | | 10 | SMC | 3 | SEA | 2 | Matzek | Baragar | Melancon | Kendrick |
| 5/21/2021 | | | PLU | 5 | PUR | 6 | Diekman | Scott | Jeffress | Crawford,B |
| 5/21/2021 | | | BOM | 2 | NUT | 9 | Senzatela | Hendricks | | Murphy,D |
| 5/21/2021 | | | BEA | 3 | NHH | 8 | Urquidy | Paddack | | Lewis |
| 5/22/2021 | | | BEA | 5 | GOT | 2 | Bundy | Garrett,A | Rosenthal | Molina |
| 5/22/2021 | | | CYC | 4 | SEA | 2 | Heaney | Fleming | Pressly | Gonzalez,E |
| 5/22/2021 | | | SMC | 2 | NUT | 0 | Anderson,I | Perez,Ma | | Anderson,Bri |
| 5/22/2021 | | | PLU | 11 | PAN | 2 | Davies | Matz | | Bregman |
| 5/22/2021 | | | BOM | 6 | ATK | 4 | Wheeler | Tomlin | Hader | Goldschmidt |
| 5/22/2021 | | | PUR | 7 | NHH | 8 | Quantrill | Ramirez,Y | | Reyes,V |
| 5/23/2021 | | | BEA | 1 | GOT | 6 | Smith,C | Porcello | | Kepler |
| 5/23/2021 | | | CYC | 6 | SEA | 4 | Happ,JA | Mahle | Pressly | Castellanos,N |
| 5/23/2021 | | | SMC | 0 | NUT | 4 | Crichton | Gonzales | | Longoria |
| 5/23/2021 | | | PLU | 6 | PAN | 2 | McKenzie | Civale | Bass | Myers |
| 5/23/2021 | | | BOM | 5 | ATK | 6 | Montgomery,J | Urias,J | Martin,C | Valaika |
| 5/23/2021 | | | PUR | 3 | NHH | 1 | Hudson,Dak | Barria | Jeffress | Grichuk |
| 5/24/2021 | | | BEA | 2 | GOT | 4 | Kershaw | Mize | Green | Edman |
| 5/24/2021 | | | CYC | 3 | SEA | 12 | Stammen | Gonzalez,G | | Ruiz,R |
| 5/24/2021 | | | SMC | 5 | NUT | 6 | Bradley,A | Loup | | Gimenez |
| 5/24/2021 | | | PLU | 4 | PAN | 1 | Gonsolin | Duffy | Scott | Dickerson,C |
| 5/24/2021 | | 12 | BOM | 7 | ATK | 5 | Colome | Graterol | | Winker |
| 5/24/2021 | | | PUR | 2 | NHH | 8 | Brault | Freeland | | Conforto |
| 5/26/2021 | | | GOT | 1 | PAN | 2 | Dunn | Gray,S | Heuer | Rosario,A |
| 5/26/2021 | | | ATK | 6 | CYC | 2 | Fried | Anderson,Bre | | McCann |
| 5/26/2021 | | | SEA | 3 | SMC | 4 | Greene | Bassitt | Melancon | Anderson,Bri |
| 5/26/2021 | | | PUR | 4 | PLU | 7 | Glasnow | Canning | Rogers,Ty | Marte,K |
| 5/26/2021 | | | NUT | 0 | BOM | 5 | deGrom | Manaea | | Brosseau |
| 5/26/2021 | | | NHH | 5 | BEA | 7 | Weber | Tepera | Jansen,K | Trout |
| 5/27/2021 | | | GOT | 5 | PAN | 3 | Margevicius | Musgrove | Green | Nola,Au |
| 5/27/2021 | | 13 | ATK | 4 | CYC | 3 | Martin,C | Strahm | McGee | Pham |
| 5/27/2021 | | | SEA | 4 | SMC | 2 | Snell | Luzardo | Kintzler | Alberto |
| 5/27/2021 | | | PUR | 11 | PLU | 5 | Finnegan | Maeda | | Hernandez,T |
| 5/27/2021 | | | NUT | 3 | BOM | 8 | Hendricks | Senzatela | | Goldschmidt |
| 5/27/2021 | | | NHH | 1 | BEA | 3 | Paddack | Urquidy | | Chapman,M |
| 5/28/2021 | | | GOT | 7 | PAN | 0 | Kuhl | Lopez,J | | Nunez,R |
| 5/28/2021 | | | ATK | 5 | CYC | 9 | Heaney | Tomlin | | Gurriel,Y |
| 5/28/2021 | | | SEA | 0 | SMC | 6 | Anderson,I | Carrasco | | Kendrick |
| 5/28/2021 | | | PUR | 11 | PLU | 3 | Young,Al | Davies | Diekman | Crawford,B |
| 5/28/2021 | | | NUT | 2 | BOM | 4 | Wheeler | Perez,Ma | | Winker |
| 5/28/2021 | | | NHH | 7 | BEA | 9 | Weber | Ynoa | Rosenthal | Chapman,M |
| 5/29/2021 | | | GOT | 6 | BEA | 5 | Tanaka | Porcello | Green | Nola,Au |
| 5/29/2021 | | | SEA | 1 | CYC | 0 | Bard,D | Almonte,Y | Kintzler | Lowe,B |
| 5/29/2021 | | | NUT | 1 | SMC | 9 | Gonzales | Javier | | d'Arnaud |
| 5/29/2021 | | | PAN | 6 | PLU | 5 | Watson | Peralta,W | Heuer | Munoz |
| 5/29/2021 | | | ATK | 6 | BOM | 3 | Montgomery,J | Urias,J | | Pham |
| 5/29/2021 | | | NHH | 4 | PUR | 3 | Barria | Webb,L | Quantrill | Reyes,V |
| 5/30/2021 | | | GOT | 8 | BEA | 7 | Garrett,A | Thompson | Green | Nunez,R |
| 5/30/2021 | | | SEA | 10 | CYC | 1 | Hill,R | Gonzalez,G | Baragar | Lowe,B |
| 5/30/2021 | | | NUT | 12 | SMC | 8 | Crichton | Ferguson | | Fletcher,D |
| 5/30/2021 | | | PAN | 4 | PLU | 6 | Rogers,Ty | Trivino | | Dickerson,C |
| 5/30/2021 | | | ATK | 5 | BOM | 0 | Yarbrough | Houser | | Votto |
| 5/30/2021 | | 13 | NHH | 3 | PUR | 4 | Finnegan | Allen,L | | Davis,JD |
| 5/31/2021 | | | GOT | 4 | BEA | 3 | Gray,S | Sanchez,An | Hernandez,J | Nola,Au |
| 5/31/2021 | | | SEA | 10 | CYC | 5 | Bassitt | Anderson,Bre | | Lowe,B |
| 5/31/2021 | | | NUT | 10 | SMC | 4 | Manaea | Walker,T | Neris | Sano |
| 5/31/2021 | | 10 | PAN | 7 | PLU | 6 | Heuer | Rogers,Ty | | Tapia,R |
| 5/31/2021 | | | ATK | 2 | BOM | 9 | deGrom | Fried | | Story |
| 5/31/2021 | | | NHH | 0 | PUR | 2 | Freeland | Minor | Diekman | La Stella |
| 6/1/2021 | | | NUT | 1 | GOT | 4 | Margevicius | Senzatela | | Smith,Do |
| 6/1/2021 | | | PUR | 2 | CYC | 5 | Means | Canning | Bass | Panik |
| 6/1/2021 | | | PAN | 4 | SMC | 5 | Greene | Trivino | Melancon | Grossman |
| 6/1/2021 | | | SEA | 2 | PLU | 8 | Sanchez,S | Snell | | Moncada |
| 6/1/2021 | | | ATK | 6 | NHH | 2 | Skubal | Gray,J | Martin,C | Votto |
| 6/1/2021 | | 10 | BEA | 2 | BOM | 3 | Romano,J | Rosenthal | | Goldschmidt |
| 6/2/2021 | | | NUT | 4 | GOT | 5 | Baez,P | Yardley | | |
| 6/2/2021 | | 12 | PUR | 6 | CYC | 5 | Ramirez,Y | Bass | Jeffress | Gamel |
| 6/2/2021 | | | PAN | 10 | SMC | 4 | Trivino | Luzardo | | White,Ev |
| 6/2/2021 | | | SEA | 2 | PLU | 9 | Davies | Carrasco | | Adell |
| 6/2/2021 | | | ATK | 6 | NHH | 13 | Pineda | Verlander | | Urshela |
| 6/2/2021 | | | BEA | 1 | BOM | 2 | Castillo,D | Rosenthal | | LeMahieu |
| 6/3/2021 | | | NUT | 12 | GOT | 6 | Fedde | Tanaka | | Calhoun,K |
| 6/3/2021 | | 11 | PUR | 2 | CYC | 0 | Jeffress | Norris | | Renfroe |
| 6/3/2021 | | | PAN | 5 | SMC | 4 | Lopez,J | Gonzales | Heuer | Tapia,R |
| 6/3/2021 | | | SEA | 19 | PLU | 8 | Hill,T | McKenzie | | Ruiz,R |
| 6/3/2021 | | | ATK | 0 | NHH | 3 | Tepera | Montgomery,J | Quantrill | Conforto |
| 6/3/2021 | | | BEA | 3 | BOM | 2 | Porcello | Urias,J | Fry,P | Cano |
| 6/4/2021 | | | SEA | 2 | GOT | 3 | Baez,P | Bard,D | | Grisham |
| 6/4/2021 | | | PAN | 6 | CYC | 7 | Strahm | Patino | Bass | Bradley,J |
| 6/4/2021 | | | SMC | 2 | BEA | 3 | Weber | Berrios | Rosenthal | Harper,B |
| 6/4/2021 | | | ATK | 1 | PLU | 2 | Zuber | Yarbrough | Rogers,Ty | |
| 6/4/2021 | | | PUR | 6 | BOM | 8 | Romano,J | Finnegan | Crochet | Brantley |
| 6/4/2021 | | | NUT | 3 | NHH | 4 | Quantrill | Yardley | | Guzman,R |
| 6/5/2021 | | | SEA | 2 | GOT | 3 | Alzolay | Bassitt | Green | Kepler |
| 6/5/2021 | | | PAN | 0 | CYC | 5 | Anderson,Bre | Civale | | |
| 6/5/2021 | | | SMC | 8 | BEA | 9 | Lakins | Melancon | | Judge |
| 6/5/2021 | | | ATK | 1 | PLU | 4 | Glasnow | Fried | Rogers,Ty | Marte,K |
| 6/5/2021 | | | PUR | 7 | BOM | 4 | Freeland | deGrom | Jeffress | Crawford,B |
| 6/5/2021 | | | NUT | 7 | NHH | 6 | Clarke | Tepera | Bradley,A | Gallo |
| 6/6/2021 | | 11 | SEA | 3 | GOT | 4 | Baez,P | Baragar | | Caratini |
| 6/6/2021 | | | PAN | 2 | CYC | 1 | Duffy | Means | Heuer | Owings |
| 6/6/2021 | | | SMC | 5 | BEA | 2 | Pearson | Weber | Melancon | Hampson |
| 6/6/2021 | | | ATK | 7 | PLU | 3 | Skubal | Sanchez,S | | Franco |
| 6/6/2021 | | | PUR | 4 | BOM | 7 | Hendricks | Canning | Crochet | Winker |
| 6/6/2021 | | | NUT | 10 | NHH | 2 | Senzatela | Gray,J | | Calhoun,K |
| 6/7/2021 | | | ATK | 1 | GOT | 8 | Gray,S | Verlander | | Smith,Do |
| 6/7/2021 | | | BEA | 11 | CYC | 4 | Bundy | Alexander,T | | Harper,B |
| 6/7/2021 | | | SMC | 3 | PUR | 1 | Luzardo | Ray | Melancon | Abreu,J |
| 6/7/2021 | | | PAN | 2 | BOM | 3 | Wheeler | Dunn | Romano,J | Marte,S |
| 6/7/2021 | | 11 | NUT | 5 | PLU | 2 | Bradley,A | Gibson | | Hilliard |
| 6/7/2021 | | | SEA | 13 | NHH | 4 | Carrasco | Pineda | | Encarnacion |
| 6/8/2021 | | | ATK | 0 | GOT | 4 | Kershaw | Montgomery,J | | Gregorius |
| 6/8/2021 | | | BEA | 11 | CYC | 8 | Jansen,K | Almonte,Y | Rosenthal | Cano |
| 6/8/2021 | | | SMC | 4 | PUR | 5 | Webb,L | Gonzales | Jeffress | Grichuk |
| 6/8/2021 | | | PAN | 5 | BOM | 12 | Urias,J | Musgrove | | Goldschmidt |
| 6/8/2021 | | | NUT | 5 | PLU | 2 | Fedde | McKenzie | Neris | Gallo |
| 6/8/2021 | | | SEA | 2 | NHH | 9 | Gomber | Mahle | | Kipnis |
| 6/9/2021 | | | ATK | 4 | GOT | 3 | Karinchak | Johnson,P | Martin,C | McCann |
| 6/9/2021 | | | BEA | 2 | CYC | 3 | Mills | Velasquez | Bass | Cabrera,M |
| 6/9/2021 | | | SMC | 2 | PUR | 5 | Hudson,Dak | Berrios | Jeffress | Davis,JD |
| 6/9/2021 | | | PAN | 10 | BOM | 5 | Lopez,J | Houser | | McNeil |
| 6/9/2021 | | | NUT | 1 | PLU | 14 | Maeda | Mazza | | Varsho |
| 6/9/2021 | | | SEA | 4 | NHH | 5 | Brault | Hill,R | Quantrill | Bote |
| 6/11/2021 | | | GOT | 4 | NUT | 3 | Tanaka | Manaea | Green | Arenado |
| 6/11/2021 | | | CYC | 3 | PUR | 4 | Diekman | Almonte,Y | | Crawford,B |
| 6/11/2021 | | | SMC | 6 | PAN | 5 | Greene | Sherriff | Melancon | Quinn |
| 6/11/2021 | | | PLU | 3 | SEA | 2 | Scott | Kintzler | Rogers,Ty | Odor |
| 6/11/2021 | | 10 | NHH | 4 | ATK | 3 | Tepera | Lorenzen | Quantrill | Bote |
| 6/11/2021 | | | BOM | 7 | BEA | 4 | deGrom | Sanchez,An | | Schoop |
| 6/12/2021 | | | GOT | 2 | NUT | 5 | Senzatela | Margevicius | Bradley,A | Longoria |
| 6/12/2021 | | 12 | CYC | 5 | PUR | 4 | Bass | Ramirez,Y | Garcia,Ja | Gyorko |
| 6/12/2021 | | | SMC | 6 | PAN | 4 | Matzek | Civale | Melancon | Abreu,J |
| 6/12/2021 | | | PLU | 5 | SEA | 3 | Sanchez,S | Snell | Rogers,Ty | Odor |
| 6/12/2021 | | | NHH | 3 | ATK | 6 | Skubal | Gray,J | Martin,C | McCann |
| 6/12/2021 | | | BOM | 2 | BEA | 9 | Paddack | Hendricks | | Andrus |
| 6/13/2021 | | | GOT | 2 | NUT | 0 | Lester | Perez,Ma | | Caratini |
| 6/13/2021 | | | CYC | 7 | PUR | 2 | Alexander,T | Ray | | Cabrera,M |
| 6/13/2021 | | | SMC | 2 | PAN | 7 | Duffy | Luzardo | | Kiner-Falefa |
| 6/13/2021 | | | PLU | 5 | SEA | 4 | Davies | Carrasco | Peralta,W | Soler |
| 6/13/2021 | | | NHH | 1 | ATK | 3 | Tomlin | Pineda | Martin,C | Markakis |
| 6/13/2021 | | | BOM | 0 | BEA | 3 | Bundy | Wheeler | Rosenthal | Hiura |
| 6/14/2021 | | | GOT | 9 | NUT | 1 | Gray,S | Fedde | | Nola,Au |
| 6/14/2021 | | | CYC | 9 | PUR | 10 | Finnegan | Garcia,B | Jeffress | Gurriel,L |
| 6/14/2021 | | | SMC | 1 | PAN | 7 | Dunn | Gonzales | | McNeil |
| 6/14/2021 | | | PLU | 0 | SEA | 1 | Mahle | McKenzie | Fleming | Braun |
| 6/14/2021 | | | NHH | 4 | ATK | 5 | McGee | Quantrill | Martin,C | Barnhart |
| 6/14/2021 | | | BOM | 2 | BEA | 8 | Porcello | Urias,J | | McCutchen |
| 6/15/2021 | | | JER | 0 | CYC | 4 | Mills | Junis | | Bradley,J |
| 6/15/2021 | | | LAH | 2 | ATK | 9 | Yarbrough | Castillo,L | | Franco |
| 6/15/2021 | | | HOU | 10 | BEA | 7 | Lamet | Velasquez | | Springer |
| 6/15/2021 | | | SCA | 3 | PAN | 15 | Musgrove | Wright | | McNeil |
| 6/15/2021 | | | CCC | 0 | BOM | 3 | Houser | Valdez,F | Hader | Winker |
| 6/15/2021 | | | ISO | 5 | SMC | 6 | Matzek | Andriese | Melancon | Abreu,J |
| 6/15/2021 | | 11 | LTR | 2 | NUT | 3 | Neris | Wisler | | |
| 6/15/2021 | | | PHS | 5 | PUR | 3 | Giolito | Finnegan | Anderson,N | Solano |
| 6/15/2021 | | | WHC | 5 | SEA | 9 | Fleming | Soto,G | | Moore |
| 6/15/2021 | | 12 | LVB | 3 | GOT | 4 | Hernandez,J | Castellani | | Arenado |
| 6/15/2021 | | 10 | JOT | 7 | PLU | 3 | Cabrera,G | Zuber | | Villar |
| 6/15/2021 | | | COL | 0 | NHH | 8 | Brault | Scherzer | | Conforto |
| 6/16/2021 | | | JER | 3 | CYC | 10 | Anderson,Bre | Singer | | |
| 6/16/2021 | | | LAH | 4 | ATK | 5 | Williams,D | Keuchel | Martin,C | Franco |
| 6/16/2021 | | | HOU | 17 | BEA | 2 | Bauer | Sanchez,An | | Tatis |
| 6/16/2021 | | | SCA | 8 | PAN | 9 | Turley | Rogers,Ta | Trivino | Bart |
| 6/16/2021 | | | CCC | 0 | BOM | 8 | deGrom | Lynn | | Marte,S |
| 6/16/2021 | | | ISO | 0 | SMC | 7 | Lugo,S | Eovaldi | | |
| 6/16/2021 | | | LTR | 2 | NUT | 6 | Manaea | Lopez,P | | Calhoun,K |
| 6/16/2021 | | | PHS | 4 | PUR | 7 | Freeland | Cueto | Diekman | Hernandez,T |
| 6/16/2021 | | | WHC | 5 | SEA | 0 | Keller,B | Bassitt | | Stewart,C |
| 6/16/2021 | | | LVB | 0 | GOT | 5 | Alzolay | Cease | | Aguilar |
| 6/16/2021 | | | JOT | 3 | PLU | 2 | Cabrera,G | Gibson | Castro,M | Stanton |
| 6/16/2021 | | | COL | 2 | NHH | 3 | Minor | Greinke | Quantrill | Reyes,V |
| 6/17/2021 | | | JER | 0 | CYC | 4 | Means | Roark | | Gonzalez,E |
| 6/17/2021 | | | LAH | 7 | ATK | 2 | May,D | Skubal | | Dubon |
| 6/17/2021 | | | HOU | 7 | BEA | 3 | Burnes | Paddack | | Machado |
| 6/17/2021 | | | SCA | 6 | PAN | 2 | Turnbull | Matz | | Yelich |
| 6/17/2021 | | | CCC | 5 | BOM | 6 | Crochet | Hand | | Stallings |
| 6/17/2021 | | | ISO | 2 | SMC | 4 | Pearson | Kim | Melancon | Anderson,Bri |
| 6/17/2021 | | 10 | LTR | 8 | NUT | 10 | Crichton | Zimmer,K | | Calhoun,K |
| 6/17/2021 | | | PHS | 3 | PUR | 6 | Canning | Cody | | Hernandez,T |
| 6/17/2021 | | | WHC | 4 | SEA | 6 | Bard,D | Plesac | Kintzler | Goodwin |
| 6/17/2021 | | | LVB | 7 | GOT | 11 | Smith,C | Rogers,Tr | | Laureano |
| 6/17/2021 | | | JOT | 12 | PLU | 15 | Hunter | Alcala | Rodon | Moncada |
| 6/17/2021 | | | COL | 4 | NHH | 0 | Lindblom | Gray,J | | Escobar |
| 6/18/2021 | | | CYC | 6 | JER | 4 | Almonte,Y | Montas | Bass | Albies |
| 6/18/2021 | | | ATK | 4 | LAH | 5 | Valdez,C | Martin,C | | Nimmo |
| 6/18/2021 | | | BEA | 4 | HOU | 6 | Armstrong | Rosenthal | | Springer |
| 6/18/2021 | | | PAN | 3 | SCA | 2 | Trivino | Montero | Heuer | Diaz,El |
| 6/18/2021 | | | BOM | 5 | CCC | 7 | Diaz,Ed | Tate | Hand | Rizzo |
| 6/18/2021 | | | SMC | 5 | ISO | 7 | Raley | Lugo,S | Antone | Betts |
| 6/18/2021 | | | NUT | 8 | LTR | 6 | Perez,Ma | Eflin | Bradley,A | Calhoun,K |
| 6/18/2021 | | | PUR | 7 | PHS | 8 | Shoemaker | Brasier | Anderson,N | Solano |
| 6/18/2021 | | | SEA | 5 | WHC | 0 | Carrasco | Sheffield | | Goodwin |
| 6/18/2021 | | | GOT | 4 | LVB | 3 | Kuhl | Stripling | Green | Arenado |
| 6/18/2021 | | | PLU | 7 | JOT | 2 | Davies | Flaherty | | Myers |
| 6/18/2021 | | | NHH | 9 | COL | 4 | Pineda | Williams,Tr | | Reyes,V |
| 6/19/2021 | | | CYC | 4 | JER | 1 | Heaney | Weaver | Bass | Albies |
| 6/19/2021 | | | ATK | 2 | LAH | 4 | Woodruff | Montgomery,J | | Merrifield |
| 6/19/2021 | | | BEA | 1 | HOU | 3 | Gallen | Porcello | Foster | Walker,C |
| 6/19/2021 | | | PAN | 10 | SCA | 6 | Duffy | Wright | Heuer | McNeil |
| 6/19/2021 | | | BOM | 4 | CCC | 5 | Nola,Aa | Urias,J | Hand | Cruz,N |
| 6/19/2021 | | | SMC | 2 | ISO | 4 | Menez | Gonzales | Brogdon | Seager,C |
| 6/19/2021 | | | NUT | 6 | LTR | 12 | Duffey | Clarke | | Polanco,J |
| 6/19/2021 | | | PUR | 3 | PHS | 9 | Lopez,R | Webb,L | | Devers |
| 6/19/2021 | | | SEA | 9 | WHC | 1 | Mahle | Oviedo | | Moore |
| 6/19/2021 | | | GOT | 8 | LVB | 2 | Lester | Teheran | | Smith,Do |
| 6/19/2021 | | | PLU | 3 | JOT | 0 | McKenzie | Bumgarner | | Jeffers |
| 6/19/2021 | | | NHH | 14 | COL | 2 | Gomber | Lyles | | Urshela |
| 6/20/2021 | | | CYC | 4 | JER | 3 | Mills | Junis | Garcia,Ja | Bradley,J |
| 6/20/2021 | | | ATK | 0 | LAH | 7 | Castillo,L | Yarbrough | | Merrifield |
| 6/20/2021 | | | BEA | 1 | HOU | 13 | Lamet | Velasquez | | Walker,C |
| 6/20/2021 | | | PAN | 13 | SCA | 1 | Dunn | Wacha | Patino | Harrison,J |
| 6/20/2021 | | | BOM | 4 | CCC | 9 | Valdez,F | Houser | | Rizzo |
| 6/20/2021 | | | SMC | 5 | ISO | 2 | Berrios | Sandoval,Pat | Melancon | Quinn |
| 6/20/2021 | | | NUT | 1 | LTR | 10 | Peterson,D | Mazza | | Soto,J |
| 6/20/2021 | | 11 | PUR | 4 | PHS | 3 | Jeffress | Winkler | Diekman | Belt |
| 6/20/2021 | | | SEA | 4 | WHC | 1 | Hill,R | Urena | Kintzler | Braun |
| 6/20/2021 | | | GOT | 10 | LVB | 2 | Gray,S | Castellani | | Edman |
| 6/20/2021 | | | PLU | 7 | JOT | 0 | Maeda | Toussaint | Gibson | Odor |
| 6/20/2021 | | | NHH | 8 | COL | 2 | Brault | Scherzer | | Wendle |
| 6/21/2021 | | | SEA | 1 | GOT | 9 | Margevicius | Bassitt | | Edman |
| 6/21/2021 | | | PAN | 1 | CYC | 4 | Anderson,Bre | Musgrove | Bass | Cabrera,M |
| 6/21/2021 | | | SMC | 9 | BEA | 4 | Lugo,S | Sanchez,An | Melancon | d'Arnaud |
| 6/21/2021 | | | ATK | 0 | PLU | 1 | Glasnow | Fried | Rogers,Ty | Torres |
| 6/21/2021 | | 10 | PUR | 6 | BOM | 5 | Jeffress | Hader | | Gamel |
| 6/21/2021 | | | NUT | 6 | NHH | 1 | Manaea | Minor | | Murphy,JR |
| 6/22/2021 | | | SEA | 4 | GOT | 6 | Smith,C | Snell | Green | Laureano |
| 6/22/2021 | | 10 | PAN | 3 | CYC | 2 | Heuer | Bass | | Owings |
| 6/22/2021 | | | SMC | 6 | BEA | 8 | Weber | Pearson | Rosenthal | |
| 6/22/2021 | | | ATK | 6 | PLU | 3 | Skubal | Sanchez,S | | Franco |
| 6/22/2021 | | | PUR | 2 | BOM | 8 | Hendricks | Canning | | |
| 6/22/2021 | | | NUT | 4 | NHH | 6 | Kolarek | Yardley | Quantrill | Urshela |
| 6/23/2021 | | | SEA | 6 | GOT | 4 | Carrasco | Kershaw | Kintzler | Goodwin |
| 6/23/2021 | | | PAN | 5 | CYC | 15 | Alexander,T | Matz | | Locastro |
| 6/23/2021 | | | SMC | 9 | BEA | 4 | Greene | Bundy | | Abreu,J |
| 6/23/2021 | | | ATK | 5 | PLU | 7 | Davies | Lorenzen | Rogers,Ty | Odor |
| 6/23/2021 | | | PUR | 2 | BOM | 5 | Wheeler | Staumont | Romano,J | Winker |
| 6/23/2021 | | | NUT | 1 | NHH | 6 | Farmer,B | Perez,Ma | Tepera | Conforto |
| 6/25/2021 | | | GOT | 2 | SEA | 3 | Mahle | Kershaw | Kintzler | Farmer,K |
| 6/25/2021 | | | CYC | 4 | PAN | 3 | Almonte,Y | Civale | Bass | Gyorko |
| 6/25/2021 | | | BEA | 1 | SMC | 10 | Gonzales | Porcello | | Riley |
| 6/25/2021 | | | PLU | 2 | ATK | 3 | Montgomery,J | Scott | Martin,C | Yastrzemski |
| 6/25/2021 | | | BOM | 4 | PUR | 5 | Brasier | Castillo,D | Jeffress | Crawford,B |
| 6/25/2021 | | | NHH | 8 | NUT | 2 | Graveman | Fedde | Farmer,B | |
| 6/26/2021 | | | GOT | 2 | SEA | 4 | Hill,R | Tanaka | Bard,D | Encarnacion |
| 6/26/2021 | | | CYC | 7 | PAN | 0 | Mills | Duffy | | Ahmed |
| 6/26/2021 | | | BEA | 9 | SMC | 4 | Velasquez | Berrios | | Chapman,M |
| 6/26/2021 | | | PLU | 8 | ATK | 4 | Maeda | Yarbrough | | Myers |
| 6/26/2021 | | | BOM | 6 | PUR | 4 | Bedrosian | Diekman | Hader | Brosseau |
| 6/26/2021 | | | NHH | 5 | NUT | 7 | Neris | Tepera | Bradley,A | |
| 6/27/2021 | | | GOT | 5 | SEA | 9 | Baragar | Margevicius | Fleming | Ruiz,R |
| 6/27/2021 | | | CYC | 1 | PAN | 3 | Dunn | Anderson,Bre | Heuer | Harrison,J |
| 6/27/2021 | | | BEA | 12 | SMC | 8 | Sanchez,An | Walker,T | Rosenthal | Smith,WD |
| 6/27/2021 | | | PLU | 6 | ATK | 3 | Glasnow | Fried | Rogers,Ty | Marte,K |
| 6/27/2021 | | 10 | BOM | 5 | PUR | 6 | Jeffress | Colome | | Belt |
| 6/27/2021 | | | NHH | 9 | NUT | 8 | Tepera | Bradley,A | Quantrill | Guzman,R |
| 6/28/2021 | | | GOT | 7 | ATK | 1 | Kuhl | Skubal | | Aguilar |
| 6/28/2021 | | | CYC | 3 | BEA | 7 | Weber | Means | Pomeranz | Judge |
| 6/28/2021 | | | PUR | 4 | SMC | 8 | Ramirez,No | Canning | | Abreu,J |
| 6/28/2021 | | | BOM | 11 | PAN | 2 | Hendricks | Musgrove | | Brantley |
| 6/28/2021 | | | PLU | 3 | NUT | 2 | Sanchez,S | Senzatela | Rogers,Ty | Soler |
| 6/28/2021 | | | NHH | 2 | SEA | 6 | Snell | Gray,J | | Braun |
| 6/29/2021 | | | GOT | 3 | ATK | 2 | Baez,P | Martin,C | Green | Nola,Au |
| 6/29/2021 | | | CYC | 5 | BEA | 7 | Jackson,L | Alexander,T | Rosenthal | Flores,W |
| 6/29/2021 | | | PUR | 5 | SMC | 7 | Matzek | Ray | Melancon | Plawecki |
| 6/29/2021 | | | BOM | 6 | PAN | 1 | Wheeler | Lopez,J | | Goldschmidt |
| 6/29/2021 | | | PLU | 4 | NUT | 5 | Neris | Davies | Bradley,A | Fletcher,D |
| 6/29/2021 | | | NHH | 2 | SEA | 5 | Fleming | Pineda | | Moore |
| 6/30/2021 | | | GOT | 3 | ATK | 6 | Williams,D | Smith,WM | Treinen | Solak |
| 6/30/2021 | | | CYC | 1 | BEA | 6 | Jansen,K | Heaney | | Judge |
| 6/30/2021 | | | PUR | 4 | SMC | 9 | Gonzales | Webb,L | | Peraza |
| 6/30/2021 | | | BOM | 7 | PAN | 4 | Urias,J | Matz | Colome | Brosseau |
| 6/30/2021 | | 11 | PLU | 8 | NUT | 9 | Clarke | Rogers,Ty | | Hilliard |
| 6/30/2021 | | | NHH | 4 | SEA | 3 | Gomber | Mahle | Quantrill | Stassi |
| 7/1/2021 | | 15 | BOM | 5 | GOT | 3 | Hader | Barlow | Wendelken | Brosseau |
| 7/1/2021 | | 10 | CYC | 5 | SEA | 6 | Soria | Bass | | Jansen,D |
| 7/1/2021 | | | SMC | 3 | NUT | 10 | Crichton | Berrios | Neris | Calhoun,K |
| 7/1/2021 | | | PLU | 3 | PAN | 4 | Hudson,Dan | Rogers,Ty | | Urias,R |
| 7/1/2021 | | | BEA | 5 | ATK | 8 | Soroka | Sanchez,An | McGee | Yastrzemski |
| 7/1/2021 | | | NHH | 4 | PUR | 5 | Diekman | Newberry | Jeffress | Grichuk |
| 7/2/2021 | | 10 | BOM | 3 | GOT | 4 | Familia | Wendelken | | Edman |
| 7/2/2021 | | | CYC | 6 | SEA | 1 | Anderson,Bre | Bassitt | | Castellanos,N |
| 7/2/2021 | | | SMC | 2 | NUT | 6 | Manaea | Walker,T | | Murphy,D |
| 7/2/2021 | | | PLU | 2 | PAN | 7 | Duffy | Gibson | McGowin | Robert |
| 7/2/2021 | | | BEA | 6 | ATK | 9 | Bailey,H | Paddack | | Franco |
| 7/2/2021 | | | NHH | 7 | PUR | 2 | Newberry | Freeland | | Urshela |
| 7/3/2021 | | | BOM | 4 | GOT | 12 | Lester | Castillo,D | | Nunez,R |
| 7/3/2021 | | 12 | CYC | 9 | SEA | 8 | Pressly | Hill,T | | Ahmed |
| 7/3/2021 | | | SMC | 3 | NUT | 11 | Senzatela | Pearson | Fairbanks | Calhoun,K |
| 7/3/2021 | | | PLU | 4 | PAN | 3 | Sanchez,S | Dunn | Rogers,Ty | Jeffers |
| 7/3/2021 | | | BEA | 12 | ATK | 2 | Bundy | Fried | | Flores,W |
| 7/3/2021 | | | NHH | 1 | PUR | 4 | Canning | Gray,J | Staumont | Belt |
| 7/4/2021 | | | GOT | 12 | SMC | 7 | Green | Luzardo | | Gregorius |
| 7/4/2021 | | | PLU | 5 | CYC | 8 | Happ,JA | Davies | | |
| 7/4/2021 | | | SEA | 2 | PAN | 1 | Hill,R | Musgrove | Kintzler | Braun |
| 7/4/2021 | | | PUR | 1 | ATK | 8 | Yarbrough | Ray | | Pham |
| 7/4/2021 | | | NHH | 5 | BOM | 4 | Pineda | Wheeler | Quantrill | Conforto |
| 7/4/2021 | | | BEA | 2 | NUT | 8 | Perez,Ma | Porcello | | Sano |
| 7/5/2021 | | | GOT | 5 | SMC | 2 | Kershaw | Gonzales | Green | Aguilar |
| 7/5/2021 | | | PLU | 0 | CYC | 1 | Heaney | McKenzie | Pressly | Gurriel,Y |
| 7/5/2021 | | | SEA | 5 | PAN | 2 | Bassitt | Castano | | Alberto |
| 7/5/2021 | | | PUR | 4 | ATK | 5 | Soroka | Webb,L | Williams,D | Bruce |
| 7/5/2021 | | | NHH | 1 | BOM | 7 | Urias,J | Graveman | | Schoop |
| 7/5/2021 | | | BEA | 6 | NUT | 5 | Fry,P | Yardley | Jansen,K | Chapman,M |
| 7/6/2021 | | | GOT | 1 | SMC | 4 | Berrios | Kuhl | Melancon | |
| 7/6/2021 | | | PLU | 1 | CYC | 6 | Mills | DeSclafani | | Cabrera,M |
| 7/6/2021 | | | SEA | 5 | PAN | 1 | Snell | Civale | | Arcia |
| 7/6/2021 | | | PUR | 7 | ATK | 2 | Eshelman | Bailey,H | | Crawford,B |
| 7/6/2021 | | | NHH | 3 | BOM | 4 | Hader | Newberry | Rodriguez,R | Marte,S |
| 7/6/2021 | | | BEA | 2 | NUT | 1 | Sanchez,An | Mazza | Jansen,K | |
| 7/7/2021 | | | BEA | 3 | GOT | 4 | Alzolay | Paddack | Green | Gregorius |
| 7/7/2021 | | | NHH | 9 | CYC | 8 | Minor | Anderson,Bre | Quantrill | Conforto |
| 7/7/2021 | | | PLU | 6 | SMC | 11 | Walker,T | Gibson | | Grossman |
| 7/7/2021 | | | NUT | 4 | PAN | 2 | Manaea | Duffy | Yardley | Fletcher,D |
| 7/7/2021 | | | PUR | 6 | SEA | 1 | Freeland | Carrasco | | Belt |
| 7/7/2021 | | | BOM | 11 | ATK | 2 | deGrom | Montgomery,J | Suter | Brosseau |
| 7/8/2021 | | 11 | BEA | 8 | GOT | 7 | Jansen,K | Barlow | | Judge |
| 7/8/2021 | | | NHH | 2 | CYC | 4 | Means | Gray,J | Pressly | Gurriel,Y |
| 7/8/2021 | | | PLU | 5 | SMC | 8 | Anderson,I | Sanchez,S | Melancon | Hampson |
| 7/8/2021 | | | NUT | 5 | PAN | 0 | Senzatela | Dunn | | Gallo |
| 7/8/2021 | | | PUR | 4 | SEA | 6 | Mahle | Canning | Kintzler | Encarnacion |
| 7/8/2021 | | | BOM | 1 | ATK | 6 | Fried | Hendricks | | Yastrzemski |
| 7/9/2021 | | | BEA | 1 | GOT | 4 | Tanaka | Porcello | Hernandez,J | Edman |
| 7/9/2021 | | | NHH | 3 | CYC | 0 | Pineda | Happ,JA | Vincent | Reyes,V |
| 7/9/2021 | | | PLU | 6 | SMC | 14 | Lugo,S | Davies | | Biggio |
| 7/9/2021 | | | NUT | 1 | PAN | 5 | Musgrove | Perez,Ma | | McNeil |
| 7/9/2021 | | | PUR | 3 | SEA | 6 | Hill,R | Ray | Kintzler | Hosmer |
| 7/9/2021 | | | BOM | 3 | ATK | 6 | Soroka | Wheeler | McGee | Franco |
| 7/14/2021 | | | NUT | 2 | GOT | 10 | Gray,S | Fedde | | Nola,Au |
| 7/14/2021 | | | PUR | 4 | CYC | 5 | Wilson,J | Finnegan | Pressly | |
| 7/14/2021 | | 14 | PAN | 3 | SMC | 1 | Wick | Lugo,S | | Urias,R |
| 7/14/2021 | | | SEA | 4 | PLU | 2 | Bassitt | McKenzie | Kintzler | Arcia |
| 7/14/2021 | | | ATK | 5 | NHH | 1 | Yarbrough | Gray,J | Karinchak | McCann |
| 7/14/2021 | | | BEA | 1 | BOM | 8 | Urias,J | Velasquez | | Goldschmidt |
| 7/15/2021 | | | NUT | 5 | GOT | 2 | Mazza | Barlow | Yardley | Fletcher,D |
| 7/15/2021 | | | PUR | 3 | CYC | 0 | Eshelman | Mills | Jeffress | Hernandez,T |
| 7/15/2021 | | | PAN | 3 | SMC | 0 | Civale | Gonzales | Trivino | Beaty |
| 7/15/2021 | | | SEA | 11 | PLU | 10 | Kintzler | Hughes | | Arcia |
| 7/15/2021 | | | ATK | 8 | NHH | 11 | Graveman | Soroka | Quantrill | Conforto |
| 7/15/2021 | | | BEA | 4 | BOM | 5 | Suter | Weber | Hader | Goldschmidt |
| 7/16/2021 | | | NUT | 0 | GOT | 5 | Smith,C | Manaea | | Edman |
| 7/16/2021 | | | PUR | 10 | CYC | 2 | Freeland | Anderson,Bre | | Crawford,B |
| 7/16/2021 | | | PAN | 0 | SMC | 2 | Berrios | Duffy | Melancon | Riley |
| 7/16/2021 | | | SEA | 3 | PLU | 4 | Glasnow | Carrasco | Rogers,Ty | |
| 7/16/2021 | | 10 | ATK | 6 | NHH | 7 | Quantrill | McGee | | Kipnis |
| 7/16/2021 | | | BEA | 6 | BOM | 9 | deGrom | Paddack | Castillo,D | Goldschmidt |
| 7/17/2021 | | | NUT | 2 | GOT | 4 | Lester | Senzatela | Green | Nunez,R |
| 7/17/2021 | | | PUR | 6 | CYC | 5 | Canning | Bass | Jeffress | Grichuk |
| 7/17/2021 | | 11 | PAN | 1 | SMC | 2 | Greene | Sherriff | | Abreu,J |
| 7/17/2021 | | | SEA | 0 | PLU | 2 | Sanchez,S | Soria | Hughes | Soler |
| 7/17/2021 | | | ATK | 7 | NHH | 8 | Gomber | Kittredge | | Urshela |
| 7/17/2021 | | | BEA | 7 | BOM | 14 | Hill,C | Bundy | | Brantley |
| 7/18/2021 | | | GOT | 2 | BOM | 9 | Wheeler | Tanaka | | Dickerson,A |
| 7/18/2021 | | | SEA | 5 | CYC | 3 | Hill,R | Happ,JA | Kintzler | Alberto |
| 7/18/2021 | | | NUT | 4 | SMC | 0 | Perez,Ma | Anderson,I | | Calhoun,K |
| 7/18/2021 | | | PAN | 2 | PLU | 7 | Davies | Musgrove | | Jeffers |
| 7/18/2021 | | 10 | ATK | 9 | BEA | 10 | Pomeranz | Kittredge | | Flores,W |
| 7/18/2021 | | | PUR | 9 | NHH | 8 | Staumont | Smith,JA | Jeffress | Belt |
| 7/19/2021 | | | GOT | 3 | BOM | 4 | Castillo,D | Gray,S | Hader | Winker |
| 7/19/2021 | | | SEA | 7 | CYC | 1 | Bassitt | Heaney | | Goodwin |
| 7/19/2021 | | | NUT | 3 | SMC | 6 | Lugo,S | Fedde | | Anderson,Bri |
| 7/19/2021 | | | PAN | 3 | PLU | 2 | Trivino | Beeks | Heuer | Robert |
| 7/19/2021 | | | ATK | 9 | BEA | 14 | Weber | Soroka | | Smith,WD |
| 7/19/2021 | | | PUR | 5 | NHH | 4 | Webb,L | Gray,J | Jeffress | Belt |
| 7/20/2021 | | | GOT | 3 | BOM | 2 | Kershaw | Houser | Green | Grisham |
| 7/20/2021 | | | SEA | 1 | CYC | 8 | Mills | Snell | | Castellanos,N |
| 7/20/2021 | | | NUT | 3 | SMC | 4 | Matzek | Yardley | | Biggio |
| 7/20/2021 | | | PAN | 2 | PLU | 7 | Kelly,M | Civale | | Altuve |
| 7/20/2021 | | | ATK | 5 | BEA | 3 | Yarbrough | Sanchez,An | McGee | Gonzalez,M |
| 7/20/2021 | | | PUR | 11 | NHH | 4 | Brasier | Graveman | | Hernandez,T |
| 7/22/2021 | | | GOT | 10 | NUT | 5 | Kuhl | Manaea | | Arenado |
| 7/22/2021 | | | CYC | 3 | PUR | 1 | Anderson,Bre | Freeland | Bass | Casali |
| 7/22/2021 | | | SMC | 6 | PAN | 0 | Gonzales | Duffy | | Riley |
| 7/22/2021 | | 18 | PLU | 15 | SEA | 11 | Beeks | Fleming | | Adell |
| 7/22/2021 | | | NHH | 6 | ATK | 8 | Bailey,H | Minor | McGee | McCann |
| 7/22/2021 | | | BOM | 14 | BEA | 11 | Colome | Paddack | | Schoop |
| 7/23/2021 | | | GOT | 4 | NUT | 0 | Margevicius | Senzatela | | Nola,Au |
| 7/23/2021 | | | CYC | 4 | PUR | 5 | Finnegan | Bass | | Dozier,H |
| 7/23/2021 | | | SMC | 4 | PAN | 6 | Dunn | Berrios | Heuer | Robert |
| 7/23/2021 | | | PLU | 9 | SEA | 4 | Sanchez,S | Mahle | | Smoak |
| 7/23/2021 | | 11 | NHH | 4 | ATK | 3 | Quantrill | Lorenzen | Smith,JA | Urshela |
| 7/23/2021 | | | BOM | 1 | BEA | 8 | Bundy | Hendricks | | Harper,B |
| 7/24/2021 | | | GOT | 6 | NUT | 9 | Perez,Ma | Tanaka | Crichton | Sano |
| 7/24/2021 | | | CYC | 1 | PUR | 2 | Ray | Happ,JA | Jeffress | Renfroe |
| 7/24/2021 | | | SMC | 2 | PAN | 8 | Musgrove | Walker,T | | Bart |
| 7/24/2021 | | | PLU | 1 | SEA | 4 | Hill,R | Davies | Plutko | Lowe,B |
| 7/24/2021 | | | NHH | 6 | ATK | 4 | Pineda | Montgomery,J | Smith,JA | Bote |
| 7/24/2021 | | | BOM | 6 | BEA | 3 | Wheeler | Fry,P | Colome | Schoop |
| 7/26/2021 | | | SMC | 2 | GOT | 6 | Alzolay | Pearson | | Kepler |
| 7/26/2021 | | | CYC | 3 | PLU | 4 | Hughes | Heaney | | Marte,K |
| 7/26/2021 | | | PAN | 0 | SEA | 4 | Bassitt | Watson | | Hosmer |
| 7/26/2021 | | | ATK | 4 | PUR | 0 | Fried | Webb,L | | McCann |
| 7/26/2021 | | 10 | BOM | 4 | NHH | 5 | Quantrill | Hader | | Guzman,R |
| 7/26/2021 | | | NUT | 4 | BEA | 6 | Velasquez | Fedde | Jansen,K | Wong |
| 7/27/2021 | | | SMC | 10 | GOT | 9 | Luzardo | Smith,C | Melancon | Hampson |
| 7/27/2021 | | | CYC | 9 | PLU | 4 | Mills | DeSclafani | Garcia,Ja | Bemboom |
| 7/27/2021 | | | PAN | 8 | SEA | 0 | Civale | Snell | | Hechavarria |
| 7/27/2021 | | | ATK | 5 | PUR | 6 | Finnegan | Tomlin | Jeffress | Piscotty |
| 7/27/2021 | | | BOM | 12 | NHH | 13 | Smith,JA | Hader | Quantrill | Kipnis |
| 7/27/2021 | | | NUT | 6 | BEA | 3 | Mazza | Medina | Yardley | Sano |
| 7/28/2021 | | | SMC | 9 | GOT | 4 | Gonzales | Lester | | Abreu,J |
| 7/28/2021 | | | CYC | 1 | PLU | 5 | Gonsolin | Anderson,Bre | | Smoak |
| 7/28/2021 | | | PAN | 3 | SEA | 6 | Carrasco | Duffy | | Hosmer |
| 7/28/2021 | | | ATK | 8 | PUR | 11 | Jeffress | McGee | | Hernandez,T |
| 7/28/2021 | | | BOM | 9 | NHH | 5 | deGrom | Minor | | LeMahieu |
| 7/28/2021 | | | NUT | 0 | BEA | 11 | Paddack | Manaea | | Andrus |
| 7/29/2021 | | | GOT | 1 | BEA | 8 | Bundy | Gray,S | | Trout |
| 7/29/2021 | | | CYC | 7 | NHH | 4 | Means | Brault | Bass | Bradley,J |
| 7/29/2021 | | | SMC | 5 | PLU | 6 | Hughes | Berrios | Holder | Soler |
| 7/29/2021 | | 11 | PAN | 7 | NUT | 4 | Heuer | Crichton | | White,Ev |
| 7/29/2021 | | | SEA | 4 | PUR | 3 | Mahle | Canning | Kintzler | Hosmer |
| 7/29/2021 | | | ATK | 0 | BOM | 4 | Hendricks | Yarbrough | | Story |
| 7/30/2021 | | | GOT | 5 | BEA | 4 | Kershaw | Porcello | Green | Grisham |
| 7/30/2021 | | | CYC | 0 | NHH | 3 | Pineda | Happ,JA | Gomber | Urshela |
| 7/30/2021 | | | SMC | 4 | PLU | 5 | Zuber | Greene | | Choo |
| 7/30/2021 | | 10 | PAN | 3 | NUT | 1 | Heuer | Crichton | | Robert |
| 7/30/2021 | | | SEA | 3 | PUR | 0 | Hill,R | Ray | Kintzler | Lowe,B |
| 7/30/2021 | | | ATK | 2 | BOM | 6 | Wheeler | Montgomery,J | | Winker |
| 7/31/2021 | | | GOT | 13 | BEA | 5 | Hernandez,J | Velasquez | | Arenado |
| 7/31/2021 | | | CYC | 9 | NHH | 5 | Heaney | Graveman | Garcia,Ja | Gonzalez,E |
| 7/31/2021 | | | SMC | 9 | PLU | 4 | Ramirez,No | Gibson | Matzek | Biggio |
| 7/31/2021 | | | PAN | 2 | NUT | 6 | Fedde | Castano | | Bohm |
| 7/31/2021 | | | SEA | 4 | PUR | 5 | Scrubb | Bassitt | Staumont | Crawford,B |
| 7/31/2021 | | | ATK | 4 | BOM | 7 | Urias,J | Soroka | | Taylor,T |
| 8/1/2021 | | | GOT | 3 | SMC | 4 | Cishek | Tanaka | Melancon | Dietrich |
| 8/1/2021 | | | PLU | 8 | CYC | 5 | Peralta,W | Mills | Beeks | Altuve |
| 8/1/2021 | | 11 | SEA | 8 | PAN | 6 | Kimbrel | Wick | Stammen | Farmer,K |
| 8/1/2021 | | | ATK | 4 | PUR | 3 | Lorenzen | Richards,T | McGee | Barnhart |
| 8/1/2021 | | | NHH | 3 | BOM | 15 | Rodriguez,R | Gray,J | | Goldschmidt |
| 8/1/2021 | | 11 | NUT | 4 | BEA | 2 | Yardley | Lakins | Misiewicz | Carlson |
| 8/2/2021 | | | GOT | 4 | SMC | 10 | Berrios | Gray,S | | Abreu,J |
| 8/2/2021 | | | PLU | 5 | CYC | 9 | Strahm | Hughes | | Bradley,J |
| 8/2/2021 | | 10 | SEA | 4 | PAN | 2 | Stammen | Fulmer,C | | Arcia |
| 8/2/2021 | | | ATK | 5 | PUR | 6 | Finnegan | Fried | Jeffress | Hernandez,T |
| 8/2/2021 | | | NHH | 1 | BOM | 11 | deGrom | Nova | | Story |
| 8/2/2021 | | | NUT | 2 | BEA | 3 | Thompson | Boxberger | | Smith,WD |
| 8/3/2021 | | | GOT | 1 | SMC | 5 | Detwiler | Lester | | Plawecki |
| 8/3/2021 | | | PLU | 5 | CYC | 3 | Peralta,W | Means | Rogers,Ty | Marte,K |
| 8/3/2021 | | | SEA | 8 | PAN | 4 | Mahle | LeBlanc | | Blackmon |
| 8/3/2021 | | | ATK | 4 | PUR | 3 | Braymer | Canning | McGee | Bruce |
| 8/3/2021 | | | NHH | 1 | BOM | 3 | Hendricks | Brault | | Davis,K |
| 8/3/2021 | | | NUT | 9 | BEA | 10 | Nelson,N | Sadler | | Chapman,M |
| 8/4/2021 | | 15 | GOT | 5 | BOM | 6 | Rodriguez,R | Green | | LeMahieu |
| 8/4/2021 | | | NHH | 3 | CYC | 4 | Happ,JA | Quantrill | | Pina |
| 8/4/2021 | | | PLU | 3 | SMC | 6 | Gonzales | Davies | Melancon | d'Arnaud |
| 8/4/2021 | | | NUT | 4 | PAN | 0 | Perez,Ma | Dunn | | Bohm |
| 8/4/2021 | | | SEA | 6 | PUR | 11 | Ray | Morton | | Hernandez,T |
| 8/4/2021 | | | ATK | 5 | BEA | 6 | Fry,P | McGee | | Molina |
| 8/5/2021 | | | GOT | 10 | BOM | 5 | Kuhl | Urias,J | | Smith,Do |
| 8/5/2021 | | | NHH | 13 | CYC | 5 | Urquidy | Heaney | | Lewis |
| 8/5/2021 | | | PLU | 6 | SMC | 5 | Holder | May,T | Rogers,Ty | |
| 8/5/2021 | | | NUT | 4 | PAN | 9 | Castano | Fedde | | Kiner-Falefa |
| 8/5/2021 | | | SEA | 5 | PUR | 3 | Bassitt | Webb,L | Kintzler | Hosmer |
| 8/5/2021 | | | ATK | 6 | BEA | 4 | Gonzalez,C | Porcello | McGee | McCann |
| 8/6/2021 | | | GOT | 5 | BOM | 4 | Tanaka | Ponce de Leon | Garrett,A | Nola,Au |
| 8/6/2021 | | | NHH | 11 | CYC | 6 | Wojciechowski | Garrett,B | | Hays |
| 8/6/2021 | | | PLU | 1 | SMC | 11 | Detwiler | DeSclafani | | Grossman |
| 8/6/2021 | | | NUT | 4 | PAN | 2 | Borucki | Hudson,Dan | Yardley | Bohm |
| 8/6/2021 | | | SEA | 0 | PUR | 2 | Richards,T | Snell | Jeffress | Gurriel,L |
| 8/6/2021 | | 10 | ATK | 4 | BEA | 3 | Graterol | Jansen,K | Yarbrough | Votto |
| 8/7/2021 | | | GOT | 2 | CYC | 3 | Anderson,Bre | Gray,S | Pressly | Albies |
| 8/7/2021 | | | NHH | 3 | SMC | 15 | Anderson,I | Nova | | d'Arnaud |
| 8/7/2021 | | | ATK | 6 | PAN | 5 | Lorenzen | Civale | McGee | Bruce |
| 8/7/2021 | | | PLU | 1 | BOM | 3 | deGrom | Gonsolin | | Castro,J |
| 8/7/2021 | | | SEA | 6 | BEA | 8 | Sanchez,An | Carrasco | | Smith,WD |
| 8/7/2021 | | | NUT | 4 | PUR | 2 | Manaea | Freeland | Yardley | Gallo |
| 8/8/2021 | | 11 | GOT | 2 | CYC | 3 | Wilson,J | Green | | Casali |
| 8/8/2021 | | | NHH | 6 | SMC | 10 | Gonzales | Brault | | Abreu,J |
| 8/8/2021 | | | ATK | 7 | PAN | 3 | Tomlin | Duffy | Williams,D | |
| 8/8/2021 | | | PLU | 5 | BOM | 4 | Holder | Colome | Rogers,Ty | Jeffers |
| 8/8/2021 | | | SEA | 2 | BEA | 19 | Mize | Mahle | Hatch | Trout |
| 8/8/2021 | | | NUT | 0 | PUR | 2 | Staumont | Senzatela | Jeffress | Belt |
| 8/9/2021 | | | GOT | 4 | CYC | 5 | Norris | Garrett,A | Pressly | Ahmed |
| 8/9/2021 | | | NHH | 7 | SMC | 3 | Minor | Walker,T | | Freeman,M |
| 8/9/2021 | | | ATK | 2 | PAN | 4 | LeBlanc | Gonzalez,C | Wick | Moreland |
| 8/9/2021 | | | PLU | 1 | BOM | 7 | Wheeler | Davies | | Goldschmidt |
| 8/9/2021 | | | SEA | 2 | BEA | 9 | Bundy | Morton | | Harper,B |
| 8/9/2021 | | | NUT | 0 | PUR | 5 | Ramirez,Y | Perez,Ma | Jeffress | Dozier,H |
| 8/10/2021 | | | GOT | 6 | CYC | 5 | Johnson,P | Garcia,B | Green | Engel |
| 8/10/2021 | | | NHH | 3 | SMC | 6 | Loup | Urquidy | Melancon | Anderson,Bri |
| 8/10/2021 | | | ATK | 4 | PAN | 1 | Fried | Dunn | McGee | Franco |
| 8/10/2021 | | | PLU | 0 | BOM | 4 | Urias,J | Gibson | Hader | Goldschmidt |
| 8/10/2021 | | | SEA | 6 | BEA | 0 | Bassitt | Porcello | | Lopes,T |
| 8/10/2021 | | | NUT | 1 | PUR | 2 | Webb,L | Fedde | Finnegan | Hernandez,T |
| 8/12/2021 | | 12 | SMC | 8 | GOT | 6 | May,T | Garrett,A | | Riley |
| 8/12/2021 | | | CYC | 8 | PLU | 3 | Norris | Rodon | Almonte,Y | Castellanos,N |
| 8/12/2021 | | | PAN | 2 | SEA | 1 | Castano | Kimbrel | Trivino | Moreland |
| 8/12/2021 | | | PUR | 5 | ATK | 8 | Montgomery,J | Brasier | McGee | Bruce |
| 8/12/2021 | | | BOM | 14 | NHH | 2 | Ponce de Leon | Gray,J | Hill,C | Story |
| 8/12/2021 | | | BEA | 3 | NUT | 1 | Velasquez | Javier | Jansen,K | Chapman,M |
| 8/13/2021 | | | SMC | 2 | GOT | 3 | Gray,S | Gonzales | Green | Aguilar |
| 8/13/2021 | | | CYC | 4 | PLU | 3 | Strahm | Beeks | Bass | Cabrera,M |
| 8/13/2021 | | 11 | PAN | 6 | SEA | 7 | Stammen | Trivino | | Lowe,B |
| 8/13/2021 | | | PUR | 19 | ATK | 3 | Freeland | Gonzalez,C | | Gurriel,L |
| 8/13/2021 | | | BOM | 13 | NHH | 6 | deGrom | Nova | | Brantley |
| 8/13/2021 | | | BEA | 9 | NUT | 4 | Paddack | Manaea | | Trout |
| 8/14/2021 | | | SMC | 1 | GOT | 2 | Lester | Ramirez,No | Green | Edman |
| 8/14/2021 | | | CYC | 4 | PLU | 3 | Pressly | Gibson | | Gyorko |
| 8/14/2021 | | | PAN | 0 | SEA | 3 | Mahle | Duffy | Hill,T | Hedges |
| 8/14/2021 | | 17 | PUR | 4 | ATK | 3 | Brasier | Braymer | | Garver |
| 8/14/2021 | | | BOM | 9 | NHH | 1 | Hendricks | Brault | | Brosseau |
| 8/14/2021 | | | BEA | 3 | NUT | 2 | Porcello | Senzatela | Jansen,K | Trout |
| 8/15/2021 | | | BOM | 4 | GOT | 2 | Wheeler | Kershaw | Colome | |
| 8/15/2021 | | | CYC | 6 | NHH | 3 | Strahm | Quantrill | Bass | Casali |
| 8/15/2021 | | | SMC | 3 | PLU | 0 | Anderson,I | Davies | Melancon | |
| 8/15/2021 | | | PAN | 4 | NUT | 1 | LeBlanc | Perez,Ma | Trivino | Robert |
| 8/15/2021 | | | PUR | 4 | SEA | 7 | Morton | Ray | Stammen | Wade,T |
| 8/15/2021 | | | BEA | 3 | ATK | 7 | Wilson,B | Mize | | Bruce |
| 8/16/2021 | | | BOM | 6 | GOT | 4 | Urias,J | Margevicius | Hader | Brosseau |
| 8/16/2021 | | | CYC | 7 | NHH | 4 | Heaney | Urquidy | Bass | Cabrera,M |
| 8/16/2021 | | | SMC | 6 | PLU | 7 | Hughes | Melancon | | Inciarte |
| 8/16/2021 | | | PAN | 1 | NUT | 6 | Fedde | Dunn | | Bohm |
| 8/16/2021 | | | PUR | 5 | SEA | 7 | Fleming | Finnegan | | Braun |
| 8/16/2021 | | | BEA | 3 | ATK | 7 | Fried | Bundy | | Yastrzemski |
| 8/17/2021 | | | BOM | 7 | GOT | 1 | Ponce de Leon | Tanaka | | Goldschmidt |
| 8/17/2021 | | | CYC | 8 | NHH | 17 | Gray,J | Garrett,B | | Lewis |
| 8/17/2021 | | | SMC | 5 | PLU | 4 | Walker,T | Gibson | Melancon | Riley |
| 8/17/2021 | | | PAN | 6 | NUT | 2 | Castano | Javier | | Kiner-Falefa |
| 8/17/2021 | | | PUR | 13 | SEA | 4 | Benjamin | Snell | | Dozier,H |
| 8/17/2021 | | | BEA | 5 | ATK | 9 | Gonzalez,C | Velasquez | | Garcia,Le |
| 8/19/2021 | | | JER | 2 | PUR | 4 | Canning | Singer | Jeffress | Hernandez,T |
| 8/19/2021 | | | LAH | 9 | SMC | 1 | Keuchel | Lugo,S | | |
| 8/19/2021 | | | HOU | 9 | PLU | 5 | Bauer | Gonsolin | | Tatis |
| 8/19/2021 | | | SCA | 8 | NHH | 4 | Bubic | Nova | Estevez | Castro,S |
| 8/19/2021 | | 12 | CCC | 9 | BEA | 8 | Hand | Thompson | | Realmuto |
| 8/19/2021 | | | ISO | 9 | PAN | 3 | Maeda | Civale | Antone | Betts |
| 8/19/2021 | | | LTR | 9 | CYC | 5 | Lopez,P | Wilson,J | Zimmer,K | Polanco,J |
| 8/19/2021 | | | PHS | 0 | GOT | 1 | Gray,S | Cahill | Green | Aguilar |
| 8/19/2021 | | | WHC | 3 | BOM | 8 | deGrom | Oviedo | | LeMahieu |
| 8/19/2021 | | | JOT | 9 | SEA | 3 | Bieber | Carrasco | Holland,D | Bell |
| 8/19/2021 | | | COL | 4 | ATK | 8 | McGee | Greinke | | Barnhart |
| 8/19/2021 | | | LVB | 2 | NUT | 5 | Manaea | Cease | | Adrianza |
| 8/20/2021 | | | JER | 5 | PUR | 7 | Finnegan | Godley | Jeffress | Belt |
| 8/20/2021 | | | LAH | 4 | SMC | 3 | Perez,O | Ferguson | Hendriks | Turner,T |
| 8/20/2021 | | | HOU | 7 | PLU | 1 | Buehler | Glasnow | | Springer |
| 8/20/2021 | | | SCA | 11 | NHH | 7 | Romo | Quantrill | | Yelich |
| 8/20/2021 | | | CCC | 3 | BEA | 5 | Paddack | Marquez,G | Lakins | Trout |
| 8/20/2021 | | | ISO | 1 | PAN | 10 | Duffy | Darvish | | Rengifo |
| 8/20/2021 | | | LTR | 12 | CYC | 4 | Ponce | Means | | Tellez |
| 8/20/2021 | | | PHS | 4 | GOT | 1 | Giolito | Lester | Gerber | Mondesi |
| 8/20/2021 | | | WHC | 5 | BOM | 10 | Hendricks | Voth | | Schoop |
| 8/20/2021 | | | JOT | 10 | SEA | 5 | Odorizzi | Mahle | Castro,M | Cabrera,A |
| 8/20/2021 | | | COL | 13 | ATK | 6 | Pagan | Treinen | | Lamb |
| 8/20/2021 | | | LVB | 7 | NUT | 5 | Harris | Senzatela | Adam | Naquin |
| 8/21/2021 | | | JER | 4 | PUR | 5 | Scrubb | Brewer | | Severino |
| 8/21/2021 | | | LAH | 13 | SMC | 0 | Keller,M | Anderson,I | Slegers | Voit |
| 8/21/2021 | | | HOU | 1 | PLU | 5 | Holder | Gausman | | Garneau |
| 8/21/2021 | | | SCA | 4 | NHH | 1 | Cole,G | Vincent | Wood | Bogaerts |
| 8/21/2021 | | | CCC | 8 | BEA | 4 | Ryu | Sanchez,An | | Myers |
| 8/21/2021 | | | ISO | 17 | PAN | 5 | Wainwright | LeBlanc | | Cano |
| 8/21/2021 | | 11 | LTR | 2 | CYC | 1 | Garcia,Y | Almonte,Y | | Garcia,LV |
| 8/21/2021 | | | PHS | 7 | GOT | 5 | Cueto | Kershaw | Gerber | Mondesi |
| 8/21/2021 | | | WHC | 4 | BOM | 14 | Wheeler | Keller,B | | Stallings |
| 8/21/2021 | | | JOT | 8 | SEA | 2 | McCullers | Morton | Castro,M | Cabrera,A |
| 8/21/2021 | | 10 | COL | 2 | ATK | 1 | Peralta,F | Tomlin | | Turner,J |
| 8/21/2021 | | | LVB | 0 | NUT | 3 | Perez,Ma | Castellani | Yardley | Bohm |
| 8/22/2021 | | | PUR | 3 | JER | 5 | Howard,Sa | Freeland | | Alonso |
| 8/22/2021 | | 22 | SMC | 5 | LAH | 6 | Dolis | Detwiler | | Voit |
| 8/22/2021 | | | PLU | 0 | HOU | 4 | Gallen | Gibson | | Seager,K |
| 8/22/2021 | | | NHH | 6 | SCA | 2 | Pineda | Turnbull | | Barnes,A |
| 8/22/2021 | | | BEA | 9 | CCC | 2 | Thompson | Diaz,Ed | | Judge |
| 8/22/2021 | | | PAN | 0 | ISO | 8 | Kim | Dunn | | Betts |
| 8/22/2021 | | 10 | CYC | 4 | LTR | 5 | Curtiss | Bass | | Tellez |
| 8/22/2021 | | | GOT | 4 | PHS | 7 | Bailey,B | Hernandez,J | Rainey | Mondesi |
| 8/22/2021 | | | BOM | 4 | WHC | 1 | Urias,J | Plesac | Colome | Schoop |
| 8/22/2021 | | | SEA | 1 | JOT | 3 | Flaherty | Bassitt | Alcala | Ramos,W |
| 8/22/2021 | | | ATK | 4 | COL | 10 | Gant | Yarbrough | | Turner,J |
| 8/22/2021 | | | NUT | 1 | LVB | 2 | Rogers,Tr | Fedde | Stratton | Santander |
| 8/23/2021 | | | PUR | 10 | JER | 9 | Finnegan | Howard,Sa | Jeffress | Hernandez,T |
| 8/23/2021 | | | SMC | 3 | LAH | 5 | Castillo,L | Berrios | | Ramirez,J |
| 8/23/2021 | | | PLU | 2 | HOU | 7 | Lamet | Kelly,M | Smyly | Walker,C |
| 8/23/2021 | | | NHH | 4 | SCA | 6 | Boyd | Gray,J | Petit | Guerrero |
| 8/23/2021 | | | BEA | 1 | CCC | 16 | Valdez,F | Porcello | | Cruz,N |
| 8/23/2021 | | | PAN | 5 | ISO | 6 | Cobb | Hudson,Dan | Antone | Betts |
| 8/23/2021 | | | CYC | 6 | LTR | 2 | Happ,JA | Peterson,D | | Gonzalez,E |
| 8/23/2021 | | | GOT | 3 | PHS | 5 | Arrieta | Tanaka | Gerber | Cave |
| 8/23/2021 | | | BOM | 3 | WHC | 0 | Suter | Sheffield | Colome | |
| 8/23/2021 | | | SEA | 4 | JOT | 3 | Snell | Bumgarner | Chafin | Lopes,T |
| 8/23/2021 | | | ATK | 2 | COL | 5 | Lindblom | Fried | Peralta,F | Tsutsugo |
| 8/23/2021 | | 13 | NUT | 2 | LVB | 1 | Sadler | Garcia,LH | | Urias,L |
| 8/24/2021 | | | PUR | 3 | JER | 0 | Benjamin | Singer | Jeffress | Gamel |
| 8/24/2021 | | | SMC | 0 | LAH | 7 | Keuchel | Lugo,S | | Nimmo |
| 8/24/2021 | | | PLU | 0 | HOU | 3 | Bauer | Gonsolin | Foster | Taylor,M |
| 8/24/2021 | | | NHH | 8 | SCA | 15 | Jimenez,J | Wojciechowski | | Eaton |
| 8/24/2021 | | | BEA | 6 | CCC | 3 | Bundy | Lynn | Jansen,K | Harper,B |
| 8/24/2021 | | | PAN | 2 | ISO | 8 | Maeda | Civale | | Mountcastle |
| 8/24/2021 | | | CYC | 2 | LTR | 6 | Lopez,P | Anderson,Bre | | Tellez |
| 8/24/2021 | | | GOT | 8 | PHS | 1 | Gray,S | Lopez,R | | Gregorius |
| 8/24/2021 | | | BOM | 9 | WHC | 4 | Suter | Dunning | | Schoop |
| 8/24/2021 | | 11 | SEA | 5 | JOT | 7 | Castro,M | Bielak | | Anderson,Ti |
| 8/24/2021 | | | ATK | 0 | COL | 6 | Greinke | Wilson,B | | Narvaez |
| 8/24/2021 | | | NUT | 6 | LVB | 4 | Pivetta | Cease | Neris | Carlson |
| 8/26/2021 | | | CYC | 0 | GOT | 2 | Lester | Means | Rodriguez,Joe | Grisham |
| 8/26/2021 | | | SMC | 2 | NHH | 1 | Gonzales | Brault | Melancon | |
| 8/26/2021 | | | PAN | 0 | ATK | 3 | Gonzalez,C | Duffy | McGee | Pham |
| 8/26/2021 | | | BOM | 3 | PLU | 8 | Peralta,W | Hendricks | | Garneau |
| 8/26/2021 | | | BEA | 19 | SEA | 4 | Paddack | Mahle | Hatch | Smith,WD |
| 8/26/2021 | | | PUR | 4 | NUT | 5 | Senzatela | Canning | Yardley | Gallo |
| 8/27/2021 | | | CYC | 4 | GOT | 2 | Strahm | Kershaw | Bass | Locastro |
| 8/27/2021 | | | SMC | 7 | NHH | 14 | Minor | Luzardo | | Frazier,T |
| 8/27/2021 | | | PAN | 4 | ATK | 2 | LeBlanc | Braymer | Trivino | McNeil |
| 8/27/2021 | | | BOM | 4 | PLU | 5 | Holder | Wendelken | | Garneau |
| 8/27/2021 | | | BEA | 11 | SEA | 2 | Nelson,N | Chafin | Fry,P | Molina |
| 8/27/2021 | | | PUR | 3 | NUT | 5 | Perez,Ma | Ray | Yardley | Sano |
| 8/28/2021 | | | CYC | 6 | GOT | 5 | Strahm | Familia | Bass | Albies |
| 8/28/2021 | | 11 | SMC | 4 | NHH | 3 | Melancon | Quantrill | | Hampson |
| 8/28/2021 | | | PAN | 3 | ATK | 5 | Graterol | Dunn | McGee | Franco |
| 8/28/2021 | | | BOM | 6 | PLU | 4 | Urias,J | Sanchez,S | Colome | Marte,S |
| 8/28/2021 | | | BEA | 6 | SEA | 2 | Porcello | Bassitt | | McCutchen |
| 8/28/2021 | | | PUR | 1 | NUT | 2 | Fedde | Webb,L | Sadler | Bohm |
| 8/29/2021 | | | GOT | 2 | PAN | 9 | Castano | Margevicius | | McNeil |
| 8/29/2021 | | | CYC | 11 | ATK | 8 | Happ,JA | Montgomery,J | | Gurriel,Y |
| 8/29/2021 | | | SMC | 7 | SEA | 4 | Lugo,S | Snell | Melancon | Hampson |
| 8/29/2021 | | 13 | PLU | 5 | PUR | 6 | Scrubb | Rogers,Ty | | Dozier,H |
| 8/29/2021 | | | BOM | 3 | NUT | 1 | Ponce de Leon | Javier | Colome | Dickerson,A |
| 8/29/2021 | | | NHH | 3 | BEA | 6 | Hatch | Gray,J | Jansen,K | Harper,B |
| 8/30/2021 | | | GOT | 5 | PAN | 6 | Bleier | Hernandez,J | | Moreland |
| 8/30/2021 | | | CYC | 9 | ATK | 8 | Anderson,Bre | Gonzalez,C | Bass | Gyorko |
| 8/30/2021 | | | SMC | 5 | SEA | 4 | Berrios | Carrasco | Melancon | Hampson |
| 8/30/2021 | | | PLU | 3 | PUR | 4 | Finnegan | Beeks | Diekman | Renfroe |
| 8/30/2021 | | | BOM | 4 | NUT | 3 | Wendelken | Yardley | Colome | Schoop |
| 8/30/2021 | | | NHH | 5 | BEA | 16 | Mize | Nova | | Chapman,M |
| 8/31/2021 | | 14 | GOT | 3 | PAN | 6 | Watson | Smith,WM | | Garcia,Jo |
| 8/31/2021 | | | CYC | 3 | ATK | 5 | Williams,D | Means | Treinen | Pham |
| 8/31/2021 | | | SMC | 9 | SEA | 7 | Matzek | Stammen | Melancon | d'Arnaud |
| 8/31/2021 | | | PLU | 2 | PUR | 3 | Staumont | Holder | | Grichuk |
| 8/31/2021 | | | BOM | 1 | NUT | 4 | Senzatela | Hendricks | Yardley | Sano |
| 8/31/2021 | | | NHH | 3 | BEA | 8 | Bundy | Brault | | Trout |
| 9/2/2021 | | | JER | 1 | GOT | 5 | Gray,S | Junis | | Laureano |
| 9/2/2021 | | | LAH | 9 | PAN | 2 | Woodruff | LeBlanc | Ramirez,E | Ramirez,J |
| 9/2/2021 | | | HOU | 8 | SEA | 0 | Burnes | Snell | | Tatis |
| 9/2/2021 | | | SCA | 8 | ATK | 5 | Cole,G | Yarbrough | Jimenez,J | Muncy |
| 9/2/2021 | | | CCC | 1 | PLU | 4 | Phelps | Cisnero | Rogers,Ty | Inciarte |
| 9/2/2021 | | | ISO | 5 | NHH | 6 | Quantrill | Antone | | Freeman,M |
| 9/2/2021 | | | LTR | 9 | PUR | 7 | Dobnak | Freeland | Duffey | France |
| 9/2/2021 | | | PHS | 3 | NUT | 13 | Howard,Sp | Arrieta | | Gallo |
| 9/2/2021 | | | WHC | 0 | BEA | 3 | Paddack | Hernandez,El | Fry,P | Stephenson,T |
| 9/2/2021 | | | JOT | 7 | BOM | 1 | Newcomb | Ponce de Leon | | |
| 9/2/2021 | | 15 | COL | 2 | SMC | 3 | Melancon | Pagan | | Hampson |
| 9/2/2021 | | | LVB | 3 | CYC | 5 | Mills | Castellani | Pressly | Panik |
| 9/3/2021 | | | JER | 5 | GOT | 8 | Kershaw | Montas | | Laureano |
| 9/3/2021 | | 10 | LAH | 6 | PAN | 3 | Hendriks | Hudson,Dan | Dolis | Voit |
| 9/3/2021 | | | HOU | 13 | SEA | 0 | Gallen | Carrasco | | Walker,C |
| 9/3/2021 | | | SCA | 9 | ATK | 5 | Turnbull | Mejia,H | | Castro,S |
| 9/3/2021 | | | CCC | 8 | PLU | 1 | Nola,Aa | Sanchez,S | | Myers |
| 9/3/2021 | | | ISO | 7 | NHH | 3 | Darvish | Gomber | | Contreras,WE |
| 9/3/2021 | | | LTR | 6 | PUR | 8 | Richards,T | Fiers | Jeffress | La Stella |
| 9/3/2021 | | | PHS | 5 | NUT | 7 | Fedde | Giolito | Boxberger | Carlson |
| 9/3/2021 | | | WHC | 7 | BEA | 6 | Voth | Porcello | Sims | Smith,Dw |
| 9/3/2021 | | | JOT | 2 | BOM | 8 | Yajure | Toussaint | Rodriguez,R | Phillips,B |
| 9/3/2021 | | | COL | 5 | SMC | 13 | Berrios | Greinke | | Abreu,J |
| 9/3/2021 | | | LVB | 3 | CYC | 4 | Garcia,Ja | Adam | | Rosario,E |
| 9/4/2021 | | | JER | 9 | GOT | 4 | Roark | Lester | Britton | McMahon |
| 9/4/2021 | | | LAH | 12 | PAN | 1 | Keuchel | Castano | | Nimmo |
| 9/4/2021 | | | HOU | 15 | SEA | 2 | Lamet | Bielak | | Tatis |
| 9/4/2021 | | | SCA | 1 | ATK | 9 | Gonzalez,C | Bubic | | Gosselin |
| 9/4/2021 | | | CCC | 10 | PLU | 5 | Valdez,F | Gibson | | Myers |
| 9/4/2021 | | | ISO | 11 | NHH | 8 | Scott | Quantrill | Shreve | Betts |
| 9/4/2021 | | | LTR | 5 | PUR | 2 | Peterson,D | Webb,L | | Soto,J |
| 9/4/2021 | | 10 | PHS | 2 | NUT | 3 | Boxberger | Barria | | Longoria |
| 9/4/2021 | | | WHC | 6 | BEA | 4 | Keller,B | Sanchez,An | Sims | Frazier,A |
| 9/4/2021 | | | JOT | 1 | BOM | 7 | Houser | Alcantara,Sa | | Schoop |
| 9/4/2021 | | | COL | 8 | SMC | 10 | Loup | Sandoval,Pat | Melancon | Dietrich |
| 9/4/2021 | | | LVB | 3 | CYC | 7 | Happ,JA | Cease | | Bradley,J |
| 9/6/2021 | | | GOT | 4 | JER | 3 | Familia | Brewer | Green | Aguilar |
| 9/6/2021 | | | PAN | 0 | LAH | 6 | Houck | Civale | | Voit |
| 9/6/2021 | | | SEA | 2 | HOU | 4 | Bauer | Bielak | Rosenthal | Segura |
| 9/6/2021 | | | ATK | 5 | SCA | 4 | Wilson,B | Diaz,J | McGee | Franco |
| 9/6/2021 | | | PLU | 1 | CCC | 3 | Lynn | Kelly,M | | Ozuna |
| 9/6/2021 | | | NHH | 2 | ISO | 8 | Kim | Nova | | Contreras,WE |
| 9/6/2021 | | | PUR | 6 | LTR | 1 | Hudson,Dak | Lopez,P | Finnegan | Piscotty |
| 9/6/2021 | | | NUT | 7 | PHS | 15 | Anderson,N | Howard,Sp | | Schwarber |
| 9/6/2021 | | | BEA | 0 | WHC | 2 | Plesac | Mize | Sims | Smith,Dw |
| 9/6/2021 | | | BOM | 11 | JOT | 3 | deGrom | Newcomb | | Stallings |
| 9/6/2021 | | | SMC | 0 | COL | 1 | Lyles | Luzardo | O'Day | Escobar |
| 9/6/2021 | | | CYC | 6 | LVB | 4 | Anderson,Bre | Akin | Pressly | Casali |
| 9/7/2021 | | | GOT | 6 | JER | 4 | Kuhl | Gonzalez,G | Green | Gregorius |
| 9/7/2021 | | | PAN | 3 | LAH | 6 | Woodruff | Duffy | Chapman,A | Nimmo |
| 9/7/2021 | | | SEA | 0 | HOU | 17 | Buehler | Morton | | Tucker,K |
| 9/7/2021 | | | ATK | 3 | SCA | 8 | Boyd | Mejia,H | | Pollock |
| 9/7/2021 | | | PLU | 8 | CCC | 10 | Cisnero | Givens | | Candelario |
| 9/7/2021 | | | NHH | 3 | ISO | 10 | Eovaldi | Minor | | Iglesias,J |
| 9/7/2021 | | | PUR | 7 | LTR | 9 | Duffey | Scrubb | Garcia,Y | Kemp,T |
| 9/7/2021 | | 12 | NUT | 3 | PHS | 1 | Boxberger | Feyereisen | Yardley | Carlson |
| 9/7/2021 | | | BEA | 4 | WHC | 2 | Bundy | Sheffield | Jansen,K | Harper,B |
| 9/7/2021 | | | BOM | 6 | JOT | 2 | Hendricks | Bieber | | Goldschmidt |
| 9/7/2021 | | | SMC | 10 | COL | 6 | Detwiler | Gant | Matzek | Riley |
| 9/7/2021 | | | CYC | 6 | LVB | 4 | Means | Castellani | Pressly | Wolters |
| 9/8/2021 | | | GOT | 5 | JER | 0 | Gray,S | Montas | | Gregorius |
| 9/8/2021 | | | PAN | 4 | LAH | 7 | Castillo,L | Fulmer,C | Hendriks | Knapp |
| 9/8/2021 | | | SEA | 2 | HOU | 8 | Burnes | Bassitt | | Seager,K |
| 9/8/2021 | | | ATK | 11 | SCA | 3 | Montgomery,J | Wright | | Yastrzemski |
| 9/8/2021 | | | PLU | 1 | CCC | 4 | Ryu | Davies | Cisnero | Ozuna |
| 9/8/2021 | | | NHH | 1 | ISO | 11 | Wainwright | Wojciechowski | | Freeman,F |
| 9/8/2021 | | | PUR | 4 | LTR | 3 | Ramirez,Y | Taylor,Bl | Jeffress | Hernandez,T |
| 9/8/2021 | | | NUT | 1 | PHS | 9 | Arrieta | Perez,Ma | | Maldonado |
| 9/8/2021 | | | BEA | 4 | WHC | 3 | Paddack | Dunning | Jansen,K | Trout |
| 9/8/2021 | | | BOM | 0 | JOT | 6 | McCullers | Ponce de Leon | Garcia,Ro | Bader |
| 9/8/2021 | | | SMC | 8 | COL | 3 | Gonzales | Greinke | Melancon | Riley |
| 9/8/2021 | | | CYC | 7 | LVB | 10 | Hearn | Pressly | | Suarez,E |
| 9/9/2021 | | | GOT | 10 | PLU | 0 | Kershaw | Gibson | Familia | Aguilar |
| 9/9/2021 | | 11 | BOM | 6 | CYC | 7 | Bass | Hader | | Rosario,E |
| 9/9/2021 | | | ATK | 11 | SMC | 4 | Karinchak | Crichton | | Holaday |
| 9/9/2021 | | | PAN | 3 | NHH | 2 | Musgrove | Gomber | Kline | Robert |
| 9/9/2021 | | | SEA | 1 | NUT | 2 | Borucki | Kimbrel | Boxberger | Calhoun,K |
| 9/9/2021 | | | BEA | 4 | PUR | 16 | Diekman | Porcello | | Hernandez,T |
| 9/10/2021 | | | GOT | 8 | PLU | 2 | Lester | DeSclafani | | Grisham |
| 9/10/2021 | | | BOM | 5 | CYC | 3 | Castillo,D | Means | Colome | Schoop |
| 9/10/2021 | | 12 | ATK | 5 | SMC | 6 | Lugo,S | Lorenzen | | Anderson,Bri |
| 9/10/2021 | | | PAN | 2 | NHH | 1 | Castano | Gray,J | Kline | Robert |
| 9/10/2021 | | | SEA | 7 | NUT | 1 | Carrasco | Javier | | Alberto |
| 9/10/2021 | | | BEA | 7 | PUR | 8 | Webb,L | Sanchez,An | Floro | Hernandez,T |
| 9/11/2021 | | 11 | GOT | 6 | PLU | 5 | Green | Hughes | Garrett,A | Caratini |
| 9/11/2021 | | | BOM | 1 | CYC | 14 | Happ,JA | deGrom | | |
| 9/11/2021 | | | ATK | 5 | SMC | 12 | Oswalt | Mejia,H | Detwiler | Anderson,Bri |
| 9/11/2021 | | | PAN | 4 | NHH | 2 | Civale | Nova | Kline | Moreland |
| 9/11/2021 | | | SEA | 7 | NUT | 6 | Kimbrel | Boxberger | Plutko | Blackmon |
| 9/11/2021 | | | BEA | 0 | PUR | 1 | Hudson,Dak | Mize | Diekman | La Stella |
| 9/12/2021 | | | ATK | 2 | SMC | 5 | Heuer | Fried | Melancon | Quinn |
| 9/12/2021 | | | PAN | 0 | NHH | 3 | Minor | Duffy | | Bote |
| 9/13/2021 | | | PLU | 5 | GOT | 6 | Johnson,P | Givens | | Caratini |
| 9/13/2021 | | | CYC | 3 | BOM | 2 | Means | Hendricks | Garcia,B | Albies |
| 9/13/2021 | | | SMC | 6 | ATK | 2 | Walker,T | Gonzalez,C | | Abreu,J |
| 9/13/2021 | | 10 | NHH | 8 | PAN | 9 | Watson | Quantrill | | |
| 9/13/2021 | | | NUT | 3 | SEA | 4 | Stammen | Senzatela | Kimbrel | Marmolejos |
| 9/13/2021 | | | PUR | 4 | BEA | 5 | Jansen,K | Finnegan | | Stephenson,T |
| 9/14/2021 | | | PLU | 2 | GOT | 4 | Baez,P | Phelps | | Arenado |
| 9/14/2021 | | | CYC | 11 | BOM | 6 | Mills | Ponce de Leon | | Cabrera,M |
| 9/14/2021 | | | SMC | 11 | ATK | 5 | Hale | Hernandez,Ca | | |
| 9/14/2021 | | | NHH | 5 | PAN | 1 | Gomber | Dunn | Newberry | Margot |
| 9/14/2021 | | | NUT | 7 | SEA | 4 | Perez,Ma | Morton | Boxberger | Longoria |
| 9/14/2021 | | | PUR | 5 | BEA | 1 | Freeland | Paddack | | Grichuk |
| 9/15/2021 | | 10 | PLU | 3 | GOT | 4 | Green | Zuber | | Aguilar |
| 9/15/2021 | | | CYC | 3 | BOM | 1 | Heaney | Chirinos,Y | Garcia,Ja | Albies |
| 9/15/2021 | | | SMC | 5 | ATK | 1 | Gonzales | Mejia,H | | Grossman |
| 9/15/2021 | | 14 | NHH | 3 | PAN | 5 | Thornburg | Vincent | | Kiner-Falefa |
| 9/15/2021 | | | NUT | 7 | SEA | 8 | Stammen | Boxberger | | Encarnacion |
| 9/15/2021 | | | PUR | 2 | BEA | 8 | Porcello | Richards,T | | Naylor |
| 9/16/2021 | | | PUR | 1 | GOT | 4 | Lester | Webb,L | | Smith,Do |
| 9/16/2021 | | 10 | NUT | 3 | CYC | 4 | Strahm | Boxberger | | |
| 9/16/2021 | | 11 | SMC | 1 | BOM | 0 | Greene | Colome | Heuer | Biggio |
| 9/16/2021 | | | PAN | 6 | BEA | 3 | Civale | Sanchez,An | Kline | Chirinos,R |
| 9/16/2021 | | | PLU | 8 | NHH | 5 | Kelly,M | Nova | | Smoak |
| 9/16/2021 | | | SEA | 4 | ATK | 6 | Montgomery,J | Carrasco | Martin,C | Gonzalez,M |
| 9/17/2021 | | | PUR | 3 | GOT | 2 | Hudson,Dak | Smith,C | Scrubb | Walsh |
| 9/17/2021 | | | NUT | 6 | CYC | 1 | Manaea | Anderson,Bre | | Longoria |
| 9/17/2021 | | 10 | SMC | 4 | BOM | 5 | Hill,C | Matzek | | Peterson,J |
| 9/17/2021 | | | PAN | 6 | BEA | 8 | Hunter | Thornburg | Jansen,K | Cron,CJ |
| 9/17/2021 | | | PLU | 2 | NHH | 1 | Gonsolin | Minor | Peralta,W | Brinson |
| 9/17/2021 | | | SEA | 4 | ATK | 9 | Skubal | Bielak | | Gonzalez,M |
| 9/18/2021 | | | PUR | 4 | GOT | 6 | Garrett,A | Mengden | Green | Nola,Au |
| 9/18/2021 | | | NUT | 2 | CYC | 1 | Senzatela | Means | Boxberger | Bohm |
| 9/18/2021 | | | SMC | 1 | BOM | 4 | Wheeler | Walker,T | Rodriguez,R | Rojas,J |
| 9/18/2021 | | | PAN | 1 | BEA | 4 | Bundy | LeBlanc | Jansen,K | Flores,W |
| 9/18/2021 | | | PLU | 3 | NHH | 4 | Vincent | Holder | Quantrill | Bote |
| 9/18/2021 | | | SEA | 4 | ATK | 10 | Hernandez,Ca | Morton | | Franco |
| 9/19/2021 | | | PUR | 6 | GOT | 8 | Gray,S | Freeland | Green | Nunez,R |
| 9/19/2021 | | 10 | NUT | 5 | CYC | 6 | Wilson,J | Neris | | Panik |
| 9/20/2021 | | | GOT | 5 | PUR | 4 | Kershaw | Freeland | Green | Caratini |
| 9/20/2021 | | | CYC | 9 | NUT | 4 | Heaney | Borucki | Pressly | Albies |
| 9/20/2021 | | | BOM | 6 | SMC | 8 | Detwiler | Ponce de Leon | Melancon | Riley |
| 9/20/2021 | | | BEA | 7 | PAN | 2 | Paddack | Musgrove | | Harper,B |
| 9/20/2021 | | | NHH | 2 | PLU | 5 | Davies | Gomber | | Bregman |
| 9/20/2021 | | | ATK | 4 | SEA | 1 | Mejia,H | Morton | McGee | Yastrzemski |
| 9/21/2021 | | | GOT | 1 | PUR | 4 | Diekman | Lester | Jeffress | Grichuk |
| 9/21/2021 | | | CYC | 3 | NUT | 0 | Happ,JA | Javier | | Cabrera,M |
| 9/21/2021 | | | BOM | 3 | SMC | 5 | Berrios | Chirinos,Y | Melancon | Riley |
| 9/21/2021 | | | BEA | 1 | PAN | 4 | Castano | Porcello | Kline | Kiner-Falefa |
| 9/21/2021 | | | NHH | 7 | PLU | 5 | Smith,JA | Gibson | Quantrill | Bote |
| 9/21/2021 | | | ATK | 6 | SEA | 0 | Fried | Jurado | Yarbrough | Yastrzemski |
| 9/22/2021 | | | GOT | 3 | PUR | 1 | Alzolay | Webb,L | Green | Nola,Au |
| 9/22/2021 | | | CYC | 9 | NUT | 2 | Anderson,Bre | Manaea | | Casali |
| 9/22/2021 | | | BOM | 3 | SMC | 7 | Oswalt | Houser | | Peraza |
| 9/22/2021 | | | BEA | 2 | PAN | 4 | Civale | Sanchez,An | Kline | |
| 9/22/2021 | | | NHH | 14 | PLU | 3 | Pineda | Kelly,M | | Bote |
| 9/22/2021 | | | ATK | 6 | SEA | 5 | Yarbrough | Kimbrel | McGee | Franco |
| 9/23/2021 | | | GOT | 1 | NHH | 6 | Wojciechowski | Smith,C | | Lewis |
| 9/23/2021 | | | CYC | 6 | SMC | 7 | May,T | Pressly | | Anderson,Bri |
| 9/23/2021 | | | PAN | 4 | PUR | 9 | Benjamin | Thornburg | Ramirez,Y | La Stella |
| 9/23/2021 | | | PLU | 12 | BEA | 5 | Gonsolin | Mize | | Varsho |
| 9/23/2021 | | | BOM | 7 | SEA | 2 | deGrom | Carrasco | Rodriguez,R | Rojas,J |
| 9/23/2021 | | | NUT | 13 | ATK | 1 | Senzatela | Gonzalez,C | | Gallo |
| 9/24/2021 | | | GOT | 7 | NHH | 3 | Rodriguez,Joe | Quantrill | | Nola,Au |
| 9/24/2021 | | | CYC | 3 | SMC | 5 | Loup | Garcia,Ja | Melancon | d'Arnaud |
| 9/24/2021 | | | PAN | 0 | PUR | 11 | Hudson,Dak | Dunn | | Piscotty |
| 9/24/2021 | | 13 | PLU | 10 | BEA | 6 | Peralta,W | Velasquez | | Dickerson,C |
| 9/24/2021 | | | BOM | 14 | SEA | 1 | Hendricks | Bielak | | Story |
| 9/24/2021 | | | NUT | 18 | ATK | 0 | Perez,Ma | Mejia,H | | Gallo |
| 9/25/2021 | | | GOT | 3 | NHH | 1 | Kershaw | Nova | Green | Aguilar |
| 9/25/2021 | | | CYC | 3 | SMC | 7 | Berrios | Heaney | | Simmons |
| 9/25/2021 | | | PAN | 0 | PUR | 5 | Freeland | Musgrove | | Hernandez,T |
| 9/25/2021 | | | PLU | 8 | BEA | 4 | Davies | Paddack | | Moncada |
| 9/25/2021 | | | BOM | 2 | SEA | 4 | Morton | Ponce de Leon | Stammen | Alberto |
| 9/25/2021 | | | NUT | 10 | ATK | 6 | Fedde | Montgomery,J | | Gallo |
| 9/27/2021 | | | BEA | 3 | PLU | 12 | Gibson | Porcello | | Jeffers |
| 9/27/2021 | | | SEA | 5 | BOM | 3 | Snell | Chirinos,Y | Stammen | Alberto |
| 9/28/2021 | | | NHH | 3 | GOT | 11 | Lester | Wojciechowski | | Gregorius |
| 9/28/2021 | | | SMC | 3 | CYC | 10 | Happ,JA | Luzardo | | Gurriel,Y |
| 9/28/2021 | | 14 | PUR | 1 | PAN | 2 | Fulmer,C | Scrubb | | Rosario,A |
| 9/28/2021 | | 10 | BEA | 12 | PLU | 5 | Hunter | Underwood | | Trout |
| 9/28/2021 | | | SEA | 2 | BOM | 8 | Houser | Carrasco | Hader | Goldschmidt |
| 9/28/2021 | | | ATK | 9 | NUT | 3 | Dayton | Borucki | | Gosselin |
| 9/29/2021 | | | NHH | 3 | GOT | 10 | Familia | Gray,J | | Nunez,R |
| 9/29/2021 | | | SMC | 2 | CYC | 4 | Anderson,Bre | Gonzales | Pressly | Gonzalez,E |
| 9/29/2021 | | | PUR | 1 | PAN | 4 | Civale | Hudson,Dak | Kline | Rosario,A |
| 9/29/2021 | | | BEA | 6 | PLU | 12 | Gonsolin | Mize | | Altuve |
| 9/29/2021 | | | SEA | 1 | BOM | 5 | Wheeler | Bielak | | Winker |
| 9/29/2021 | | | ATK | 1 | NUT | 3 | Manaea | Fried | Boxberger | Fletcher,D |
| 9/30/2021 | | | NHH | 7 | GOT | 10 | Hernandez,J | Vincent | Green | Nunez,R |
| 9/30/2021 | | | SMC | 4 | CYC | 2 | Walker,T | Heaney | Heuer | Hampson |
| 9/30/2021 | | | PUR | 4 | PAN | 3 | Canning | Duffy | Diekman | Gamel |
| 9/30/2021 | | | BEA | 6 | PLU | 4 | Bundy | Glasnow | Jansen,K | Trout |
| 9/30/2021 | | | SEA | 6 | BOM | 3 | Morton | Hendricks | Plutko | Lopes,T |
| 9/30/2021 | | | ATK | 3 | NUT | 7 | Mazza | Mejia,H | | Calhoun,K |