League game results -- American
Regular season
| Results |
| Date | # | Inn | Away | R | Home | R | Win | Loss | Save | GWRBI |
| 4/1/2021 | | | JER | 2 | PHS | 0 | Singer | Cahill | Iglesias,R | Perez,S |
| 4/1/2021 | | | COL | 1 | LAH | 4 | Woodruff | Greinke | Hendriks | Vazquez |
| 4/1/2021 | | | CCC | 2 | HOU | 5 | Marshall | Reid-Foley | Hahn | Segura |
| 4/1/2021 | | 11 | ISO | 6 | SCA | 3 | Antone | Montero | Raley | Stevenson |
| 4/1/2021 | | | LVB | 7 | LTR | 8 | Garcia,Y | Robles,H | | Tellez |
| 4/1/2021 | | | JOT | 5 | WHC | 4 | Bieber | Voth | Castro,M | Peralta,D |
| 4/2/2021 | | | JER | 3 | PHS | 4 | Anderson,N | Iglesias,R | | Joyce |
| 4/2/2021 | | | COL | 3 | LAH | 5 | Castillo,L | Gant | Hendriks | Meadows |
| 4/2/2021 | | 12 | CCC | 4 | HOU | 3 | Hand | Smyly | Mayers | Ozuna |
| 4/2/2021 | | | ISO | 4 | SCA | 5 | Turnbull | Kim | Romo | Santana,C |
| 4/2/2021 | | | LVB | 2 | LTR | 5 | Fiers | Anderson,Ty | Yates | Rios,E |
| 4/2/2021 | | | JOT | 2 | WHC | 6 | Keller,B | McCullers | | Mullins |
| 4/3/2021 | | | JER | 6 | PHS | 4 | Allard | Brubaker | Gonzalez,V | Perez,S |
| 4/3/2021 | | | COL | 2 | LAH | 5 | Perez,O | Peralta,F | | Taylor,C |
| 4/3/2021 | | | CCC | 2 | HOU | 5 | Lamet | Nola,Aa | | Walker,C |
| 4/3/2021 | | | ISO | 3 | SCA | 11 | Boyd | Clevinger | | Bogaerts |
| 4/3/2021 | | | LVB | 7 | LTR | 6 | Stripling | Eflin | Garcia,LH | Sisco |
| 4/3/2021 | | | JOT | 0 | WHC | 4 | Plesac | Bumgarner | | Frazier,A |
| 4/4/2021 | | 13 | JER | 2 | HOU | 1 | Parker | Marshall | Britton | Lowe,N |
| 4/4/2021 | | | JOT | 1 | LAH | 4 | May,D | Flaherty | Hendriks | |
| 4/4/2021 | | | CCC | 7 | SCA | 3 | Ryu | Bubic | Mayers | Rendon |
| 4/4/2021 | | | ISO | 6 | PHS | 3 | Wainwright | Hernandez,D | Antone | Guillorme |
| 4/4/2021 | | | COL | 0 | LTR | 2 | Dobnak | Quintana | Yates | Tellez |
| 4/4/2021 | | | LVB | 3 | WHC | 10 | Sheffield | Castellani | | Mullins |
| 4/5/2021 | | | JER | 5 | HOU | 7 | Gausman | Junis | Smith,R | Seager,K |
| 4/5/2021 | | 10 | JOT | 7 | LAH | 6 | Cabrera,G | Valdez,C | James | Peralta,D |
| 4/5/2021 | | | CCC | 7 | SCA | 6 | Corbin | Wright | Hand | Lindor |
| 4/5/2021 | | | ISO | 6 | PHS | 0 | Cobb | Cueto | Shreve | Choi |
| 4/5/2021 | | | COL | 4 | LTR | 13 | Peterson,D | Newsome | | Olson |
| 4/5/2021 | | | LVB | 6 | WHC | 10 | Sims | Robles,H | | Hoskins |
| 4/6/2021 | | | JER | 1 | HOU | 4 | Buehler | Singer | Foster | Walker,C |
| 4/6/2021 | | 10 | JOT | 6 | LAH | 7 | Thielbar | Castro,M | | Turner,T |
| 4/6/2021 | | | CCC | 3 | SCA | 4 | Montero | Diaz,Ed | | Bogaerts |
| 4/6/2021 | | | ISO | 7 | PHS | 2 | Darvish | Cahill | | Freeman,F |
| 4/6/2021 | | | COL | 1 | LTR | 2 | Wisler | Gant | | Kemp,T |
| 4/6/2021 | | | LVB | 6 | WHC | 4 | Castellani | Keller,B | Teheran | Goodrum |
| 4/7/2021 | | | JER | 6 | ISO | 5 | Hartlieb | Andriese | Iglesias,R | Reynolds,B |
| 4/7/2021 | | | CCC | 1 | LAH | 5 | Castillo,L | Marquez,G | Ramirez,E | Ramirez,J |
| 4/7/2021 | | | COL | 1 | HOU | 15 | Burnes | Scherzer | | Walker,C |
| 4/7/2021 | | | SCA | 3 | PHS | 4 | Arrieta | Turnbull | Anderson,N | |
| 4/7/2021 | | | LTR | 1 | WHC | 6 | Plesac | Lopez,P | | Pillar |
| 4/7/2021 | | | LVB | 11 | JOT | 4 | Cease | McCullers | | Jimenez,E |
| 4/8/2021 | | | JER | 3 | ISO | 9 | Clevinger | Roark | | Seager,C |
| 4/8/2021 | | | CCC | 2 | LAH | 4 | Keuchel | Lynn | Valdez,C | Merrifield |
| 4/8/2021 | | | COL | 8 | HOU | 2 | Lindblom | Lamet | | Adames |
| 4/8/2021 | | | SCA | 3 | PHS | 5 | Shoemaker | Boyd | Kinley | Schwarber |
| 4/8/2021 | | | LTR | 0 | WHC | 4 | Sheffield | Fiers | | Hoskins |
| 4/8/2021 | | | LVB | 6 | JOT | 8 | Cabrera,G | Stripling | Morejon | Cronenworth |
| 4/9/2021 | | | JER | 2 | ISO | 11 | Wainwright | Montas | | Seager,C |
| 4/9/2021 | | | CCC | 0 | LAH | 3 | Keller,M | Nola,Aa | Hendriks | Swanson,D |
| 4/9/2021 | | | COL | 2 | HOU | 5 | Gallen | Peralta,F | Hahn | Reyes,F |
| 4/9/2021 | | | SCA | 3 | PHS | 8 | Giolito | Buttrey | | Solano |
| 4/9/2021 | | | LTR | 4 | WHC | 6 | Holland,G | Webb,T | Hatch | |
| 4/9/2021 | | | LVB | 2 | JOT | 3 | Morejon | Garcia,LH | | Moustakas |
| 4/11/2021 | | | PHS | 3 | JER | 6 | Junis | Cueto | Iglesias,R | Acuna |
| 4/11/2021 | | | LAH | 14 | COL | 0 | May,D | Greinke | | Dubon |
| 4/11/2021 | | | HOU | 8 | CCC | 1 | Gausman | Ryu | Smith,R | Segura |
| 4/11/2021 | | | SCA | 3 | ISO | 2 | Rogers,Ta | Andriese | Montero | Bellinger |
| 4/11/2021 | | | LTR | 5 | LVB | 4 | Dobnak | Stripling | Webb,T | Kemp,T |
| 4/11/2021 | | | WHC | 10 | JOT | 2 | Keller,B | Alcantara,Sa | | O'Neill |
| 4/12/2021 | | 12 | PHS | 7 | JER | 6 | Anderson,N | Rasmussen | | Diaz,A |
| 4/12/2021 | | | LAH | 9 | COL | 4 | Woodruff | Scherzer | Perez,O | Voit |
| 4/12/2021 | | | HOU | 8 | CCC | 2 | Smyly | Corbin | | Springer |
| 4/12/2021 | | | SCA | 6 | ISO | 0 | Cole,G | Darvish | | Bogaerts |
| 4/12/2021 | | | LTR | 0 | LVB | 1 | Castellani | Peterson,D | Robles,H | Pujols |
| 4/12/2021 | | 12 | WHC | 1 | JOT | 0 | Sims | Alcala | Suero | Mullins |
| 4/13/2021 | | | PHS | 11 | JER | 4 | Arrieta | Valdez,F | | Duvall |
| 4/13/2021 | | | LAH | 5 | COL | 10 | Lindblom | Castillo,L | | Adames |
| 4/13/2021 | | | HOU | 1 | CCC | 0 | Burnes | Richards,G | Hahn | Madrigal |
| 4/13/2021 | | | SCA | 4 | ISO | 3 | Clippard | Antone | Montero | Ohtani |
| 4/13/2021 | | | LTR | 3 | LVB | 4 | Cease | Kikuchi | Garcia,LH | Brinson |
| 4/13/2021 | | | WHC | 5 | JOT | 8 | McCullers | Sheffield | Morejon | Cabrera,A |
| 4/14/2021 | | | PHS | 4 | JER | 10 | Allard | Brubaker | Gonzalez,V | Verdugo |
| 4/14/2021 | | | LAH | 13 | COL | 8 | Hendriks | Newsome | | |
| 4/14/2021 | | | HOU | 8 | CCC | 1 | Lamet | Marquez,G | | Tatis |
| 4/14/2021 | | 10 | SCA | 0 | ISO | 3 | Antone | Cole,AJ | | Freeman,F |
| 4/14/2021 | | | LTR | 7 | LVB | 0 | Lopez,P | Anderson,Ty | | Rojas,M |
| 4/14/2021 | | | WHC | 3 | JOT | 11 | Bumgarner | Voth | Cabrera,G | Villar |
| 4/15/2021 | | | WHC | 5 | JER | 4 | Gallegos | Hartlieb | Suero | Moran,C |
| 4/15/2021 | | | LAH | 5 | LTR | 4 | Garcia,D | Fiers | Dolis | Meadows |
| 4/15/2021 | | | HOU | 3 | COL | 1 | Gallen | Kay | Hahn | |
| 4/15/2021 | | | PHS | 4 | SCA | 7 | Bubic | Giolito | Montero | Bellinger |
| 4/15/2021 | | | ISO | 8 | CCC | 6 | DeSclafani | Lynn | Givens | Freeman,F |
| 4/15/2021 | | | JOT | 3 | LVB | 5 | Stephenson,R | Alcala | | Huff |
| 4/16/2021 | | | WHC | 7 | JER | 9 | Britton | Suero | | Happ,I |
| 4/16/2021 | | | LAH | 10 | LTR | 5 | Slegers | Eflin | | Voit |
| 4/16/2021 | | | HOU | 5 | COL | 4 | Gausman | Greinke | Armstrong | Reyes,F |
| 4/16/2021 | | | PHS | 4 | SCA | 0 | Cueto | Wright | | Duvall |
| 4/16/2021 | | 13 | ISO | 3 | CCC | 4 | Diaz,Ed | Shreve | | Ozuna |
| 4/16/2021 | | | JOT | 1 | LVB | 7 | Akin | Alcantara,Sa | | Jimenez,E |
| 4/17/2021 | | | WHC | 2 | JER | 5 | Gonzalez,V | Sheffield | Iglesias,R | Perez,S |
| 4/17/2021 | | | LAH | 0 | LTR | 6 | Dobnak | Woodruff | | France |
| 4/17/2021 | | | HOU | 11 | COL | 6 | Buehler | Scherzer | | Tucker,K |
| 4/17/2021 | | | PHS | 4 | SCA | 1 | Cody | Cole,G | Anderson,N | Devers |
| 4/17/2021 | | | ISO | 4 | CCC | 6 | Ryu | Shreve | | Cruz,N |
| 4/17/2021 | | | JOT | 5 | LVB | 2 | Bieber | Castellani | | Anderson,Ti |
| 4/18/2021 | | | CCC | 0 | JER | 1 | Valdez,F | Corbin | O'Day | Crawford,JP |
| 4/18/2021 | | | WHC | 3 | LAH | 7 | Castillo,L | Voth | | Voit |
| 4/18/2021 | | | PHS | 5 | HOU | 4 | Arrieta | Burnes | Anderson,N | Schwarber |
| 4/18/2021 | | | SCA | 5 | LVB | 2 | Turnbull | Cease | Montero | Shaw,T |
| 4/18/2021 | | | ISO | 3 | LTR | 6 | Bummer | Kim | Curtiss | Nottingham |
| 4/18/2021 | | | COL | 4 | JOT | 2 | Lindblom | McCullers | Gant | Tsutsugo |
| 4/19/2021 | | | CCC | 4 | JER | 8 | Parker | Richards,G | | Alonso |
| 4/19/2021 | | | WHC | 4 | LAH | 2 | Keller,B | Houck | Soto,G | Galvis |
| 4/19/2021 | | | PHS | 4 | HOU | 8 | Lamet | Brubaker | | Seager,K |
| 4/19/2021 | | | SCA | 4 | LVB | 6 | Stripling | Boyd | | Jimenez,E |
| 4/19/2021 | | | ISO | 7 | LTR | 8 | Zimmer,K | Clevinger | Weems | Vogelbach |
| 4/19/2021 | | | COL | 4 | JOT | 2 | Peralta,F | Bumgarner | Newsome | Adames |
| 4/20/2021 | | | CCC | 4 | JER | 2 | Marquez,G | Montas | Hand | Ozuna |
| 4/20/2021 | | | WHC | 2 | LAH | 6 | Keuchel | Plesac | | Voit |
| 4/20/2021 | | 12 | PHS | 3 | HOU | 4 | Foster | Merryweather | | Springer |
| 4/20/2021 | | | SCA | 10 | LVB | 2 | Bubic | Anderson,Ty | | Trevino |
| 4/20/2021 | | | ISO | 3 | LTR | 7 | Kikuchi | Wainwright | Zimmer,K | Garcia,LV |
| 4/20/2021 | | | COL | 9 | JOT | 8 | Quintana | Castro,M | | Mountcastle |
| 4/21/2021 | | | ISO | 5 | JER | 12 | Maton | Cobb | | Alonso |
| 4/21/2021 | | | LAH | 0 | CCC | 2 | Lynn | Keller,M | Hand | Ozuna |
| 4/21/2021 | | | SCA | 5 | HOU | 3 | Cole,AJ | Armstrong | Montero | Bellinger |
| 4/21/2021 | | | WHC | 4 | LTR | 0 | Sheffield | Peterson,D | | Hoskins |
| 4/21/2021 | | | PHS | 6 | JOT | 2 | Cueto | Alcantara,Sa | | Cave |
| 4/21/2021 | | | COL | 15 | LVB | 1 | Greinke | Teheran | | |
| 4/22/2021 | | 10 | ISO | 3 | JER | 4 | Iglesias,R | Antone | | Happ,I |
| 4/22/2021 | | | LAH | 3 | CCC | 5 | Hand | Paredes,E | | Ozuna |
| 4/22/2021 | | | SCA | 5 | HOU | 2 | Cole,AJ | Smyly | Montero | Pollock |
| 4/22/2021 | | | WHC | 0 | LTR | 4 | Lopez,P | Voth | Taylor,Bl | Olson |
| 4/22/2021 | | | PHS | 19 | JOT | 11 | Merryweather | Bieber | | |
| 4/22/2021 | | | COL | 8 | LVB | 1 | Scherzer | Rogers,Tr | | Tsutsugo |
| 4/23/2021 | | | ISO | 4 | JER | 7 | Gonzalez,V | DeSclafani | Iglesias,R | Semien |
| 4/23/2021 | | | LAH | 5 | CCC | 0 | May,D | Ryu | | Merrifield |
| 4/23/2021 | | | SCA | 2 | HOU | 7 | Burnes | Turnbull | | Springer |
| 4/23/2021 | | | WHC | 11 | LTR | 3 | Keller,B | Fiers | | Galvis |
| 4/23/2021 | | | PHS | 1 | JOT | 4 | Cabrera,G | Merryweather | Castro,M | Frazier,C |
| 4/23/2021 | | | COL | 6 | LVB | 1 | Lindblom | Cease | | Adames |
| 4/25/2021 | | | JER | 3 | WHC | 8 | Plesac | Allard | | Espinal |
| 4/25/2021 | | | LTR | 5 | LAH | 2 | Eflin | Castillo,L | Garcia,Y | Vogelbach |
| 4/25/2021 | | | HOU | 7 | PHS | 0 | Lamet | Shoemaker | | Tatis |
| 4/25/2021 | | | LVB | 1 | SCA | 9 | Boyd | Stripling | | Guerrero |
| 4/25/2021 | | 14 | CCC | 6 | ISO | 7 | Wittgren | Richards,G | | Betts |
| 4/25/2021 | | | JOT | 9 | COL | 5 | Reyes,A | Peralta,F | | Anderson,Ti |
| 4/26/2021 | | | JER | 11 | WHC | 15 | Hatch | Roark | | Frazier,A |
| 4/26/2021 | | | LTR | 3 | LAH | 7 | Keuchel | Dobnak | | Meadows |
| 4/26/2021 | | | HOU | 7 | PHS | 0 | Gallen | Giolito | | Walker,C |
| 4/26/2021 | | | LVB | 3 | SCA | 4 | Montero | Stratton | | Shaw,T |
| 4/26/2021 | | | CCC | 13 | ISO | 5 | Marquez,G | Wainwright | | Hernandez,Ce |
| 4/26/2021 | | | JOT | 6 | COL | 0 | Flaherty | Greinke | Castro,M | Stanton |
| 4/27/2021 | | | JER | 3 | WHC | 6 | Voth | Junis | Suero | O'Neill |
| 4/27/2021 | | | LTR | 1 | LAH | 4 | Dolis | Webb,T | Hendriks | Dubon |
| 4/27/2021 | | | HOU | 2 | PHS | 5 | Cueto | Gausman | Anderson,N | Schwarber |
| 4/27/2021 | | | LVB | 2 | SCA | 5 | Wright | Anderson,Ty | Montero | Yelich |
| 4/27/2021 | | | CCC | 7 | ISO | 14 | Cobb | Lynn | | Donaldson |
| 4/27/2021 | | | JOT | 1 | COL | 5 | Scherzer | Alcantara,Sa | | Adames |
| 4/28/2021 | | | JER | 3 | CCC | 5 | Nola,Aa | Singer | Hand | Stewart,DJ |
| 4/28/2021 | | | LAH | 3 | WHC | 2 | May,D | Keller,B | Hendriks | Vazquez |
| 4/28/2021 | | | HOU | 5 | SCA | 3 | Buehler | Cole,G | Hahn | Kelly,C |
| 4/28/2021 | | | LTR | 2 | ISO | 4 | Darvish | Lopez,P | Antone | Contreras,WE |
| 4/28/2021 | | | JOT | 7 | PHS | 3 | Bieber | Cahill | | Ramos,W |
| 4/28/2021 | | | LVB | 4 | COL | 10 | Lindblom | Akin | | Baez,J |
| 4/29/2021 | | | JER | 13 | CCC | 5 | Parker | Richards,G | | Perez,S |
| 4/29/2021 | | | LAH | 1 | WHC | 3 | Plesac | Garcia,D | Holland,G | Moran,C |
| 4/29/2021 | | 10 | HOU | 5 | SCA | 4 | Hahn | Stashak | | Springer |
| 4/29/2021 | | | LTR | 7 | ISO | 4 | Curtiss | Kim | | Polanco,J |
| 4/29/2021 | | | JOT | 4 | PHS | 2 | McCullers | Arrieta | James | Villar |
| 4/29/2021 | | | LVB | 7 | COL | 4 | Cease | Kay | Garcia,LH | Brinson |
| 4/30/2021 | | 11 | JER | 2 | CCC | 1 | Iglesias,R | Hand | | Perez,S |
| 4/30/2021 | | 12 | LAH | 2 | WHC | 1 | Valdez,C | Gallegos | | Castro,W |
| 4/30/2021 | | | HOU | 8 | SCA | 7 | Minter | Barnes,M | | Machado |
| 4/30/2021 | | | LTR | 3 | ISO | 8 | Antone | Fiers | | Seager,C |
| 4/30/2021 | | | JOT | 3 | PHS | 6 | Brubaker | Bumgarner | Anderson,N | Solano |
| 4/30/2021 | | | LVB | 2 | COL | 6 | Peralta,F | Stripling | | Tsutsugo |
| 5/1/2021 | | | JER | 14 | LVB | 3 | Montas | Castellani | | Happ,I |
| 5/1/2021 | | | LAH | 15 | SCA | 4 | Keuchel | Bubic | Slegers | Swanson,D |
| 5/1/2021 | | | WHC | 3 | HOU | 7 | Gallen | Voth | | Springer |
| 5/1/2021 | | | CCC | 7 | JOT | 10 | Alcala | Corbin | Cabrera,G | Anderson,Ti |
| 5/1/2021 | | | ISO | 8 | COL | 4 | Wainwright | Greinke | Antone | Seager,C |
| 5/1/2021 | | 13 | LTR | 2 | PHS | 3 | Merryweather | Weems | | Diaz,A |
| 5/2/2021 | | | JER | 4 | LVB | 3 | Junis | Anderson,Ty | Gonzalez,V | Verdugo |
| 5/2/2021 | | | LAH | 15 | SCA | 2 | Woodruff | Wright | | Castro,W |
| 5/2/2021 | | 11 | WHC | 2 | HOU | 3 | Smith,R | Soto,G | | Tatis |
| 5/2/2021 | | | CCC | 4 | JOT | 3 | Marquez,G | Reyes,A | Mayers | Rendon |
| 5/2/2021 | | | ISO | 5 | COL | 3 | Cobb | Scherzer | Harvey,H | |
| 5/2/2021 | | | LTR | 5 | PHS | 1 | Eflin | Cueto | | Soto,J |
| 5/3/2021 | | | JER | 2 | LVB | 1 | Gonzalez,V | Burdi,Z | | Lowe,N |
| 5/3/2021 | | | LAH | 4 | SCA | 2 | Keller,M | Cole,G | Hendriks | Merrifield |
| 5/3/2021 | | | WHC | 1 | HOU | 2 | Buehler | Plesac | Hahn | Kelly,C |
| 5/3/2021 | | | CCC | 4 | JOT | 3 | Lynn | Cabrera,G | Cisnero | |
| 5/3/2021 | | | ISO | 5 | COL | 11 | Lindblom | Darvish | | Canha |
| 5/3/2021 | | | LTR | 1 | PHS | 2 | Merryweather | Curtiss | Hernandez,D | Duvall |
| 5/4/2021 | | | JER | 0 | NUT | 3 | Senzatela | Valdez,F | Dayton | Gallo |
| 5/4/2021 | | | LAH | 5 | NHH | 6 | Smeltzer | Dolis | Quantrill | Lewis |
| 5/4/2021 | | | HOU | 5 | BOM | 11 | Hendricks | Burnes | | Winker |
| 5/4/2021 | | | SCA | 3 | SMC | 7 | Gonzales | Turnbull | | Riley |
| 5/4/2021 | | | CCC | 7 | SEA | 6 | Cisnero | Bard,D | Diaz,Ed | Rizzo |
| 5/4/2021 | | | ISO | 0 | ATK | 8 | Yarbrough | Kim | | Yastrzemski |
| 5/4/2021 | | | LTR | 3 | GOT | 4 | Baez,P | Lopez,P | Green | Grisham |
| 5/4/2021 | | | PHS | 4 | CYC | 5 | Norris | Pena | Pressly | Gyorko |
| 5/4/2021 | | | WHC | 2 | PLU | 10 | Davies | Sheffield | | Mejia,F |
| 5/4/2021 | | | JOT | 3 | BEA | 4 | Pomeranz | Morejon | Jansen,K | Wong |
| 5/4/2021 | | | COL | 1 | PAN | 11 | Duffy | Quintana | | |
| 5/4/2021 | | | LVB | 2 | PUR | 15 | Freeland | Teheran | | Severino |
| 5/5/2021 | | | JER | 13 | NUT | 2 | Roark | Javier | | Happ,I |
| 5/5/2021 | | | LAH | 19 | NHH | 11 | Smith,B | Allen,L | Ramirez,E | Ramirez,J |
| 5/5/2021 | | 15 | HOU | 2 | BOM | 3 | Tate | Foster | | Goldschmidt |
| 5/5/2021 | | | SCA | 12 | SMC | 8 | Romo | Ramirez,No | | Yelich |
| 5/5/2021 | | | CCC | 16 | SEA | 2 | Nola,Aa | Mahle | | Cruz,N |
| 5/5/2021 | | | ISO | 2 | ATK | 4 | Montgomery,J | Clevinger | Martin,C | Long |
| 5/5/2021 | | | LTR | 5 | GOT | 9 | Alzolay | Fiers | | Smith,Do |
| 5/5/2021 | | | PHS | 8 | CYC | 4 | Brubaker | Garrett,B | | Higashioka |
| 5/5/2021 | | | WHC | 10 | PLU | 1 | Holland,G | Glasnow | | Grandal |
| 5/5/2021 | | 10 | JOT | 8 | BEA | 10 | Rosenthal | Alcala | | Smith,WD |
| 5/5/2021 | | | COL | 4 | PAN | 0 | Peralta,F | Dunn | Gant | Adames |
| 5/5/2021 | | | LVB | 3 | PUR | 5 | Jeffress | Stratton | | Severino |
| 5/6/2021 | | | JER | 4 | NUT | 0 | Montas | Fedde | Iglesias,R | Reynolds,B |
| 5/6/2021 | | | LAH | 10 | NHH | 7 | Paredes,E | Quantrill | Hendriks | Taylor,C |
| 5/6/2021 | | | HOU | 6 | BOM | 4 | Gallen | Urias,J | Smith,R | McBroom |
| 5/6/2021 | | | SCA | 3 | SMC | 2 | Clippard | Matzek | Rogers,Ta | Bellinger |
| 5/6/2021 | | 10 | CCC | 3 | SEA | 4 | Hill,T | Diaz,Ed | | Ruiz,R |
| 5/6/2021 | | | ISO | 8 | ATK | 2 | Wainwright | Skubal | | Pederson |
| 5/6/2021 | | | LTR | 5 | GOT | 6 | Garrett,A | Webb,T | Green | Gregorius |
| 5/6/2021 | | | PHS | 2 | CYC | 5 | Heaney | Giolito | Pressly | Albies |
| 5/6/2021 | | | WHC | 9 | PLU | 5 | Suero | Garcia,B | | Ward |
| 5/6/2021 | | | JOT | 0 | BEA | 4 | Paddack | Flaherty | | Tejeda |
| 5/6/2021 | | | COL | 0 | PAN | 7 | Musgrove | Greinke | Heuer | Rosario,A |
| 5/6/2021 | | | LVB | 4 | PUR | 0 | Akin | Webb,L | Garcia,LH | |
| 5/8/2021 | | | NUT | 7 | JER | 9 | Britton | Perez,Ma | Iglesias,R | Perez,S |
| 5/8/2021 | | 10 | NHH | 5 | LAH | 6 | Hendriks | Smeltzer | | Turner,T |
| 5/8/2021 | | | BOM | 4 | HOU | 10 | Gausman | Houser | | Machado |
| 5/8/2021 | | | SMC | 5 | SCA | 0 | Anderson,I | Wright | | Riley |
| 5/8/2021 | | | SEA | 1 | CCC | 4 | Marquez,G | Fleming | Hand | Hernandez,Ce |
| 5/8/2021 | | | ATK | 7 | ISO | 2 | Tomlin | Cobb | | Markakis |
| 5/8/2021 | | | GOT | 2 | LTR | 7 | Peterson,D | Lester | | Soto,J |
| 5/8/2021 | | | CYC | 1 | PHS | 2 | Rainey | Almonte,Y | Anderson,N | Schwarber |
| 5/8/2021 | | | PLU | 5 | WHC | 4 | Garcia,Ja | Plesac | Garcia,B | |
| 5/8/2021 | | | BEA | 9 | JOT | 6 | Fry,P | Alcantara,Sa | Jansen,K | Smith,WD |
| 5/8/2021 | | | PAN | 2 | COL | 13 | Scherzer | Lopez,J | | |
| 5/8/2021 | | | PUR | 5 | LVB | 2 | Eshelman | Anderson,Ty | Jeffress | La Stella |
| 5/9/2021 | | | NUT | 6 | JER | 18 | Singer | Bauer | Gonzalez,V | Happ,I |
| 5/9/2021 | | | NHH | 2 | LAH | 1 | Brault | Garcia,D | Smeltzer | Guzman,R |
| 5/9/2021 | | 10 | BOM | 6 | HOU | 3 | Castillo,D | Smyly | Colome | LeMahieu |
| 5/9/2021 | | | SMC | 4 | SCA | 12 | Cole,G | Berrios | Clippard | Guerrero |
| 5/9/2021 | | | SEA | 6 | CCC | 5 | Bassitt | Lynn | Plutko | Ruiz,R |
| 5/9/2021 | | | ATK | 1 | ISO | 4 | Darvish | Fried | Antone | Freeman,F |
| 5/9/2021 | | | GOT | 5 | LTR | 3 | Gray,S | Eflin | Green | Smith,Do |
| 5/9/2021 | | | CYC | 5 | PHS | 8 | Cahill | Norris | | Joyce |
| 5/9/2021 | | | PLU | 5 | WHC | 0 | Gonsolin | Sheffield | | Marte,K |
| 5/9/2021 | | | BEA | 2 | JOT | 4 | Bieber | Bundy | Castro,M | Peralta,D |
| 5/9/2021 | | | PAN | 3 | COL | 4 | Lindblom | Matz | Gant | Adames |
| 5/9/2021 | | | PUR | 7 | LVB | 3 | Hudson,Dak | Castellani | | Severino |
| 5/10/2021 | | | NUT | 1 | JER | 3 | Valdez,F | Senzatela | Iglesias,R | Candelario |
| 5/10/2021 | | | NHH | 3 | LAH | 4 | Thielbar | Kolarek | | Voit |
| 5/10/2021 | | | BOM | 2 | HOU | 4 | Burnes | Hendricks | Hahn | Tatis |
| 5/10/2021 | | | SMC | 8 | SCA | 4 | Gonzales | Buttrey | Matzek | Riley |
| 5/10/2021 | | | SEA | 3 | CCC | 4 | Miller,A | Baragar | Hand | Rizzo |
| 5/10/2021 | | | ATK | 3 | ISO | 7 | Kim | Yarbrough | Andriese | |
| 5/10/2021 | | | GOT | 10 | LTR | 6 | Kershaw | Dobnak | | Kepler |
| 5/10/2021 | | | CYC | 6 | PHS | 7 | Merryweather | Pressly | | Solano |
| 5/10/2021 | | | PLU | 6 | WHC | 4 | Gibson | Voth | | Bregman |
| 5/10/2021 | | | BEA | 3 | JOT | 0 | Porcello | McCullers | Jansen,K | Cano |
| 5/10/2021 | | | PAN | 2 | COL | 6 | Peralta,F | Civale | Pagan | Turner,J |
| 5/10/2021 | | | PUR | 4 | LVB | 6 | Stratton | Staumont | | Kieboom |
| 5/11/2021 | | | LVB | 2 | JER | 19 | Roark | Stripling | | Perez,S |
| 5/11/2021 | | 10 | SCA | 10 | LAH | 7 | Montero | Hendriks | Cole,AJ | Bogaerts |
| 5/11/2021 | | | HOU | 5 | WHC | 1 | Lamet | Keller,B | | Tatis |
| 5/11/2021 | | | JOT | 1 | CCC | 3 | Nola,Aa | Bumgarner | Hand | Dalbec |
| 5/11/2021 | | | COL | 1 | ISO | 10 | Clevinger | Greinke | | Seager,C |
| 5/11/2021 | | 11 | PHS | 6 | LTR | 5 | Anderson,N | Zimmer,K | | Profar |
| 5/12/2021 | | | LVB | 1 | JER | 5 | Montas | Rogers,Tr | | |
| 5/12/2021 | | | SCA | 2 | LAH | 3 | Chapman,A | Stashak | | Ramirez,J |
| 5/12/2021 | | | HOU | 4 | WHC | 1 | Gallen | Plesac | Hahn | Tatis |
| 5/12/2021 | | 15 | JOT | 7 | CCC | 4 | Morejon | Richards,G | | Cronenworth |
| 5/12/2021 | | | COL | 0 | ISO | 5 | Wainwright | Kay | | Hernandez,En |
| 5/12/2021 | | | PHS | 10 | LTR | 4 | Giolito | Fiers | | Joyce |
| 5/13/2021 | | | LVB | 1 | JER | 8 | Junis | Anderson,Ty | | Semien |
| 5/13/2021 | | | SCA | 2 | LAH | 6 | Woodruff | Wright | Paredes,E | Merrifield |
| 5/13/2021 | | | HOU | 4 | WHC | 0 | Foster | Holland,G | | Machado |
| 5/13/2021 | | | JOT | 2 | CCC | 9 | Marquez,G | Alcantara,Sa | | Kiermaier |
| 5/13/2021 | | | COL | 5 | ISO | 10 | DeSclafani | Scherzer | Antone | Eaton |
| 5/13/2021 | | | PHS | 9 | LTR | 5 | Cueto | Curtiss | Kinley | Devers |
| 5/14/2021 | | | LVB | 7 | JER | 10 | Singer | Teheran | Iglesias,R | Happ,I |
| 5/14/2021 | | | SCA | 4 | LAH | 2 | Wacha | Keuchel | Rogers,Ta | Yelich |
| 5/14/2021 | | | HOU | 8 | WHC | 2 | Buehler | Voth | | Tucker,K |
| 5/14/2021 | | 11 | JOT | 2 | CCC | 4 | Mayers | James | | Realmuto |
| 5/14/2021 | | | COL | 4 | ISO | 7 | Darvish | Lindblom | Antone | Pederson |
| 5/14/2021 | | | PHS | 2 | LTR | 3 | Kikuchi | Guerra,Ju | Weems | Garcia,Av |
| 5/16/2021 | | | LAH | 0 | JER | 2 | Valdez,F | Castillo,L | | Reynolds,B |
| 5/16/2021 | | | HOU | 5 | LVB | 0 | Burnes | Cease | | Tatis |
| 5/16/2021 | | | SCA | 2 | JOT | 5 | McCullers | Turnbull | Morejon | Arraez |
| 5/16/2021 | | 10 | LTR | 8 | CCC | 7 | Bummer | Cisnero | Yates | France |
| 5/16/2021 | | | WHC | 1 | ISO | 5 | Kim | Keller,B | Antone | Choi |
| 5/16/2021 | | | COL | 3 | PHS | 5 | Shoemaker | Greinke | Anderson,N | Diaz,A |
| 5/17/2021 | | | LAH | 5 | JER | 7 | Roark | Keller,M | Iglesias,R | McMahon |
| 5/17/2021 | | | HOU | 9 | LVB | 4 | Lamet | Castellani | | Springer |
| 5/17/2021 | | 10 | SCA | 8 | JOT | 9 | Morejon | Stashak | | Diaz,Y |
| 5/17/2021 | | | LTR | 0 | CCC | 2 | Corbin | Dobnak | | Hernandez,Ce |
| 5/17/2021 | | | WHC | 3 | ISO | 2 | Plesac | Clevinger | Holland,G | Frazier,A |
| 5/17/2021 | | | COL | 4 | PHS | 5 | Kinley | Kay | Anderson,N | Haggerty |
| 5/18/2021 | | | LAH | 6 | JER | 10 | Rasmussen | Woodruff | Gonzalez,V | Acuna |
| 5/18/2021 | | | HOU | 9 | LVB | 3 | Gallen | Stripling | Foster | Machado |
| 5/18/2021 | | | SCA | 4 | JOT | 6 | Flaherty | Bubic | Morejon | Cabrera,A |
| 5/18/2021 | | | LTR | 0 | CCC | 7 | Nola,Aa | Eflin | | Ozuna |
| 5/18/2021 | | 10 | WHC | 4 | ISO | 5 | Antone | Holland,G | | Hilliard |
| 5/18/2021 | | | COL | 4 | PHS | 3 | Scherzer | Pena | Gant | Baez,J |
| 5/19/2021 | | | HOU | 11 | JER | 2 | Gausman | Junis | Smyly | Tucker,K |
| 5/19/2021 | | | LAH | 13 | JOT | 2 | Ramirez,E | Alcantara,Sa | | Gardner |
| 5/19/2021 | | | SCA | 14 | CCC | 12 | Cole,AJ | Ryu | Montero | Guerrero |
| 5/19/2021 | | | ISO | 12 | PHS | 15 | Rainey | Givens | | Devers |
| 5/19/2021 | | | COL | 2 | LTR | 10 | Lopez,P | Lindblom | | Olson |
| 5/19/2021 | | | LVB | 1 | WHC | 2 | Voth | Anderson,Ty | Suero | Frazier,A |
| 5/20/2021 | | 11 | HOU | 6 | JER | 9 | Gonzalez,V | Hahn | | Perez,S |
| 5/20/2021 | | 10 | LAH | 6 | JOT | 5 | Dolis | Castro,M | Hendriks | Voit |
| 5/20/2021 | | | SCA | 9 | CCC | 1 | Cole,G | Marquez,G | | Bellinger |
| 5/20/2021 | | | ISO | 7 | PHS | 2 | Darvish | Cahill | | Freeman,F |
| 5/20/2021 | | | COL | 9 | LTR | 12 | Duffey | Quintana | | Soto,J |
| 5/20/2021 | | | LVB | 2 | WHC | 9 | Gallegos | Rogers,Tr | | Pillar |
| 5/21/2021 | | | HOU | 2 | JER | 0 | Burnes | Valdez,F | Hahn | Gomes |
| 5/21/2021 | | | LAH | 6 | JOT | 2 | Dolis | Reyes,A | Chapman,A | Vazquez |
| 5/21/2021 | | | SCA | 4 | CCC | 7 | Lynn | Turnbull | Miller,A | Realmuto |
| 5/21/2021 | | | ISO | 4 | PHS | 1 | Kim | Shoemaker | Harvey,H | Contreras,WE |
| 5/21/2021 | | | COL | 7 | LTR | 8 | Zimmer,K | Newsome | | Ruiz,K |
| 5/21/2021 | | | LVB | 0 | WHC | 5 | Plesac | Cease | | Frazier,A |
| 5/22/2021 | | | SCA | 2 | JER | 5 | Roark | Boyd | Iglesias,R | Perez,S |
| 5/22/2021 | | | LAH | 9 | LVB | 2 | Garcia,D | Akin | | Ramirez,J |
| 5/22/2021 | | | HOU | 4 | ISO | 0 | Lamet | Clevinger | | Tatis |
| 5/22/2021 | | | CCC | 4 | PHS | 6 | Guerra,Ju | Richards,G | Anderson,N | Bryant |
| 5/22/2021 | | 11 | JOT | 3 | LTR | 4 | Curtiss | Cabrera,G | | Kemp,T |
| 5/22/2021 | | | COL | 7 | WHC | 3 | Peralta,F | Sheffield | | Baez,J |
| 5/23/2021 | | 10 | SCA | 2 | JER | 3 | Britton | Montero | | Happ,I |
| 5/23/2021 | | | LAH | 7 | LVB | 6 | Woodruff | Stripling | | Merrifield |
| 5/23/2021 | | | HOU | 9 | ISO | 6 | Gallen | Andriese | Minter | Machado |
| 5/23/2021 | | | CCC | 4 | PHS | 1 | Corbin | Giolito | Hand | Realmuto |
| 5/23/2021 | | | JOT | 6 | LTR | 1 | Flaherty | Peterson,D | | Cabrera,A |
| 5/23/2021 | | | COL | 8 | WHC | 4 | Scherzer | Voth | Newsome | Tsutsugo |
| 5/24/2021 | | | SCA | 1 | JER | 6 | Junis | Wright | | Verdugo |
| 5/24/2021 | | | LAH | 7 | LVB | 4 | Slegers | Garcia,LH | | Voit |
| 5/24/2021 | | | HOU | 2 | ISO | 6 | Cobb | Gausman | | Donaldson |
| 5/24/2021 | | | CCC | 4 | PHS | 0 | Nola,Aa | Cueto | Mayers | Cruz,N |
| 5/24/2021 | | | JOT | 5 | LTR | 6 | Eflin | Alcantara,Sa | Zimmer,K | |
| 5/24/2021 | | | COL | 2 | WHC | 4 | Keller,B | Lindblom | Sims | Frazier,A |
| 5/26/2021 | | | JER | 4 | HOU | 11 | Buehler | Singer | Smith,R | Buxton |
| 5/26/2021 | | | JOT | 10 | LAH | 4 | Bieber | May,D | | Moustakas |
| 5/26/2021 | | | CCC | 9 | SCA | 5 | Ryu | Cole,G | | Stewart,DJ |
| 5/26/2021 | | | PHS | 7 | ISO | 11 | Darvish | Cahill | | Donaldson |
| 5/26/2021 | | | LTR | 1 | COL | 6 | Greinke | Dobnak | Pagan | Akiyama |
| 5/26/2021 | | | WHC | 11 | LVB | 1 | Plesac | Castellani | | Moran,C |
| 5/27/2021 | | | JER | 3 | HOU | 1 | Valdez,F | Burnes | | Perez,S |
| 5/27/2021 | | 10 | JOT | 6 | LAH | 5 | Castro,M | Hendriks | | Bader |
| 5/27/2021 | | | CCC | 4 | SCA | 3 | Marquez,G | Turnbull | Richards,G | Rendon |
| 5/27/2021 | | | PHS | 3 | ISO | 0 | Rainey | Andriese | Anderson,N | Schwarber |
| 5/27/2021 | | | LTR | 5 | COL | 6 | Kay | Yates | | Mountcastle |
| 5/27/2021 | | | WHC | 5 | LVB | 3 | Gallegos | Anderson,Ty | Holland,G | |
| 5/28/2021 | | | JER | 4 | HOU | 2 | Roark | Lamet | Iglesias,R | Perez,S |
| 5/28/2021 | | | JOT | 1 | LAH | 6 | Woodruff | Bumgarner | | Voit |
| 5/28/2021 | | | CCC | 5 | SCA | 6 | Boyd | Lynn | Montero | Bellinger |
| 5/28/2021 | | | PHS | 1 | ISO | 3 | Clevinger | Brubaker | Antone | Freeman,F |
| 5/28/2021 | | | LTR | 6 | COL | 7 | Newsome | Webb,T | | Turner,J |
| 5/28/2021 | | 10 | WHC | 7 | LVB | 6 | Soto,G | Burdi,Z | Holland,G | O'Neill |
| 5/29/2021 | | | JER | 10 | SCA | 8 | Britton | Bubic | Gonzalez,V | Perez,S |
| 5/29/2021 | | | LVB | 0 | LAH | 6 | Castillo,L | Teheran | | Vazquez |
| 5/29/2021 | | | ISO | 1 | HOU | 13 | Gallen | Wainwright | Smyly | Machado |
| 5/29/2021 | | 19 | PHS | 5 | CCC | 6 | Reid-Foley | Kinley | | Rizzo |
| 5/29/2021 | | | LTR | 15 | JOT | 17 | Cabrera,G | Taylor,Bl | | Peralta,D |
| 5/29/2021 | | | WHC | 2 | COL | 0 | Keller,B | Pagan | | Moran,C |
| 5/30/2021 | | | JER | 5 | SCA | 6 | Montero | Hartlieb | | |
| 5/30/2021 | | | LVB | 5 | LAH | 10 | Smith,B | Rogers,Tr | Hendriks | Ramirez,J |
| 5/30/2021 | | | ISO | 2 | HOU | 6 | Gausman | Cobb | | Reyes,F |
| 5/30/2021 | | | PHS | 12 | CCC | 4 | Cueto | Corbin | | Devers |
| 5/30/2021 | | | LTR | 5 | JOT | 6 | Morejon | Weems | | Arozarena |
| 5/30/2021 | | | WHC | 5 | COL | 4 | Plesac | Newsome | Holland,G | Moran,C |
| 5/31/2021 | | | JER | 3 | SCA | 1 | Singer | Cole,G | Hartlieb | Happ,I |
| 5/31/2021 | | | LVB | 0 | LAH | 11 | May,D | Akin | Slegers | Taylor,C |
| 5/31/2021 | | | ISO | 3 | HOU | 4 | Foster | Antone | | Segura |
| 5/31/2021 | | | PHS | 11 | CCC | 2 | Cody | Nola,Aa | | Duvall |
| 5/31/2021 | | | LTR | 6 | JOT | 5 | Bummer | Alcala | Duffey | Soto,J |
| 5/31/2021 | | | WHC | 9 | COL | 1 | Sheffield | Greinke | Sims | Hoskins |
| 6/1/2021 | | | JER | 1 | LTR | 17 | Lopez,P | Valdez,F | | Rojas,M |
| 6/1/2021 | | | ISO | 0 | LAH | 3 | Keuchel | Kim | Perez,O | Ramirez,J |
| 6/1/2021 | | | JOT | 3 | HOU | 8 | Smith,R | McCullers | | Tatis |
| 6/1/2021 | | | COL | 2 | SCA | 9 | Turnbull | Peralta,F | | Alfaro |
| 6/1/2021 | | 10 | CCC | 5 | WHC | 6 | Holland,G | Miller,A | | Mendick |
| 6/1/2021 | | | LVB | 2 | PHS | 4 | Guerra,Ju | Teheran | | Devers |
| 6/2/2021 | | | JER | 4 | LTR | 8 | Fiers | Allard | | Garcia,Av |
| 6/2/2021 | | | ISO | 6 | LAH | 12 | Ramirez,E | Clevinger | | Merrifield |
| 6/2/2021 | | | JOT | 1 | HOU | 3 | Smyly | Bumgarner | Hahn | McBroom |
| 6/2/2021 | | | COL | 5 | SCA | 3 | Scherzer | Boyd | Quintana | Olivares |
| 6/2/2021 | | | CCC | 0 | WHC | 4 | Keller,B | Marquez,G | | O'Neill |
| 6/2/2021 | | | LVB | 1 | PHS | 5 | Brubaker | Castellani | | Devers |
| 6/3/2021 | | | JER | 0 | LTR | 1 | Eflin | Montas | Zimmer,K | Polanco,J |
| 6/3/2021 | | | ISO | 0 | LAH | 6 | Castillo,L | Wainwright | | Turner,T |
| 6/3/2021 | | | JOT | 3 | HOU | 5 | Smyly | James | | McBroom |
| 6/3/2021 | | | COL | 0 | SCA | 3 | Bubic | Lindblom | Montero | Muncy |
| 6/3/2021 | | | CCC | 0 | WHC | 4 | Plesac | Lynn | Sims | Galvis |
| 6/3/2021 | | | LVB | 1 | PHS | 9 | Giolito | Cease | Pena | Schwarber |
| 6/4/2021 | | | JER | 4 | LAH | 10 | Garcia,D | Junis | | Ramirez,J |
| 6/4/2021 | | | LVB | 5 | HOU | 10 | Gausman | Stripling | | Walker,C |
| 6/4/2021 | | | JOT | 2 | SCA | 8 | Wright | Alcantara,Sa | | Shaw,T |
| 6/4/2021 | | | CCC | 7 | LTR | 3 | Richards,G | Dobnak | | Stewart,DJ |
| 6/4/2021 | | | ISO | 1 | WHC | 7 | Sheffield | Cobb | | Flowers |
| 6/4/2021 | | | PHS | 6 | COL | 1 | Cueto | Newsome | | Joyce |
| 6/5/2021 | | 12 | JER | 0 | LAH | 4 | Chapman,A | Iglesias,R | | Voit |
| 6/5/2021 | | | LVB | 4 | HOU | 3 | Rogers,Tr | Buehler | Garcia,LH | |
| 6/5/2021 | | | JOT | 2 | SCA | 3 | Cole,AJ | Castro,M | | Santana,C |
| 6/5/2021 | | | CCC | 8 | LTR | 7 | Cisnero | Weems | Hand | Kiermaier |
| 6/5/2021 | | | ISO | 6 | WHC | 10 | Voth | Darvish | | Moran,C |
| 6/5/2021 | | | PHS | 8 | COL | 12 | Greinke | Cody | | Chavis |
| 6/6/2021 | | | JER | 4 | LAH | 2 | Valdez,F | Keuchel | Parker | Reynolds,B |
| 6/6/2021 | | | LVB | 1 | HOU | 6 | Burnes | Anderson,Ty | Armstrong | Springer |
| 6/6/2021 | | 10 | JOT | 6 | SCA | 5 | Reyes,A | Montero | James | Frazier,C |
| 6/6/2021 | | | CCC | 7 | LTR | 2 | Nola,Aa | Lopez,P | Hand | Kiermaier |
| 6/6/2021 | | 10 | ISO | 3 | WHC | 2 | Andriese | Holland,G | Antone | Freeman,F |
| 6/6/2021 | | | PHS | 11 | COL | 5 | Arrieta | Peralta,F | | Solano |
| 6/7/2021 | | 10 | JER | 1 | WHC | 2 | Hatch | Hartlieb | | |
| 6/7/2021 | | | CCC | 3 | LAH | 7 | Woodruff | Marquez,G | | Voit |
| 6/7/2021 | | | COL | 2 | HOU | 4 | Lamet | Scherzer | Hahn | Buxton |
| 6/7/2021 | | | LVB | 2 | SCA | 4 | Clippard | Castellani | Romo | Yelich |
| 6/7/2021 | | | ISO | 11 | LTR | 3 | Clevinger | Fiers | | Seager,C |
| 6/7/2021 | | | PHS | 6 | JOT | 7 | Alcala | Kinley | James | Anderson,Ti |
| 6/8/2021 | | | JER | 5 | WHC | 8 | Sheffield | Montas | | Frazier,A |
| 6/8/2021 | | 10 | CCC | 2 | LAH | 3 | Valdez,C | Lynn | | Cordero,F |
| 6/8/2021 | | | COL | 0 | HOU | 8 | Gallen | Lindblom | Smith,R | Tucker,K |
| 6/8/2021 | | | LVB | 5 | SCA | 3 | Cease | Bubic | Stratton | Jimenez,E |
| 6/8/2021 | | | ISO | 5 | LTR | 3 | Wainwright | Eflin | Antone | Stevenson |
| 6/8/2021 | | | PHS | 6 | JOT | 3 | Giolito | Flaherty | Anderson,N | Duvall |
| 6/9/2021 | | 11 | JER | 9 | WHC | 5 | Hartlieb | Holland,G | | Hoerner |
| 6/9/2021 | | | CCC | 8 | LAH | 3 | Ryu | May,D | | Cruz,N |
| 6/9/2021 | | | COL | 1 | HOU | 4 | Gausman | Quintana | Hahn | Tatis |
| 6/9/2021 | | | LVB | 3 | SCA | 1 | Stripling | Cole,AJ | Garcia,LH | Pujols |
| 6/9/2021 | | 10 | ISO | 10 | LTR | 6 | Antone | Wisler | | Eaton |
| 6/9/2021 | | | PHS | 5 | JOT | 2 | Cueto | Alcantara,Sa | Rainey | Devers |
| 6/11/2021 | | | LTR | 11 | JER | 5 | Curtiss | Rasmussen | | Hicks |
| 6/11/2021 | | 11 | LAH | 6 | ISO | 1 | Perez,O | Harvey,H | | Taylor,C |
| 6/11/2021 | | | HOU | 2 | JOT | 9 | Bieber | Buehler | Alcala | Anderson,Ti |
| 6/11/2021 | | | SCA | 3 | COL | 4 | Peralta,F | Montero | | Kirk |
| 6/11/2021 | | | WHC | 0 | CCC | 2 | Corbin | Keller,B | Hand | Rizzo |
| 6/11/2021 | | | PHS | 4 | LVB | 1 | Cody | Teheran | Rainey | Schwarber |
| 6/12/2021 | | | LTR | 12 | JER | 4 | Kikuchi | Valdez,F | | Tellez |
| 6/12/2021 | | | LAH | 3 | ISO | 8 | Kim | Woodruff | | Donaldson |
| 6/12/2021 | | | HOU | 1 | JOT | 5 | McCullers | Burnes | | Arraez |
| 6/12/2021 | | | SCA | 2 | COL | 3 | Scherzer | Cole,AJ | Peralta,F | Akiyama |
| 6/12/2021 | | 15 | WHC | 5 | CCC | 2 | Hatch | Diaz,Ed | | Moran,C |
| 6/12/2021 | | | PHS | 9 | LVB | 5 | Pena | Anderson,Ty | | Fuentes |
| 6/13/2021 | | | LTR | 7 | JER | 5 | Peterson,D | Allard | Zimmer,K | Rojas,M |
| 6/13/2021 | | | LAH | 7 | ISO | 1 | Keuchel | Andriese | Hendriks | Nimmo |
| 6/13/2021 | | | HOU | 17 | JOT | 1 | Lamet | Bumgarner | | McBroom |
| 6/13/2021 | | | SCA | 6 | COL | 2 | Buttrey | Lindblom | Cole,AJ | Bellinger |
| 6/13/2021 | | | WHC | 2 | CCC | 5 | Marquez,G | Sheffield | | Realmuto |
| 6/13/2021 | | | PHS | 14 | LVB | 4 | Brubaker | Cease | | Miller,B |
| 6/14/2021 | | | LTR | 15 | JER | 9 | Weems | Montas | | Kemp,T |
| 6/14/2021 | | | LAH | 3 | ISO | 7 | Wainwright | Castillo,L | Andriese | Donaldson |
| 6/14/2021 | | | HOU | 4 | JOT | 6 | Cabrera,G | Gallen | Castro,M | Moustakas |
| 6/14/2021 | | | SCA | 13 | COL | 2 | Bubic | Peralta,F | | Bogaerts |
| 6/14/2021 | | | WHC | 2 | CCC | 4 | Lynn | Soto,G | Cisnero | Rizzo |
| 6/14/2021 | | | PHS | 2 | LVB | 4 | Garcia,LH | Rainey | | Jimenez,E |
| 6/15/2021 | | | JER | 5 | CYC | 1 | Junis | Norris | Iglesias,R | Semien |
| 6/15/2021 | | | LAH | 1 | ATK | 2 | Tomlin | Garcia,D | Webb,J | McCann |
| 6/15/2021 | | | HOU | 6 | BEA | 1 | Gausman | Sanchez,An | Armstrong | Madrigal |
| 6/15/2021 | | | SCA | 6 | PAN | 3 | Wright | Musgrove | Montero | Shaw,T |
| 6/15/2021 | | | CCC | 5 | BOM | 1 | Nola,Aa | Houser | Miller,A | Kemp,M |
| 6/15/2021 | | | ISO | 7 | SMC | 0 | Cobb | Anderson,I | | Freeman,F |
| 6/15/2021 | | | LTR | 5 | NUT | 3 | Fiers | Perez,Ma | Garcia,Y | |
| 6/15/2021 | | | PHS | 9 | PUR | 2 | Cueto | Eshelman | Winkler | Miller,B |
| 6/15/2021 | | | WHC | 4 | SEA | 9 | Kintzler | Sims | | Hosmer |
| 6/15/2021 | | | LVB | 6 | GOT | 7 | Baez,P | Stripling | Barlow | Pinder |
| 6/15/2021 | | | JOT | 3 | PLU | 4 | Zuber | Holland,D | | Marte,K |
| 6/15/2021 | | | COL | 5 | NHH | 7 | Allen,L | Chatwood | | Conforto |
| 6/16/2021 | | | JER | 4 | CYC | 2 | Singer | Heaney | Iglesias,R | Semien |
| 6/16/2021 | | 15 | LAH | 9 | ATK | 5 | Valdez,C | Lorenzen | | Swanson,D |
| 6/16/2021 | | | HOU | 2 | BEA | 5 | Bundy | Marshall | Jansen,K | Judge |
| 6/16/2021 | | | SCA | 2 | PAN | 0 | Cole,G | Lopez,J | Montero | Shaw,T |
| 6/16/2021 | | | CCC | 2 | BOM | 4 | deGrom | Ryu | | Story |
| 6/16/2021 | | | ISO | 1 | SMC | 4 | Berrios | Darvish | Melancon | Riley |
| 6/16/2021 | | | LTR | 5 | NUT | 3 | Dobnak | Fairbanks | Webb,T | |
| 6/16/2021 | | | PHS | 8 | PUR | 5 | Merryweather | Staumont | | Devers |
| 6/16/2021 | | | WHC | 5 | SEA | 6 | Hill,T | Hatch | | Arcia |
| 6/16/2021 | | | LVB | 0 | GOT | 1 | Gray,S | Castellani | | |
| 6/16/2021 | | | JOT | 2 | PLU | 1 | Bieber | Sanchez,S | Castro,M | Stanton |
| 6/16/2021 | | | COL | 3 | NHH | 2 | Greinke | Brault | Gant | Adames |
| 6/17/2021 | | | JER | 3 | CYC | 9 | Means | Valdez,F | | Cabrera,M |
| 6/17/2021 | | | LAH | 5 | ATK | 3 | Woodruff | Yarbrough | Valdez,C | |
| 6/17/2021 | | | HOU | 13 | BEA | 8 | Foster | Jansen,K | | Reyes,F |
| 6/17/2021 | | | SCA | 11 | PAN | 0 | Turnbull | Matz | | Shaw,T |
| 6/17/2021 | | | CCC | 4 | BOM | 6 | Hendricks | Corbin | Colome | Dickerson,A |
| 6/17/2021 | | | ISO | 3 | SMC | 2 | Shreve | Melancon | Antone | Hilliard |
| 6/17/2021 | | | LTR | 13 | NUT | 7 | Wisler | Neris | | Olson |
| 6/17/2021 | | | PHS | 13 | PUR | 2 | Arrieta | Freeland | | Solano |
| 6/17/2021 | | | WHC | 9 | SEA | 1 | Sheffield | Snell | Hatch | Pillar |
| 6/17/2021 | | | LVB | 4 | GOT | 16 | Kershaw | Anderson,Ty | Smith,C | Grisham |
| 6/17/2021 | | | JOT | 9 | PLU | 6 | Reyes,A | Garcia,Ja | Morejon | Cronenworth |
| 6/17/2021 | | | COL | 3 | NHH | 4 | Quantrill | Lindblom | | Guzman,R |
| 6/18/2021 | | | CYC | 6 | JER | 12 | Rasmussen | Gonzalez,G | | Semien |
| 6/18/2021 | | | ATK | 4 | LAH | 8 | Keuchel | Montgomery,J | | Voit |
| 6/18/2021 | | | BEA | 5 | HOU | 6 | Smyly | Velasquez | Hahn | Walker,C |
| 6/18/2021 | | | PAN | 4 | SCA | 2 | Heuer | Montero | | Bart |
| 6/18/2021 | | 12 | BOM | 5 | CCC | 4 | Tate | Cisnero | | Brosseau |
| 6/18/2021 | | | SMC | 1 | ISO | 4 | DeSclafani | Walker,T | Antone | Freeman,F |
| 6/18/2021 | | 10 | NUT | 7 | LTR | 6 | Dayton | Yates | Marquez,B | Gallo |
| 6/18/2021 | | | PUR | 6 | PHS | 2 | Canning | Brubaker | Young,Al | Davis,JD |
| 6/18/2021 | | | SEA | 4 | WHC | 3 | Mahle | Voth | Bard,D | Encarnacion |
| 6/18/2021 | | 10 | GOT | 4 | LVB | 3 | Green | Garcia,LH | Barlow | Engel |
| 6/18/2021 | | | PLU | 3 | JOT | 11 | Bumgarner | Gibson | | Bell |
| 6/18/2021 | | | NHH | 5 | COL | 4 | Smeltzer | Pagan | Quantrill | Hays |
| 6/19/2021 | | | CYC | 9 | JER | 6 | Almonte,Y | Montas | | Bemboom |
| 6/19/2021 | | | ATK | 3 | LAH | 4 | Castillo,L | Treinen | Paredes,E | Taylor,C |
| 6/19/2021 | | | BEA | 3 | HOU | 9 | Gallen | Paddack | | Seager,K |
| 6/19/2021 | | | PAN | 5 | SCA | 11 | Bubic | Duffy | | Santana,C |
| 6/19/2021 | | | BOM | 10 | CCC | 4 | Urias,J | Lynn | | Goldschmidt |
| 6/19/2021 | | | SMC | 12 | ISO | 7 | Lugo,S | Wainwright | | Abreu,J |
| 6/19/2021 | | | NUT | 8 | LTR | 3 | Fedde | Peterson,D | | Romine,Au |
| 6/19/2021 | | | PUR | 7 | PHS | 4 | Scrubb | Giolito | Jeffress | Crawford,B |
| 6/19/2021 | | 15 | SEA | 4 | WHC | 5 | Suero | Hill,R | | Espinal |
| 6/19/2021 | | | GOT | 6 | LVB | 7 | Stephenson,R | Baez,P | | Huff |
| 6/19/2021 | | 13 | PLU | 0 | JOT | 1 | Morejon | Scott | | Stanton |
| 6/19/2021 | | | NHH | 0 | COL | 8 | Gant | Gray,J | | Akiyama |
| 6/20/2021 | | | CYC | 8 | JER | 10 | Maton | Strahm | Iglesias,R | Verdugo |
| 6/20/2021 | | | ATK | 2 | LAH | 9 | Garcia,D | Tomlin | | Ramirez,J |
| 6/20/2021 | | | BEA | 2 | HOU | 16 | Gausman | Sanchez,An | Smith,R | Tucker,K |
| 6/20/2021 | | | PAN | 0 | SCA | 6 | Wright | Dunn | | Yelich |
| 6/20/2021 | | | BOM | 1 | CCC | 3 | Diaz,Ed | Castillo,D | | Stewart,DJ |
| 6/20/2021 | | | SMC | 17 | ISO | 10 | Anderson,I | Cobb | | Grossman |
| 6/20/2021 | | | NUT | 0 | LTR | 2 | Lopez,P | Perez,Ma | Webb,T | Rojas,M |
| 6/20/2021 | | 12 | PUR | 3 | PHS | 2 | Jeffress | Kinley | Valdez,P | La Stella |
| 6/20/2021 | | | SEA | 2 | WHC | 3 | Plesac | Fleming | Holland,G | Espinal |
| 6/20/2021 | | | GOT | 8 | LVB | 3 | Lester | Akin | | Edman |
| 6/20/2021 | | | PLU | 0 | JOT | 1 | Alcantara,Sa | Glasnow | Reyes,A | Ramos,W |
| 6/20/2021 | | | NHH | 12 | COL | 3 | Ynoa | Newsome | | Guzman,R |
| 6/21/2021 | | | JER | 6 | LAH | 3 | Singer | May,D | Iglesias,R | Acuna |
| 6/21/2021 | | | LVB | 3 | HOU | 10 | Buehler | Castellani | | Tatis |
| 6/21/2021 | | | JOT | 3 | SCA | 9 | Cole,AJ | Cabrera,G | Montero | Bogaerts |
| 6/21/2021 | | | CCC | 5 | LTR | 1 | Ryu | Fiers | | Lindor |
| 6/21/2021 | | | ISO | 7 | WHC | 0 | Darvish | Sheffield | | Pederson |
| 6/21/2021 | | | PHS | 2 | COL | 3 | Greinke | Cody | Pagan | Escobar |
| 6/22/2021 | | 10 | JER | 7 | LAH | 5 | Rasmussen | Hendriks | O'Day | Happ,I |
| 6/22/2021 | | | LVB | 1 | HOU | 2 | Hahn | Stratton | | Hayes |
| 6/22/2021 | | | JOT | 4 | SCA | 6 | Turnbull | McCullers | Romo | Muncy |
| 6/22/2021 | | | CCC | 2 | LTR | 8 | Eflin | Richards,G | | Garcia,LV |
| 6/22/2021 | | | ISO | 1 | WHC | 3 | Voth | Kim | Sims | Grandal |
| 6/22/2021 | | | PHS | 6 | COL | 4 | Arrieta | Scherzer | Hernandez,D | Profar |
| 6/23/2021 | | 11 | JER | 7 | LAH | 6 | O'Day | Perez,O | Hartlieb | |
| 6/23/2021 | | | LVB | 0 | HOU | 3 | Lamet | Cease | Hahn | Buxton |
| 6/23/2021 | | | JOT | 3 | SCA | 4 | Boyd | Bumgarner | Montero | Santana,C |
| 6/23/2021 | | | CCC | 7 | LTR | 11 | Zimmer,K | Marquez,G | | Olson |
| 6/23/2021 | | | ISO | 2 | WHC | 8 | Keller,B | Clevinger | | Frazier,A |
| 6/23/2021 | | | PHS | 12 | COL | 9 | Shoemaker | Lindblom | | Duvall |
| 6/25/2021 | | | LAH | 12 | JER | 6 | Castillo,L | Montas | | Nimmo |
| 6/25/2021 | | | HOU | 14 | LVB | 3 | Gallen | Stripling | | Tucker,K |
| 6/25/2021 | | | SCA | 3 | JOT | 6 | Flaherty | Bubic | | Bader |
| 6/25/2021 | | 10 | LTR | 2 | CCC | 3 | Hand | Taylor,Bl | | Ozuna |
| 6/25/2021 | | | WHC | 6 | ISO | 0 | Plesac | Wainwright | | Galvis |
| 6/25/2021 | | 11 | COL | 4 | PHS | 3 | Newsome | Winkler | | Baez,J |
| 6/26/2021 | | | LAH | 6 | JER | 2 | Slegers | Junis | | Ramirez,J |
| 6/26/2021 | | | HOU | 8 | LVB | 3 | Gausman | Teheran | Armstrong | Machado |
| 6/26/2021 | | | SCA | 3 | JOT | 4 | Alcantara,Sa | Wright | Reyes,A | Stanton |
| 6/26/2021 | | | LTR | 7 | CCC | 9 | Hand | Taylor,Bl | | Stewart,DJ |
| 6/26/2021 | | | WHC | 1 | ISO | 2 | Cobb | Sheffield | Antone | Seager,C |
| 6/26/2021 | | 10 | COL | 6 | PHS | 1 | Kay | Merryweather | | Tsutsugo |
| 6/27/2021 | | | LAH | 4 | JER | 3 | Keuchel | Singer | Hendriks | Knapp |
| 6/27/2021 | | 10 | HOU | 8 | LVB | 5 | Minter | Stratton | Hahn | Taylor,M |
| 6/27/2021 | | | SCA | 1 | JOT | 0 | Cole,G | Reyes,A | Montero | Alfaro |
| 6/27/2021 | | 10 | LTR | 4 | CCC | 2 | Webb,T | Cisnero | Duffey | Soto,J |
| 6/27/2021 | | | WHC | 6 | ISO | 7 | Darvish | Voth | Antone | Guillorme |
| 6/27/2021 | | | COL | 4 | PHS | 5 | Pena | Scherzer | Rainey | Diaz,A |
| 6/28/2021 | | | WHC | 6 | JER | 16 | Rasmussen | Keller,B | | |
| 6/28/2021 | | | LAH | 6 | CCC | 4 | Paredes,E | Diaz,Ed | Hendriks | Nimmo |
| 6/28/2021 | | | HOU | 7 | COL | 3 | Burnes | Lindblom | Smyly | Reyes,F |
| 6/28/2021 | | | SCA | 5 | LVB | 1 | Turnbull | Cease | | Heyward |
| 6/28/2021 | | | LTR | 4 | ISO | 3 | Lopez,P | Andriese | Taylor,Bl | Soto,J |
| 6/28/2021 | | | JOT | 5 | PHS | 1 | McCullers | Arrieta | | Anderson,Ti |
| 6/29/2021 | | | WHC | 8 | JER | 4 | Plesac | Allard | | Espinal |
| 6/29/2021 | | | LAH | 2 | CCC | 6 | Richards,G | May,D | | Lindor |
| 6/29/2021 | | | HOU | 10 | COL | 0 | Lamet | Chatwood | Smith,R | Segura |
| 6/29/2021 | | | SCA | 6 | LVB | 0 | Boyd | Anderson,Ty | | Bellinger |
| 6/29/2021 | | | LTR | 5 | ISO | 9 | DeSclafani | Fiers | Shreve | Seager,C |
| 6/29/2021 | | | JOT | 6 | PHS | 7 | Rainey | Alcala | Anderson,N | Miller,B |
| 6/30/2021 | | | WHC | 4 | JER | 15 | Britton | Sheffield | | Crawford,JP |
| 6/30/2021 | | | LAH | 7 | CCC | 3 | Castillo,L | Marquez,G | Ramirez,E | Ramirez,J |
| 6/30/2021 | | | HOU | 3 | COL | 4 | Gant | Hahn | | Canha |
| 6/30/2021 | | | SCA | 13 | LVB | 4 | Bubic | Stripling | | Heyward |
| 6/30/2021 | | | LTR | 4 | ISO | 7 | Wainwright | Eflin | Andriese | Freeman,F |
| 6/30/2021 | | | JOT | 2 | PHS | 3 | Kinley | James | Anderson,N | Berti |
| 7/1/2021 | | | COL | 2 | JER | 15 | Junis | Greinke | | Alonso |
| 7/1/2021 | | | LAH | 5 | LVB | 1 | Garcia,D | Castellani | | Ramirez,J |
| 7/1/2021 | | | HOU | 3 | ISO | 4 | DeSclafani | Gausman | Antone | Guillorme |
| 7/1/2021 | | | SCA | 11 | WHC | 1 | Wright | Voth | | Heyward |
| 7/1/2021 | | | PHS | 5 | CCC | 3 | Cueto | Lynn | Winkler | Duvall |
| 7/1/2021 | | | LTR | 7 | JOT | 6 | Webb,T | Castro,M | Bummer | Polanco,J |
| 7/2/2021 | | | COL | 2 | JER | 5 | O'Day | Scherzer | Iglesias,R | |
| 7/2/2021 | | | LAH | 7 | LVB | 2 | Keuchel | Akin | | Taylor,C |
| 7/2/2021 | | | HOU | 2 | ISO | 5 | Darvish | Buehler | Antone | Choi |
| 7/2/2021 | | | SCA | 1 | WHC | 2 | Keller,B | Cole,G | Suero | Galvis |
| 7/2/2021 | | | PHS | 13 | CCC | 3 | Cody | Corbin | | Higashioka |
| 7/2/2021 | | | LTR | 6 | JOT | 13 | Holland,D | Curtiss | | Bell |
| 7/3/2021 | | | COL | 1 | JER | 3 | Valdez,F | Pagan | Iglesias,R | Perez,S |
| 7/3/2021 | | | LAH | 6 | LVB | 2 | Woodruff | Cease | | Merrifield |
| 7/3/2021 | | | HOU | 5 | ISO | 1 | Marshall | Kim | Smyly | Tucker,K |
| 7/3/2021 | | | SCA | 0 | WHC | 3 | Plesac | Cole,AJ | | Hoskins |
| 7/3/2021 | | | PHS | 6 | CCC | 4 | Guerra,Ju | Nola,Aa | Anderson,N | |
| 7/3/2021 | | | LTR | 4 | JOT | 6 | McCullers | Kikuchi | Holland,D | Peralta,D |
| 7/4/2021 | | | JOT | 6 | JER | 14 | Gonzalez,V | Alcala | Iglesias,R | Happ,I |
| 7/4/2021 | | | LAH | 4 | HOU | 3 | May,D | Lamet | Hendriks | Merrifield |
| 7/4/2021 | | | LTR | 10 | SCA | 5 | Fiers | Boyd | | Polanco,J |
| 7/4/2021 | | | COL | 6 | CCC | 10 | Ryu | Kay | | Rizzo |
| 7/4/2021 | | | ISO | 5 | LVB | 4 | Andriese | Anderson,Ty | Antone | Donaldson |
| 7/4/2021 | | | WHC | 1 | PHS | 2 | Brubaker | Sheffield | Winkler | Duvall |
| 7/5/2021 | | | JOT | 11 | JER | 7 | Reyes,A | Montas | Morejon | Peralta,D |
| 7/5/2021 | | | LAH | 5 | HOU | 8 | Gallen | Castillo,L | | Tatis |
| 7/5/2021 | | | LTR | 1 | SCA | 2 | Cole,AJ | Lopez,P | Montero | Shaw,T |
| 7/5/2021 | | | COL | 0 | CCC | 2 | Richards,G | Peralta,F | Hand | Hernandez,Ce |
| 7/5/2021 | | | ISO | 5 | LVB | 2 | Wainwright | Teheran | Antone | Choi |
| 7/5/2021 | | 11 | WHC | 2 | PHS | 3 | Kinley | Soto,G | | Mondesi |
| 7/6/2021 | | | JOT | 3 | JER | 4 | Maton | Castro,M | | Candelario |
| 7/6/2021 | | 13 | LAH | 8 | HOU | 7 | Hendriks | Foster | | Meadows |
| 7/6/2021 | | | LTR | 10 | SCA | 7 | Peterson,D | Wright | | Soto,J |
| 7/6/2021 | | | COL | 4 | CCC | 5 | Hand | Pagan | | Ozuna |
| 7/6/2021 | | | ISO | 12 | LVB | 2 | Shreve | Rogers,Tr | | |
| 7/6/2021 | | | WHC | 3 | PHS | 5 | Cueto | Keller,B | Hernandez,D | Higashioka |
| 7/7/2021 | | | SCA | 2 | JER | 5 | Singer | Wacha | Iglesias,R | Acuna |
| 7/7/2021 | | 10 | LAH | 2 | PHS | 3 | Merryweather | Slegers | | Higashioka |
| 7/7/2021 | | | LTR | 5 | HOU | 8 | Buehler | Dobnak | Minter | Springer |
| 7/7/2021 | | | CCC | 9 | LVB | 4 | Lynn | Castellani | | Stewart,DJ |
| 7/7/2021 | | | JOT | 3 | ISO | 5 | Darvish | Bieber | Antone | Seager,C |
| 7/7/2021 | | | COL | 4 | WHC | 1 | Scherzer | Plesac | Gant | Tsutsugo |
| 7/8/2021 | | | SCA | 3 | JER | 5 | Valdez,F | Turnbull | O'Day | Happ,I |
| 7/8/2021 | | | LAH | 7 | PHS | 8 | Arrieta | Woodruff | Anderson,N | Duvall |
| 7/8/2021 | | | LTR | 0 | HOU | 2 | Burnes | Eflin | Smyly | Tatis |
| 7/8/2021 | | | CCC | 7 | LVB | 4 | Corbin | Stripling | Hand | Hernandez,Ce |
| 7/8/2021 | | | JOT | 3 | ISO | 7 | Kim | McCullers | | Seager,C |
| 7/8/2021 | | | COL | 3 | WHC | 4 | Hatch | Pagan | | Frazier,A |
| 7/9/2021 | | | SCA | 11 | JER | 8 | Cole,AJ | Gonzalez,V | Montero | Guerrero |
| 7/9/2021 | | | LAH | 9 | PHS | 2 | May,D | Shoemaker | | Dubon |
| 7/9/2021 | | | LTR | 3 | HOU | 9 | Marshall | Fiers | Smith,R | Segura |
| 7/9/2021 | | | CCC | 7 | LVB | 2 | Nola,Aa | Cease | | Realmuto |
| 7/9/2021 | | | JOT | 6 | ISO | 2 | Bumgarner | Clevinger | | Ramos,W |
| 7/9/2021 | | | COL | 1 | WHC | 6 | Voth | Kay | | Hoskins |
| 7/14/2021 | | | JER | 8 | LTR | 4 | Gonzalez,V | Webb,T | | Verdugo |
| 7/14/2021 | | | ISO | 9 | LAH | 8 | Andriese | Hendriks | Antone | Freeman,F |
| 7/14/2021 | | | JOT | 2 | HOU | 6 | Gallen | Flaherty | Hahn | Seager,K |
| 7/14/2021 | | 10 | COL | 3 | SCA | 2 | Peralta,F | Montero | | Tsutsugo |
| 7/14/2021 | | | CCC | 6 | WHC | 0 | Ryu | Keller,B | Reid-Foley | Hernandez,Ce |
| 7/14/2021 | | | LVB | 8 | PHS | 7 | Anderson,Ty | Giolito | Garcia,LH | Jimenez,E |
| 7/15/2021 | | | JER | 1 | LTR | 12 | Peterson,D | Weaver | | Vogelbach |
| 7/15/2021 | | | ISO | 3 | LAH | 8 | Woodruff | Cobb | Ramirez,E | Castro,W |
| 7/15/2021 | | | JOT | 1 | HOU | 0 | Alcantara,Sa | Gausman | | Villar |
| 7/15/2021 | | | COL | 3 | SCA | 7 | Wright | Scherzer | | Guerrero |
| 7/15/2021 | | | CCC | 3 | WHC | 1 | Marquez,G | Plesac | Hand | Altuve |
| 7/15/2021 | | | LVB | 5 | PHS | 7 | Rainey | Stratton | Anderson,N | Berti |
| 7/16/2021 | | | JER | 10 | LTR | 5 | Singer | Kikuchi | | Crawford,JP |
| 7/16/2021 | | | ISO | 3 | LAH | 5 | Keuchel | Darvish | Hendriks | Turner,T |
| 7/16/2021 | | | JOT | 6 | HOU | 3 | Bieber | Buehler | | Peralta,D |
| 7/16/2021 | | | COL | 4 | SCA | 1 | Lindblom | Cole,G | Peralta,F | Sanchez,G |
| 7/16/2021 | | | CCC | 6 | WHC | 1 | Lynn | Sheffield | | Ozuna |
| 7/16/2021 | | | LVB | 0 | PHS | 17 | Cody | Castellani | Merryweather | Diaz,A |
| 7/17/2021 | | | JER | 5 | LTR | 10 | Eflin | Valdez,F | | Tellez |
| 7/17/2021 | | | ISO | 9 | LAH | 2 | Kim | Garcia,D | | Guillorme |
| 7/17/2021 | | | JOT | 4 | HOU | 10 | Foster | Cabrera,G | | Machado |
| 7/17/2021 | | | COL | 7 | SCA | 8 | Romo | Newsome | Montero | Pollock |
| 7/17/2021 | | | CCC | 7 | WHC | 3 | Cisnero | Voth | | Dalbec |
| 7/17/2021 | | | LVB | 6 | PHS | 7 | Hernandez,D | Garcia,LH | Anderson,N | |
| 7/18/2021 | | | JER | 15 | COL | 8 | Parker | Quintana | | Reynolds,B |
| 7/18/2021 | | | LVB | 2 | LAH | 9 | Houck | Stripling | | Vazquez |
| 7/18/2021 | | 10 | ISO | 5 | HOU | 3 | Antone | Armstrong | | Pederson |
| 7/18/2021 | | | WHC | 1 | SCA | 3 | Boyd | Keller,B | Romo | Heyward |
| 7/18/2021 | | | CCC | 1 | PHS | 2 | Hernandez,D | Hand | | Duvall |
| 7/18/2021 | | | JOT | 0 | LTR | 9 | Webb,T | Bumgarner | | Maybin |
| 7/19/2021 | | | JER | 5 | COL | 7 | Greinke | O'Day | Gant | Mountcastle |
| 7/19/2021 | | 10 | LVB | 5 | LAH | 6 | Hendriks | Garcia,LH | | Cordero,F |
| 7/19/2021 | | | ISO | 3 | HOU | 7 | Gallen | Wainwright | | Machado |
| 7/19/2021 | | | WHC | 4 | SCA | 0 | Plesac | Bubic | Hatch | Frazier,A |
| 7/19/2021 | | | CCC | 11 | PHS | 6 | Ryu | Giolito | | Altuve |
| 7/19/2021 | | | JOT | 5 | LTR | 6 | Zimmer,K | Alcala | Webb,T | Hicks |
| 7/20/2021 | | | JER | 5 | COL | 10 | Scherzer | Junis | | Adames |
| 7/20/2021 | | | LVB | 1 | LAH | 10 | Woodruff | Anderson,Ty | | Ramirez,J |
| 7/20/2021 | | | ISO | 4 | HOU | 12 | Gausman | Cobb | | Tucker,K |
| 7/20/2021 | | | WHC | 2 | SCA | 6 | Wright | Sheffield | Montero | Guerrero |
| 7/20/2021 | | | CCC | 8 | PHS | 4 | Corbin | Cueto | | Ozuna |
| 7/20/2021 | | | JOT | 7 | LTR | 4 | Alcantara,Sa | Fiers | Castro,M | Peralta,D |
| 7/22/2021 | | | LTR | 3 | JER | 4 | Singer | Lopez,P | Iglesias,R | Crawford,JP |
| 7/22/2021 | | | LAH | 6 | ISO | 12 | Darvish | May,D | | Freeman,F |
| 7/22/2021 | | | HOU | 5 | JOT | 3 | Foster | Cabrera,G | Marshall | |
| 7/22/2021 | | | SCA | 3 | COL | 6 | Lindblom | Cole,G | Peralta,F | Akiyama |
| 7/22/2021 | | | WHC | 0 | CCC | 3 | Marquez,G | Voth | | Rendon |
| 7/22/2021 | | | PHS | 7 | LVB | 12 | Teheran | Cody | | Pujols |
| 7/23/2021 | | | LTR | 4 | JER | 5 | Iglesias,R | Webb,T | | Candelario |
| 7/23/2021 | | | LAH | 3 | ISO | 5 | Kim | Keuchel | | Correa |
| 7/23/2021 | | 10 | HOU | 7 | JOT | 8 | Castro,M | Marshall | | |
| 7/23/2021 | | | SCA | 10 | COL | 8 | Stashak | Newsome | Montero | Yelich |
| 7/23/2021 | | 12 | WHC | 0 | CCC | 1 | Cisnero | Holland,G | | Ozuna |
| 7/23/2021 | | | PHS | 23 | LVB | 12 | Kinley | Akin | Hernandez,D | Haggerty |
| 7/24/2021 | | | LTR | 4 | JER | 3 | Zimmer,K | Parker | Yates | Polanco,J |
| 7/24/2021 | | | LAH | 7 | ISO | 12 | Clevinger | Keller,M | | Freeman,F |
| 7/24/2021 | | | HOU | 6 | JOT | 3 | Lamet | Bumgarner | Hahn | McBroom |
| 7/24/2021 | | 13 | SCA | 6 | COL | 4 | Stashak | Quintana | Rogers,Ta | Shaw,T |
| 7/24/2021 | | 10 | WHC | 6 | CCC | 10 | Diaz,Ed | Sims | | Rizzo |
| 7/24/2021 | | | PHS | 15 | LVB | 4 | Anderson,N | Stripling | | Devers |
| 7/26/2021 | | | JER | 4 | JOT | 14 | Flaherty | Montas | Holland,D | Villar |
| 7/26/2021 | | | HOU | 7 | LAH | 6 | Smith,R | Dolis | Hahn | Gomes |
| 7/26/2021 | | | SCA | 2 | LTR | 5 | Eflin | Bubic | Duffey | Rios,E |
| 7/26/2021 | | 10 | CCC | 1 | COL | 2 | Newsome | Miller,A | | Mountcastle |
| 7/26/2021 | | | LVB | 6 | ISO | 20 | Wainwright | Garcia,LH | | Freeman,F |
| 7/26/2021 | | | PHS | 4 | WHC | 1 | Giolito | Sheffield | Anderson,N | Fuentes |
| 7/27/2021 | | | JER | 5 | JOT | 4 | Gonzalez,V | Alcala | Iglesias,R | Happ,I |
| 7/27/2021 | | | HOU | 0 | LAH | 1 | Hendriks | Smyly | | Dubon |
| 7/27/2021 | | | SCA | 3 | LTR | 4 | Garcia,Y | Rogers,Ta | | Cervelli |
| 7/27/2021 | | | CCC | 2 | COL | 3 | Gant | Ryu | Peralta,F | Adames |
| 7/27/2021 | | | LVB | 12 | ISO | 13 | Andriese | Burdi,Z | | Carpenter |
| 7/27/2021 | | | PHS | 7 | WHC | 5 | Cueto | Voth | Winkler | Devers |
| 7/28/2021 | | | JER | 1 | JOT | 5 | Bieber | Singer | | Stanton |
| 7/28/2021 | | | HOU | 1 | LAH | 4 | Slegers | Buehler | Hendriks | Suzuki |
| 7/28/2021 | | | SCA | 2 | LTR | 4 | Lopez,P | Cole,G | Taylor,Bl | Olson |
| 7/28/2021 | | | CCC | 11 | COL | 3 | Corbin | Peralta,F | | Cruz,N |
| 7/28/2021 | | | LVB | 3 | ISO | 5 | Darvish | Anderson,Ty | Antone | Seager,C |
| 7/28/2021 | | | PHS | 3 | WHC | 0 | Cahill | Keller,B | Guerra,Ju | Berti |
| 7/29/2021 | | 13 | JER | 5 | SCA | 9 | Cole,AJ | Rasmussen | | Pollock |
| 7/29/2021 | | | PHS | 4 | LAH | 6 | May,D | Shoemaker | | Voit |
| 7/29/2021 | | | HOU | 2 | LTR | 3 | Fiers | Burnes | Bummer | Hicks |
| 7/29/2021 | | | LVB | 2 | CCC | 8 | Marquez,G | Rogers,Tr | | Realmuto |
| 7/29/2021 | | | ISO | 7 | JOT | 2 | Kim | McCullers | Andriese | Seager,C |
| 7/29/2021 | | | WHC | 3 | COL | 4 | Greinke | Plesac | Quintana | Canha |
| 7/30/2021 | | | JER | 7 | SCA | 4 | Allard | Boyd | | McMahon |
| 7/30/2021 | | | PHS | 2 | LAH | 4 | Keuchel | Brubaker | Valdez,C | Voit |
| 7/30/2021 | | | HOU | 8 | LTR | 1 | Lamet | Zimmer,K | Smyly | Tucker,K |
| 7/30/2021 | | | LVB | 4 | CCC | 11 | Lynn | Cease | | Realmuto |
| 7/30/2021 | | | ISO | 6 | JOT | 2 | Shreve | Castro,M | | Donaldson |
| 7/30/2021 | | 10 | WHC | 10 | COL | 8 | Holland,G | Newsome | Dunning | Pillar |
| 7/31/2021 | | 10 | JER | 4 | SCA | 5 | Stashak | Rasmussen | | Heyward |
| 7/31/2021 | | | PHS | 5 | LAH | 2 | Giolito | Castillo,L | Anderson,N | Maldonado |
| 7/31/2021 | | | HOU | 9 | LTR | 7 | Gallen | Kikuchi | Hahn | Gomes |
| 7/31/2021 | | | LVB | 1 | CCC | 7 | Richards,G | Akin | | Ozuna |
| 7/31/2021 | | | ISO | 5 | JOT | 4 | Wainwright | Flaherty | Antone | Stevenson |
| 7/31/2021 | | | WHC | 2 | COL | 6 | Scherzer | Voth | | Canha |
| 8/1/2021 | | | JER | 8 | JOT | 5 | Iglesias,R | Castro,M | | Acuna |
| 8/1/2021 | | | LAH | 5 | HOU | 6 | Gausman | Woodruff | Hahn | Reyes,F |
| 8/1/2021 | | | LTR | 5 | SCA | 7 | Rogers,Ta | Taylor,Bl | Montero | Guerrero |
| 8/1/2021 | | | CCC | 4 | COL | 3 | Nola,Aa | Lindblom | Diaz,Ed | Ozuna |
| 8/1/2021 | | | ISO | 5 | LVB | 7 | Castellani | Cobb | Teheran | Santander |
| 8/1/2021 | | | WHC | 2 | PHS | 3 | Rainey | Soto,G | Anderson,N | |
| 8/2/2021 | | | JER | 8 | JOT | 9 | Bieber | Singer | Morejon | Stanton |
| 8/2/2021 | | | LAH | 1 | HOU | 5 | Buehler | Garcia,D | Foster | Buxton |
| 8/2/2021 | | | LTR | 5 | SCA | 6 | Stashak | Taylor,Bl | | Yelich |
| 8/2/2021 | | | CCC | 5 | COL | 0 | Ryu | Peralta,F | | Stewart,DJ |
| 8/2/2021 | | | ISO | 2 | LVB | 4 | Robles,H | Andriese | | Pujols |
| 8/2/2021 | | | WHC | 2 | PHS | 1 | Plesac | Cahill | Holland,G | Stewart,C |
| 8/3/2021 | | | JER | 6 | JOT | 5 | Valdez,F | James | Parker | McMahon |
| 8/3/2021 | | | LAH | 5 | HOU | 1 | May,D | Burnes | | Nimmo |
| 8/3/2021 | | 10 | LTR | 2 | SCA | 0 | Webb,T | Montero | Garcia,Y | Hicks |
| 8/3/2021 | | | CCC | 2 | COL | 8 | Greinke | Marquez,G | | Baez,J |
| 8/3/2021 | | | ISO | 3 | LVB | 5 | Stripling | Kim | Garcia,LH | Goodrum |
| 8/3/2021 | | | WHC | 7 | PHS | 3 | Sheffield | Arrieta | | |
| 8/4/2021 | | | JER | 2 | COL | 0 | Allard | Newsome | Iglesias,R | Candelario |
| 8/4/2021 | | | LAH | 0 | PHS | 6 | Brubaker | Keuchel | | Devers |
| 8/4/2021 | | | LTR | 1 | HOU | 8 | Lamet | Fiers | Smith,R | Tucker,K |
| 8/4/2021 | | | WHC | 7 | SCA | 2 | Gallegos | Boyd | | Flowers |
| 8/4/2021 | | | CCC | 18 | LVB | 0 | Lynn | Teheran | | Zimmer,B |
| 8/4/2021 | | | ISO | 6 | JOT | 2 | Clevinger | Bumgarner | Antone | Contreras,WE |
| 8/5/2021 | | | JER | 6 | COL | 11 | Scherzer | Montas | | Turner,J |
| 8/5/2021 | | | LAH | 4 | PHS | 6 | Giolito | Keller,M | Anderson,N | Maldonado |
| 8/5/2021 | | | LTR | 6 | HOU | 1 | Lopez,P | Gallen | | Perez,R |
| 8/5/2021 | | | WHC | 1 | SCA | 2 | Bubic | Keller,B | Romo | Pollock |
| 8/5/2021 | | | CCC | 10 | LVB | 1 | Corbin | Cease | | Lindor |
| 8/5/2021 | | | ISO | 1 | JOT | 5 | Flaherty | Wainwright | Cabrera,G | Stanton |
| 8/6/2021 | | | JER | 3 | COL | 2 | Parker | Peralta,F | Iglesias,R | |
| 8/6/2021 | | | LAH | 15 | PHS | 4 | Woodruff | Cueto | Ramirez,E | Voit |
| 8/6/2021 | | | LTR | 7 | HOU | 6 | Zimmer,K | Gausman | Bummer | Olson |
| 8/6/2021 | | | WHC | 7 | SCA | 1 | Plesac | Wright | | Pillar |
| 8/6/2021 | | | CCC | 11 | LVB | 4 | Nola,Aa | Rogers,Tr | | Ozuna |
| 8/6/2021 | | | ISO | 7 | JOT | 2 | DeSclafani | Alcantara,Sa | Andriese | Freeman,F |
| 8/7/2021 | | | JER | 7 | LVB | 2 | Maton | Anderson,Ty | Iglesias,R | McMahon |
| 8/7/2021 | | | LAH | 1 | SCA | 11 | Wacha | Castillo,L | | Pollock |
| 8/7/2021 | | 11 | WHC | 1 | HOU | 2 | Hahn | Holland,G | | Machado |
| 8/7/2021 | | | CCC | 1 | JOT | 7 | Bieber | Ryu | | Murphy,S |
| 8/7/2021 | | | ISO | 3 | COL | 2 | Darvish | Pagan | Antone | Hilliard |
| 8/7/2021 | | | LTR | 5 | PHS | 0 | Peterson,D | Cahill | Taylor,Bl | Soto,J |
| 8/8/2021 | | | JER | 5 | LVB | 7 | Garcia,LH | Parker | | Jimenez,E |
| 8/8/2021 | | | LAH | 5 | SCA | 0 | May,D | Turnbull | | Ramirez,J |
| 8/8/2021 | | | WHC | 3 | HOU | 6 | Burnes | Voth | | Tatis |
| 8/8/2021 | | | CCC | 1 | JOT | 5 | McCullers | Marquez,G | Alcala | |
| 8/8/2021 | | 11 | ISO | 4 | COL | 5 | Kay | Harvey,H | | Kirk |
| 8/8/2021 | | | LTR | 9 | PHS | 2 | Kikuchi | Arrieta | | France |
| 8/9/2021 | | | JER | 12 | LVB | 5 | Roark | Akin | Gonzalez,V | Verdugo |
| 8/9/2021 | | 10 | LAH | 4 | SCA | 3 | Perez,O | Montero | Hendriks | Ruf |
| 8/9/2021 | | | WHC | 2 | HOU | 3 | Lamet | Hatch | Hahn | Machado |
| 8/9/2021 | | | CCC | 2 | JOT | 4 | Alcala | Lynn | Castro,M | Moustakas |
| 8/9/2021 | | | ISO | 4 | COL | 1 | Andriese | Newsome | Antone | Guillorme |
| 8/9/2021 | | 10 | LTR | 8 | PHS | 9 | Merryweather | Duffey | | Bryant |
| 8/10/2021 | | | JER | 13 | LVB | 5 | Montas | Castellani | | Candelario |
| 8/10/2021 | | | LAH | 8 | SCA | 0 | Garcia,D | Bubic | | Ramirez,J |
| 8/10/2021 | | | WHC | 2 | HOU | 1 | Hatch | Minter | Suero | Ward |
| 8/10/2021 | | | CCC | 11 | JOT | 9 | Diaz,Ed | Reyes,A | Cisnero | Straw |
| 8/10/2021 | | | ISO | 4 | COL | 2 | Wainwright | Scherzer | Harvey,H | Contreras,WE |
| 8/10/2021 | | | LTR | 1 | PHS | 3 | Giolito | Lopez,P | Anderson,N | Higashioka |
| 8/12/2021 | | | JOT | 1 | JER | 7 | Junis | Alcantara,Sa | | Candelario |
| 8/12/2021 | | | HOU | 9 | LAH | 4 | Gausman | Woodruff | | Tatis |
| 8/12/2021 | | | SCA | 1 | LTR | 2 | Zimmer,K | Wright | Taylor,Bl | Hicks |
| 8/12/2021 | | | COL | 7 | CCC | 3 | Lindblom | Corbin | | Escobar |
| 8/12/2021 | | | LVB | 2 | ISO | 10 | Cobb | Cease | DeSclafani | Guillorme |
| 8/12/2021 | | | PHS | 5 | WHC | 6 | Holland,G | Kinley | | Frazier,A |
| 8/13/2021 | | | JOT | 3 | JER | 2 | Bieber | Gonzalez,V | Castro,M | Bader |
| 8/13/2021 | | | HOU | 6 | LAH | 3 | Buehler | Castillo,L | Hahn | Machado |
| 8/13/2021 | | | SCA | 4 | LTR | 1 | Cole,G | Eflin | Montero | Shaw,T |
| 8/13/2021 | | | COL | 1 | CCC | 2 | Nola,Aa | Greinke | Hand | Stewart,DJ |
| 8/13/2021 | | | LVB | 2 | ISO | 9 | Darvish | Anderson,Ty | | Seager,C |
| 8/13/2021 | | | PHS | 5 | WHC | 4 | Guerra,Ju | Soto,G | Anderson,N | Mondesi |
| 8/14/2021 | | | JOT | 4 | JER | 5 | Gonzalez,V | Alcala | Iglesias,R | Happ,I |
| 8/14/2021 | | | HOU | 2 | LAH | 6 | Houck | Burnes | | Voit |
| 8/14/2021 | | | SCA | 5 | LTR | 7 | Webb,T | Rogers,Ta | Weems | Rios,E |
| 8/14/2021 | | | COL | 0 | CCC | 2 | Ryu | Peralta,F | | |
| 8/14/2021 | | | LVB | 4 | ISO | 6 | Kim | Stratton | Antone | Stevenson |
| 8/14/2021 | | | PHS | 2 | WHC | 3 | Keller,B | Arrieta | Holland,G | O'Neill |
| 8/15/2021 | | | COL | 1 | JER | 3 | Britton | Scherzer | Iglesias,R | Verdugo |
| 8/15/2021 | | | PHS | 0 | LAH | 8 | Keuchel | Brubaker | | Gardner |
| 8/15/2021 | | | HOU | 1 | LTR | 2 | Zimmer,K | Lamet | Yates | Hicks |
| 8/15/2021 | | | SCA | 0 | WHC | 1 | Holland,G | Stashak | | Mendick |
| 8/15/2021 | | | LVB | 1 | CCC | 13 | Marquez,G | Rogers,Tr | | |
| 8/15/2021 | | | JOT | 6 | ISO | 1 | Bumgarner | Clevinger | | Villar |
| 8/16/2021 | | | COL | 0 | JER | 3 | O'Day | Newsome | Iglesias,R | Crawford,JP |
| 8/16/2021 | | | PHS | 2 | LAH | 5 | Dolis | Kinley | Hendriks | Swanson,D |
| 8/16/2021 | | 14 | HOU | 6 | LTR | 4 | Smyly | Curtiss | | Machado |
| 8/16/2021 | | | SCA | 1 | WHC | 6 | Hatch | Bubic | Holland,G | Martinez,Jo |
| 8/16/2021 | | | LVB | 2 | CCC | 14 | Lynn | Castellani | | Ozuna |
| 8/16/2021 | | | JOT | 4 | ISO | 5 | DeSclafani | Castro,M | | Pederson |
| 8/17/2021 | | 11 | COL | 6 | JER | 7 | Britton | Quintana | | Reynolds,B |
| 8/17/2021 | | | PHS | 0 | LAH | 4 | Woodruff | Cueto | Hendriks | Gardner |
| 8/17/2021 | | | HOU | 6 | LTR | 5 | Smith,R | Curtiss | Foster | Machado |
| 8/17/2021 | | | SCA | 7 | WHC | 10 | Gallegos | Wright | Holland,G | Frazier,A |
| 8/17/2021 | | | LVB | 5 | CCC | 6 | Richards,G | Cease | | Rizzo |
| 8/17/2021 | | | JOT | 3 | ISO | 4 | Antone | Alcala | | Seager,C |
| 8/19/2021 | | 11 | JER | 7 | PUR | 4 | Gonzalez,V | Jeffress | Iglesias,R | Acuna |
| 8/19/2021 | | 12 | LAH | 8 | SMC | 9 | Ramirez,No | Thielbar | | Abreu,J |
| 8/19/2021 | | | HOU | 8 | PLU | 3 | Buehler | Gonsolin | | Springer |
| 8/19/2021 | | | SCA | 2 | NHH | 9 | Brault | Wacha | | Guzman,R |
| 8/19/2021 | | | CCC | 1 | BEA | 4 | Thompson | Corbin | Fry,P | Cano |
| 8/19/2021 | | | ISO | 8 | PAN | 4 | Darvish | Matz | | Contreras,WE |
| 8/19/2021 | | | LTR | 9 | CYC | 2 | Dobnak | Heaney | | Rojas,M |
| 8/19/2021 | | | PHS | 0 | GOT | 8 | Gray,S | Cahill | | Grisham |
| 8/19/2021 | | | WHC | 3 | BOM | 5 | deGrom | Keller,B | Colome | LeMahieu |
| 8/19/2021 | | | JOT | 4 | SEA | 0 | Bieber | Bassitt | | Peralta,D |
| 8/19/2021 | | | COL | 2 | ATK | 7 | Fried | Greinke | Karinchak | Valaika |
| 8/19/2021 | | | LVB | 7 | NUT | 15 | Crichton | Stripling | | Fletcher,D |
| 8/20/2021 | | | JER | 6 | PUR | 4 | Valdez,F | Freeland | Iglesias,R | Semien |
| 8/20/2021 | | 12 | LAH | 8 | SMC | 3 | Perez,O | Loup | | Voit |
| 8/20/2021 | | | HOU | 3 | PLU | 4 | Garcia,B | Smyly | | Marte,K |
| 8/20/2021 | | | SCA | 3 | NHH | 5 | Allen,L | Turnbull | Quantrill | Kipnis |
| 8/20/2021 | | | CCC | 5 | BEA | 8 | Porcello | Marquez,G | Jansen,K | Harper,B |
| 8/20/2021 | | | ISO | 5 | PAN | 3 | Kim | Civale | Antone | Seager,C |
| 8/20/2021 | | | LTR | 12 | CYC | 7 | Zimmer,K | Wilson,J | | Soto,J |
| 8/20/2021 | | | PHS | 4 | GOT | 2 | Shoemaker | Kershaw | Anderson,N | Profar |
| 8/20/2021 | | | WHC | 4 | BOM | 9 | Hendricks | Plesac | Castillo,D | Brantley |
| 8/20/2021 | | | JOT | 9 | SEA | 3 | McCullers | Snell | | Peralta,D |
| 8/20/2021 | | | COL | 1 | ATK | 4 | Yarbrough | Scherzer | Martin,C | Franco |
| 8/20/2021 | | | LVB | 4 | NUT | 14 | Senzatela | Anderson,Ty | | Longoria |
| 8/21/2021 | | | JER | 1 | PUR | 2 | Canning | Roark | Young,Al | Gurriel,L |
| 8/21/2021 | | | LAH | 8 | SMC | 0 | Keuchel | Walker,T | | Meadows |
| 8/21/2021 | | | HOU | 7 | PLU | 1 | Lamet | Davies | | Kelly,C |
| 8/21/2021 | | | SCA | 11 | NHH | 2 | Boyd | Minor | | Pollock |
| 8/21/2021 | | | CCC | 8 | BEA | 4 | Lynn | Mize | | Rizzo |
| 8/21/2021 | | | ISO | 2 | PAN | 1 | Clevinger | Duffy | Antone | Slater |
| 8/21/2021 | | | LTR | 10 | CYC | 3 | Peterson,D | Garrett,B | | Tellez |
| 8/21/2021 | | | PHS | 0 | GOT | 3 | Familia | Brubaker | Green | Kepler |
| 8/21/2021 | | | WHC | 3 | BOM | 7 | Wheeler | Sheffield | | Brosseau |
| 8/21/2021 | | | JOT | 9 | SEA | 3 | Bumgarner | Mahle | Alcala | Anderson,Ti |
| 8/21/2021 | | | COL | 3 | ATK | 5 | Treinen | Kay | Williams,D | Yastrzemski |
| 8/21/2021 | | | LVB | 2 | NUT | 12 | Javier | Akin | | Iglesias,J |
| 8/22/2021 | | | PUR | 4 | JER | 3 | Staumont | Montas | Jeffress | Crawford,B |
| 8/22/2021 | | | SMC | 0 | LAH | 4 | Woodruff | Luzardo | | Merrifield |
| 8/22/2021 | | | PLU | 1 | HOU | 2 | Gallen | Glasnow | Hahn | Reyes,F |
| 8/22/2021 | | | NHH | 8 | SCA | 7 | Tepera | Stashak | Quantrill | Stassi |
| 8/22/2021 | | | BEA | 2 | CCC | 12 | Nola,Aa | Paddack | Reid-Foley | Realmuto |
| 8/22/2021 | | | PAN | 4 | ISO | 8 | Wainwright | Dunn | | Seager,C |
| 8/22/2021 | | | CYC | 12 | LTR | 4 | Wilson,J | Taylor,Bl | Alexander,T | Bradley,J |
| 8/22/2021 | | | GOT | 8 | PHS | 11 | Rainey | Tanaka | Anderson,N | Higashioka |
| 8/22/2021 | | | BOM | 17 | WHC | 2 | Urias,J | Voth | Suter | Winker |
| 8/22/2021 | | | SEA | 2 | JOT | 1 | Carrasco | Castro,M | Bard,D | Hosmer |
| 8/22/2021 | | | ATK | 2 | COL | 4 | Lindblom | Skubal | Pagan | Turner,J |
| 8/22/2021 | | | NUT | 5 | LVB | 3 | Fedde | Cease | Dayton | Bohm |
| 8/23/2021 | | | PUR | 2 | JER | 15 | Weaver | Eshelman | | Candelario |
| 8/23/2021 | | | SMC | 5 | LAH | 1 | Anderson,I | Garcia,D | | Simmons |
| 8/23/2021 | | | PLU | 4 | HOU | 1 | Maeda | Gausman | Garcia,B | DeShields |
| 8/23/2021 | | | NHH | 4 | SCA | 1 | Ynoa | Wright | Quantrill | Kipnis |
| 8/23/2021 | | | BEA | 12 | CCC | 4 | Sanchez,An | Ryu | | Smith,WD |
| 8/23/2021 | | | PAN | 1 | ISO | 2 | Cobb | Musgrove | Antone | Betts |
| 8/23/2021 | | | CYC | 12 | LTR | 2 | Wilson,J | Lopez,P | | Bemboom |
| 8/23/2021 | | | GOT | 12 | PHS | 7 | Lester | Cueto | | Smith,Do |
| 8/23/2021 | | | BOM | 2 | WHC | 4 | Keller,B | Houser | Holland,G | Hoskins |
| 8/23/2021 | | | SEA | 4 | JOT | 8 | Alcantara,Sa | Fleming | James | Bader |
| 8/23/2021 | | | ATK | 6 | COL | 8 | Newsome | Tomlin | Pagan | Akiyama |
| 8/23/2021 | | | NUT | 9 | LVB | 5 | Perez,Ma | Castellani | | Fletcher,D |
| 8/24/2021 | | | PUR | 5 | JER | 7 | Maton | Hudson,Dak | Iglesias,R | Acuna |
| 8/24/2021 | | | SMC | 5 | LAH | 6 | Perez,O | Greene | Hendriks | Ramirez,J |
| 8/24/2021 | | | PLU | 5 | HOU | 6 | Buehler | Sanchez,S | Hahn | Tucker,K |
| 8/24/2021 | | | NHH | 4 | SCA | 6 | Cole,G | Brault | Montero | Yelich |
| 8/24/2021 | | | BEA | 7 | CCC | 4 | Bundy | Corbin | Jansen,K | |
| 8/24/2021 | | | PAN | 1 | ISO | 8 | Darvish | Lopez,J | | |
| 8/24/2021 | | | CYC | 6 | LTR | 3 | Heaney | Fiers | | Bradley,J |
| 8/24/2021 | | | GOT | 3 | PHS | 8 | Pena | Gray,S | Hernandez,D | Devers |
| 8/24/2021 | | | BOM | 0 | WHC | 2 | Plesac | deGrom | Sims | Mullins |
| 8/24/2021 | | | SEA | 6 | JOT | 2 | Bassitt | Bieber | | Braun |
| 8/24/2021 | | | ATK | 7 | COL | 5 | Fried | Greinke | Martin,C | Long |
| 8/24/2021 | | | NUT | 7 | LVB | 1 | Bauer | Stripling | | Calhoun,K |
| 8/26/2021 | | | LVB | 6 | JER | 11 | Valdez,F | Anderson,Ty | | Crawford,JP |
| 8/26/2021 | | | SCA | 1 | LAH | 4 | May,D | Turnbull | Hendriks | Gardner |
| 8/26/2021 | | | HOU | 3 | WHC | 1 | Smyly | Sheffield | Hahn | Madrigal |
| 8/26/2021 | | | JOT | 5 | CCC | 7 | Richards,G | McCullers | Hand | Stewart,DJ |
| 8/26/2021 | | | COL | 0 | ISO | 9 | Kim | Scherzer | | Eaton |
| 8/26/2021 | | | PHS | 7 | LTR | 4 | Merryweather | Webb,T | Anderson,N | Berti |
| 8/27/2021 | | | LVB | 5 | JER | 6 | Gonzalez,V | Akin | Iglesias,R | Semien |
| 8/27/2021 | | | SCA | 4 | LAH | 7 | Hendriks | Cole,AJ | | Taylor,C |
| 8/27/2021 | | | HOU | 10 | WHC | 3 | Lamet | Voth | | Walker,C |
| 8/27/2021 | | 10 | JOT | 2 | CCC | 4 | Miller,A | Alcala | | Zimmer,B |
| 8/27/2021 | | | COL | 1 | ISO | 6 | Clevinger | Lindblom | DeSclafani | Seager,C |
| 8/27/2021 | | | PHS | 3 | LTR | 4 | Taylor,Bl | Rainey | Yates | Tellez |
| 8/28/2021 | | | LVB | 5 | JER | 11 | Maton | Cease | Parker | Mathis |
| 8/28/2021 | | | SCA | 8 | LAH | 3 | Bubic | Keuchel | | Pollock |
| 8/28/2021 | | | HOU | 0 | WHC | 1 | Keller,B | Gallen | | Galvis |
| 8/28/2021 | | | JOT | 4 | CCC | 1 | Morejon | Lynn | Castro,M | Peralta,D |
| 8/28/2021 | | | COL | 9 | ISO | 8 | Newsome | Andriese | | Baez,J |
| 8/28/2021 | | 11 | PHS | 2 | LTR | 3 | Zimmer,K | Anderson,N | | Tellez |
| 8/29/2021 | | | HOU | 5 | JER | 4 | Foster | Gonzalez,V | Hahn | Tatis |
| 8/29/2021 | | | LAH | 4 | JOT | 2 | Castillo,L | Alcantara,Sa | Hendriks | Voit |
| 8/29/2021 | | | SCA | 0 | CCC | 1 | Nola,Aa | Wright | Mayers | Cruz,N |
| 8/29/2021 | | | PHS | 1 | ISO | 4 | Cobb | Cueto | Antone | Eaton |
| 8/29/2021 | | | LTR | 3 | COL | 7 | Greinke | Kikuchi | Quintana | Adames |
| 8/29/2021 | | | WHC | 7 | LVB | 0 | Plesac | Teheran | | Grandal |
| 8/30/2021 | | | HOU | 6 | JER | 4 | Foster | Gonzalez,V | Hahn | Walker,C |
| 8/30/2021 | | | LAH | 3 | JOT | 6 | Bieber | Keller,M | Morejon | Stanton |
| 8/30/2021 | | | SCA | 3 | CCC | 2 | Cole,G | Ryu | Montero | Guerrero |
| 8/30/2021 | | 13 | PHS | 2 | ISO | 3 | Givens | Hernandez,D | | Stevenson |
| 8/30/2021 | | | LTR | 7 | COL | 9 | Quintana | Peterson,D | Newsome | Chavis |
| 8/30/2021 | | | WHC | 8 | LVB | 6 | Hatch | Castellani | Holland,G | Hoskins |
| 8/31/2021 | | | HOU | 9 | JER | 1 | Burnes | Valdez,F | | Machado |
| 8/31/2021 | | | LAH | 8 | JOT | 4 | May,D | McCullers | Dolis | Merrifield |
| 8/31/2021 | | | SCA | 5 | CCC | 8 | Cisnero | Turnbull | Miller,A | Ozuna |
| 8/31/2021 | | | PHS | 9 | ISO | 4 | Merryweather | Harvey,H | | Miller,B |
| 8/31/2021 | | | LTR | 0 | COL | 7 | Scherzer | Fiers | | Escobar |
| 8/31/2021 | | | WHC | 7 | LVB | 5 | Voth | Anderson,Ty | Holland,G | Hoskins |
| 9/2/2021 | | | JER | 0 | GOT | 7 | Green | Roark | | Grisham |
| 9/2/2021 | | | LAH | 7 | PAN | 2 | Woodruff | Matz | Dolis | Ramirez,J |
| 9/2/2021 | | | HOU | 6 | SEA | 4 | Armstrong | Kintzler | Hahn | Springer |
| 9/2/2021 | | 11 | SCA | 9 | ATK | 11 | Karinchak | Montero | | Votto |
| 9/2/2021 | | | CCC | 2 | PLU | 3 | Gonsolin | Richards,G | Scott | Soler |
| 9/2/2021 | | | ISO | 0 | NHH | 14 | Minor | Clevinger | | Wendle |
| 9/2/2021 | | | LTR | 5 | PUR | 2 | Lopez,P | Canning | | Cervelli |
| 9/2/2021 | | | PHS | 1 | NUT | 6 | Javier | Brubaker | | Bohm |
| 9/2/2021 | | | WHC | 8 | BEA | 6 | Keller,B | King,M | Holland,G | O'Neill |
| 9/2/2021 | | | JOT | 2 | BOM | 4 | Wheeler | Cabrera,G | Colome | Story |
| 9/2/2021 | | | COL | 5 | SMC | 11 | Walker,T | Lindblom | Lugo,S | d'Arnaud |
| 9/2/2021 | | | LVB | 9 | CYC | 5 | Garcia,LH | Strahm | | Goodrum |
| 9/3/2021 | | | JER | 2 | GOT | 10 | Tanaka | Montas | | Laureano |
| 9/3/2021 | | | LAH | 2 | PAN | 5 | Turley | Keuchel | Hudson,Dan | McNeil |
| 9/3/2021 | | | HOU | 1 | SEA | 5 | Carrasco | Gallen | Bard,D | Upton |
| 9/3/2021 | | | SCA | 3 | ATK | 6 | Skubal | Bubic | Graterol | Valaika |
| 9/3/2021 | | | CCC | 6 | PLU | 2 | Marquez,G | Gibson | | Hernandez,Ce |
| 9/3/2021 | | | ISO | 6 | NHH | 2 | Wainwright | Gray,J | | Contreras,WE |
| 9/3/2021 | | | LTR | 2 | PUR | 5 | Webb,L | Eflin | Jeffress | Crawford,B |
| 9/3/2021 | | | PHS | 1 | NUT | 0 | Giolito | Fedde | Anderson,N | Berti |
| 9/3/2021 | | | WHC | 2 | BEA | 5 | Pomeranz | Plesac | Rosenthal | Harper,B |
| 9/3/2021 | | | JOT | 4 | BOM | 8 | Urias,J | Flaherty | | Story |
| 9/3/2021 | | | COL | 4 | SMC | 2 | Greinke | Luzardo | Pagan | Turner,J |
| 9/3/2021 | | | LVB | 2 | CYC | 8 | Heaney | Cease | | Rosario,E |
| 9/4/2021 | | 10 | JER | 8 | GOT | 9 | Green | Iglesias,R | | Smith,Do |
| 9/4/2021 | | | LAH | 4 | PAN | 8 | Duffy | Castillo,L | | Smith,M |
| 9/4/2021 | | | HOU | 2 | SEA | 1 | Gausman | Fleming | Hahn | Springer |
| 9/4/2021 | | | SCA | 1 | ATK | 8 | Tomlin | Wright | Lorenzen | Solak |
| 9/4/2021 | | | CCC | 13 | PLU | 4 | Lynn | Davies | Reid-Foley | Rendon |
| 9/4/2021 | | | ISO | 4 | NHH | 8 | Tepera | DeSclafani | | Barnes,A |
| 9/4/2021 | | | LTR | 11 | PUR | 3 | Dobnak | Eshelman | | Hicks |
| 9/4/2021 | | | PHS | 4 | NUT | 3 | Rainey | Fairbanks | Anderson,N | Miller,B |
| 9/4/2021 | | | WHC | 3 | BEA | 4 | Sanchez,An | Sheffield | Jansen,K | |
| 9/4/2021 | | | JOT | 3 | BOM | 1 | Alcantara,Sa | Houser | Castro,M | Peralta,D |
| 9/4/2021 | | | COL | 5 | SMC | 4 | Kay | May,T | | |
| 9/4/2021 | | | LVB | 8 | CYC | 9 | Norris | Stripling | Pressly | Ahmed |
| 9/6/2021 | | | GOT | 2 | JER | 3 | Gonzalez,V | Gray,S | Iglesias,R | Crawford,JP |
| 9/6/2021 | | | PAN | 4 | LAH | 6 | Garcia,D | Dunn | Hendriks | Voit |
| 9/6/2021 | | 13 | SEA | 2 | HOU | 1 | Bard,D | Smyly | Baragar | Blackmon |
| 9/6/2021 | | | ATK | 8 | SCA | 4 | Fried | Wacha | | Long |
| 9/6/2021 | | | PLU | 0 | CCC | 10 | Nola,Aa | Glasnow | | Ozuna |
| 9/6/2021 | | | NHH | 6 | ISO | 4 | Allen,L | Antone | Quantrill | Conforto |
| 9/6/2021 | | | PUR | 4 | LTR | 5 | Peterson,D | Hudson,Dak | Webb,T | Cervelli |
| 9/6/2021 | | | NUT | 1 | PHS | 2 | Cody | Bauer | Anderson,N | Solano |
| 9/6/2021 | | | BEA | 5 | WHC | 4 | Fry,P | Holland,G | Jansen,K | Judge |
| 9/6/2021 | | | BOM | 1 | JOT | 2 | Castro,M | Castillo,D | | Murphy,S |
| 9/6/2021 | | | SMC | 12 | COL | 10 | Matzek | Newsome | Melancon | Abreu,J |
| 9/6/2021 | | | CYC | 5 | LVB | 6 | Stratton | Pressly | | Suarez,E |
| 9/7/2021 | | | GOT | 1 | JER | 2 | Valdez,F | Kershaw | Iglesias,R | Candelario |
| 9/7/2021 | | | PAN | 5 | LAH | 8 | Houck | Heuer | Hendriks | Ruf |
| 9/7/2021 | | | SEA | 9 | HOU | 12 | Burnes | Snell | Hahn | Springer |
| 9/7/2021 | | 12 | ATK | 5 | SCA | 6 | Cole,AJ | Martin,C | | Yelich |
| 9/7/2021 | | | PLU | 3 | CCC | 8 | Ryu | Maeda | | Cruz,N |
| 9/7/2021 | | | NHH | 4 | ISO | 8 | Antone | Barria | | Betts |
| 9/7/2021 | | | PUR | 3 | LTR | 4 | Duffey | Jeffress | | Rios,E |
| 9/7/2021 | | | NUT | 3 | PHS | 1 | Senzatela | Guerra,Ju | Dayton | Calhoun,K |
| 9/7/2021 | | | BEA | 3 | WHC | 4 | Suero | Rosenthal | | O'Neill |
| 9/7/2021 | | | BOM | 7 | JOT | 8 | Holland,D | Tate | Reyes,A | |
| 9/7/2021 | | | SMC | 4 | COL | 2 | Gonzales | Lindblom | Melancon | Anderson,Bri |
| 9/7/2021 | | | CYC | 7 | LVB | 8 | Garcia,LH | Strahm | | Kieboom |
| 9/8/2021 | | | GOT | 4 | JER | 14 | Allard | Alzolay | | Perez,S |
| 9/8/2021 | | | PAN | 7 | LAH | 4 | Trivino | Valdez,C | Hudson,Dan | Tapia,R |
| 9/8/2021 | | | SEA | 1 | HOU | 3 | Lamet | Mahle | Hahn | Tatis |
| 9/8/2021 | | | ATK | 3 | SCA | 1 | Montgomery,J | Boyd | Karinchak | McCann |
| 9/8/2021 | | | PLU | 9 | CCC | 3 | Sanchez,S | Corbin | Bass | Soler |
| 9/8/2021 | | | NHH | 5 | ISO | 4 | Minor | Clevinger | Quantrill | Barnes,A |
| 9/8/2021 | | | PUR | 12 | LTR | 3 | Canning | Lopez,P | | La Stella |
| 9/8/2021 | | | NUT | 5 | PHS | 20 | Brubaker | Javier | | Higashioka |
| 9/8/2021 | | | BEA | 0 | WHC | 6 | Plesac | Mize | | Stewart,C |
| 9/8/2021 | | | BOM | 5 | JOT | 4 | Wheeler | Bumgarner | Colome | Story |
| 9/8/2021 | | | SMC | 10 | COL | 4 | Lugo,S | Greinke | Ramirez,No | Abreu,J |
| 9/8/2021 | | | CYC | 4 | LVB | 3 | Wilson,J | Stratton | Pressly | Rosario,E |
| 9/9/2021 | | | JER | 0 | PHS | 13 | Giolito | Montas | | Joyce |
| 9/9/2021 | | | WHC | 2 | LAH | 4 | Hendriks | Sheffield | Valdez,C | Ruf |
| 9/9/2021 | | | SCA | 8 | HOU | 0 | Bubic | Gallen | | Guerrero |
| 9/9/2021 | | 11 | ISO | 8 | CCC | 7 | Andriese | Hand | Antone | Guillorme |
| 9/9/2021 | | | LVB | 4 | LTR | 5 | Taylor,Bl | Robles,H | Yates | Rios,E |
| 9/9/2021 | | | COL | 1 | JOT | 5 | Flaherty | Peralta,F | | Peralta,D |
| 9/10/2021 | | | JER | 9 | PHS | 14 | Cueto | Junis | | Joyce |
| 9/10/2021 | | | WHC | 1 | LAH | 7 | Keuchel | Voth | | Nimmo |
| 9/10/2021 | | | SCA | 5 | HOU | 9 | Gausman | Wright | Minter | Springer |
| 9/10/2021 | | | ISO | 8 | CCC | 11 | Lynn | Cobb | | Kiermaier |
| 9/10/2021 | | | LVB | 0 | LTR | 12 | Dobnak | Castellani | Garcia,Y | Maybin |
| 9/10/2021 | | | COL | 3 | JOT | 5 | Alcantara,Sa | Chatwood | Cabrera,G | Anderson,Ti |
| 9/11/2021 | | | JER | 3 | PHS | 7 | Cody | Singer | Rainey | Profar |
| 9/11/2021 | | | WHC | 5 | LAH | 9 | Valdez,C | Holland,G | | Turner,T |
| 9/11/2021 | | | SCA | 3 | HOU | 5 | Buehler | Cole,G | Minter | Buxton |
| 9/11/2021 | | | ISO | 8 | CCC | 3 | Darvish | Richards,G | | Stevenson |
| 9/11/2021 | | | LVB | 3 | LTR | 8 | Eflin | Teheran | | Vogelbach |
| 9/11/2021 | | | COL | 3 | JOT | 2 | Gant | Cabrera,G | Newsome | Adames |
| 9/12/2021 | | | JER | 13 | PHS | 7 | Valdez,F | Arrieta | | Perez,S |
| 9/12/2021 | | | LVB | 0 | LTR | 7 | Duffey | Anderson,Ty | | Maybin |
| 9/13/2021 | | | PHS | 5 | JER | 6 | Britton | Shoemaker | Iglesias,R | Happ,I |
| 9/13/2021 | | | LAH | 7 | WHC | 4 | Slegers | Holland,G | Hendriks | Turner,T |
| 9/13/2021 | | | HOU | 3 | SCA | 1 | Burnes | Turnbull | Hahn | Segura |
| 9/13/2021 | | | CCC | 0 | ISO | 7 | Kim | Nola,Aa | Antone | Seager,C |
| 9/13/2021 | | | LTR | 6 | LVB | 8 | Stratton | Taylor,Bl | | Jimenez,E |
| 9/13/2021 | | | JOT | 13 | COL | 5 | McCullers | Greinke | | Peralta,D |
| 9/14/2021 | | | PHS | 3 | JER | 9 | Montas | Giolito | O'Day | Candelario |
| 9/14/2021 | | | LAH | 4 | WHC | 2 | May,D | Sheffield | Hendriks | Ruf |
| 9/14/2021 | | | HOU | 7 | SCA | 1 | Lamet | Boyd | | Machado |
| 9/14/2021 | | | CCC | 4 | ISO | 5 | Antone | Miller,A | | Betts |
| 9/14/2021 | | | LTR | 15 | LVB | 2 | Fiers | Akin | | Soto,J |
| 9/14/2021 | | | JOT | 0 | COL | 8 | Lindblom | Bumgarner | Peralta,F | Turner,J |
| 9/15/2021 | | | PHS | 9 | JER | 4 | Cueto | Weaver | | Diaz,A |
| 9/15/2021 | | | LAH | 4 | WHC | 3 | Dolis | Voth | Thielbar | Dubon |
| 9/15/2021 | | 14 | HOU | 7 | SCA | 8 | Barnes,M | Hahn | | Pollock |
| 9/15/2021 | | | CCC | 3 | ISO | 7 | Wainwright | Marquez,G | | Seager,C |
| 9/15/2021 | | | LTR | 7 | LVB | 1 | Lopez,P | Rogers,Tr | | Hicks |
| 9/15/2021 | | | JOT | 4 | COL | 1 | Cabrera,G | Kay | Castro,M | Peralta,D |
| 9/16/2021 | | | ISO | 5 | JER | 7 | Singer | Cobb | Iglesias,R | Happ,I |
| 9/16/2021 | | | LAH | 3 | LTR | 9 | Zimmer,K | Keuchel | | Garcia,Av |
| 9/16/2021 | | | CCC | 0 | HOU | 1 | Minter | Lynn | | Walker,C |
| 9/16/2021 | | | PHS | 6 | SCA | 0 | Rainey | Wright | | Schwarber |
| 9/16/2021 | | | JOT | 2 | WHC | 1 | Alcantara,Sa | Holland,G | Castro,M | Frazier,C |
| 9/16/2021 | | | LVB | 10 | COL | 14 | Gant | Burdi,Z | | Olivares |
| 9/17/2021 | | | ISO | 0 | JER | 3 | Valdez,F | Darvish | | Candelario |
| 9/17/2021 | | | LAH | 8 | LTR | 4 | Castillo,L | Eflin | Dolis | Voit |
| 9/17/2021 | | | CCC | 9 | HOU | 5 | Corbin | Buehler | Hand | Cruz,N |
| 9/17/2021 | | | PHS | 2 | SCA | 4 | Cole,G | Arrieta | Clippard | Heyward |
| 9/17/2021 | | | JOT | 4 | WHC | 1 | Bieber | Plesac | Reyes,A | Ramos,W |
| 9/17/2021 | | | LVB | 0 | COL | 9 | Newsome | Stripling | | Chavis |
| 9/18/2021 | | 11 | ISO | 5 | JER | 6 | Parker | Givens | | Acuna |
| 9/18/2021 | | | LAH | 7 | LTR | 4 | Dolis | Webb,T | Slegers | Castro,W |
| 9/18/2021 | | | CCC | 8 | HOU | 2 | Nola,Aa | Burnes | | Rizzo |
| 9/18/2021 | | | PHS | 3 | SCA | 6 | Turnbull | Shoemaker | Montero | Bogaerts |
| 9/18/2021 | | | JOT | 9 | WHC | 6 | McCullers | Sheffield | Alcala | Cabrera,A |
| 9/18/2021 | | | LVB | 5 | COL | 7 | Greinke | Anderson,Ty | Pagan | Baez,J |
| 9/19/2021 | | | CCC | 3 | HOU | 2 | Ryu | Lamet | Hand | Rizzo |
| 9/19/2021 | | | JOT | 7 | WHC | 12 | Sims | Bumgarner | | Pillar |
| 9/20/2021 | | | JER | 6 | ISO | 12 | Clevinger | Montas | Andriese | Seager,C |
| 9/20/2021 | | | LTR | 3 | LAH | 6 | Smith,B | Webb,T | Paredes,E | Suzuki |
| 9/20/2021 | | 11 | HOU | 6 | CCC | 7 | Hand | Minter | | Wallach |
| 9/20/2021 | | | SCA | 0 | PHS | 9 | Giolito | Boyd | | Mondesi |
| 9/20/2021 | | | WHC | 9 | JOT | 0 | Keller,B | Flaherty | | Frazier,A |
| 9/20/2021 | | | COL | 2 | LVB | 1 | Peralta,F | Robles,H | | Narvaez |
| 9/21/2021 | | | JER | 3 | ISO | 6 | Wainwright | Weaver | Antone | Seager,C |
| 9/21/2021 | | | LTR | 3 | LAH | 1 | Fiers | May,D | Yates | France |
| 9/21/2021 | | | HOU | 9 | CCC | 7 | Gausman | Marquez,G | Foster | Springer |
| 9/21/2021 | | | SCA | 4 | PHS | 9 | Kinley | Cole,AJ | | Duvall |
| 9/21/2021 | | | WHC | 4 | JOT | 1 | Plesac | Alcantara,Sa | Suero | Galvis |
| 9/21/2021 | | | COL | 9 | LVB | 6 | Scherzer | Akin | Peralta,F | Escobar |
| 9/22/2021 | | | JER | 4 | ISO | 9 | Cobb | Singer | | Eaton |
| 9/22/2021 | | | LTR | 7 | LAH | 5 | Duffey | Hendriks | | Vogelbach |
| 9/22/2021 | | | HOU | 7 | CCC | 6 | Buehler | Lynn | Smith,R | Tatis |
| 9/22/2021 | | | SCA | 2 | PHS | 7 | Guerra,Ju | Wright | Rainey | Duvall |
| 9/22/2021 | | | WHC | 0 | JOT | 7 | Bieber | Sheffield | | Murphy,S |
| 9/22/2021 | | | COL | 1 | LVB | 2 | Garcia,LH | Kay | | Sisco |
| 9/23/2021 | | | CCC | 2 | JER | 1 | Corbin | Valdez,F | Miller,A | Realmuto |
| 9/23/2021 | | | LAH | 4 | COL | 0 | Castillo,L | Greinke | Dolis | Suzuki |
| 9/23/2021 | | | HOU | 8 | PHS | 0 | Burnes | Arrieta | | Tatis |
| 9/23/2021 | | 11 | SCA | 2 | ISO | 1 | Montero | Antone | | Heyward |
| 9/23/2021 | | | WHC | 0 | LTR | 1 | Kikuchi | Voth | Webb,T | Hicks |
| 9/23/2021 | | | LVB | 13 | JOT | 9 | Stratton | Cabrera,G | Robles,H | Pujols |
| 9/24/2021 | | | CCC | 5 | JER | 2 | Nola,Aa | Allard | Hand | Wallach |
| 9/24/2021 | | | LAH | 13 | COL | 3 | Garcia,D | Quintana | | Dubon |
| 9/24/2021 | | | HOU | 4 | PHS | 5 | Kinley | Minter | Anderson,N | Devers |
| 9/24/2021 | | | SCA | 2 | ISO | 12 | Kim | Turnbull | | Seager,C |
| 9/24/2021 | | | WHC | 0 | LTR | 1 | Peterson,D | Keller,B | Bummer | Vogelbach |
| 9/24/2021 | | | LVB | 3 | JOT | 10 | Bumgarner | Garcia,LH | | Bell |
| 9/25/2021 | | | CCC | 14 | JER | 1 | Ryu | Montas | Diaz,Ed | Lindor |
| 9/25/2021 | | | LAH | 8 | COL | 4 | Woodruff | Lindblom | Hendriks | Ramirez,J |
| 9/25/2021 | | | HOU | 9 | PHS | 4 | Gallen | Giolito | | Tucker,K |
| 9/25/2021 | | 10 | SCA | 1 | ISO | 2 | Andriese | Romo | | Slater |
| 9/25/2021 | | | WHC | 0 | LTR | 5 | Eflin | Plesac | | Nottingham |
| 9/25/2021 | | | LVB | 8 | JOT | 4 | Stratton | Castro,M | | Suarez,E |
| 9/27/2021 | | | COL | 2 | LAH | 5 | Houck | Scherzer | Hendriks | Taylor,C |
| 9/27/2021 | | | ISO | 8 | SCA | 1 | Wainwright | Bubic | | Contreras,WE |
| 9/28/2021 | | | JER | 5 | CCC | 4 | Junis | Richards,G | Parker | Perez,S |
| 9/28/2021 | | | COL | 0 | LAH | 1 | Perez,O | Greinke | Valdez,C | Ramirez,J |
| 9/28/2021 | | 10 | PHS | 3 | HOU | 1 | Kinley | Hahn | Anderson,N | Higashioka |
| 9/28/2021 | | | ISO | 4 | SCA | 10 | Wright | Cobb | | Pollock |
| 9/28/2021 | | 10 | LTR | 5 | WHC | 6 | Holland,G | Webb,T | | Ward |
| 9/28/2021 | | | JOT | 5 | LVB | 1 | Alcantara,Sa | Rogers,Tr | | Bader |
| 9/29/2021 | | 11 | JER | 2 | CCC | 0 | Parker | Diaz,Ed | | Candelario |
| 9/29/2021 | | | COL | 2 | LAH | 4 | Keller,M | Peralta,F | Hendriks | Taylor,C |
| 9/29/2021 | | | PHS | 4 | HOU | 0 | Cody | Buehler | | Berti |
| 9/29/2021 | | | ISO | 3 | SCA | 1 | Darvish | Cole,G | Antone | Seager,C |
| 9/29/2021 | | | LTR | 9 | WHC | 3 | Zimmer,K | Voth | | Garcia,Av |
| 9/29/2021 | | | JOT | 4 | LVB | 2 | Bieber | Stripling | Cabrera,G | Peralta,D |
| 9/30/2021 | | | JER | 1 | CCC | 6 | Lynn | Valdez,F | | Dalbec |
| 9/30/2021 | | | COL | 0 | LAH | 7 | Keuchel | Lindblom | | Cordero,F |
| 9/30/2021 | | 13 | PHS | 4 | HOU | 3 | Anderson,N | Smyly | Guerra,Ju | Reddick |
| 9/30/2021 | | | ISO | 8 | SCA | 3 | Kim | Turnbull | Shreve | Donaldson |
| 9/30/2021 | | | LTR | 1 | WHC | 3 | Keller,B | Lopez,P | Holland,G | Moran,C |
| 9/30/2021 | | | JOT | 11 | LVB | 6 | Reyes,A | Teheran | | Moustakas |