League game results -- National
Regular season
| Results |
| Date | # | Inn | Away | R | Home | R | Win | Loss | Save | GWRBI |
| 4/1/2021 | | | PUR | 2 | GOT | 0 | Hudson,Dak | Gray,S | Jeffress | Belt |
| 4/1/2021 | | 11 | NUT | 4 | CYC | 3 | Dayton | Pressly | | Newman |
| 4/1/2021 | | | ATK | 6 | SMC | 1 | Fried | Berrios | Treinen | Votto |
| 4/1/2021 | | | PAN | 4 | NHH | 5 | Brault | Civale | Quantrill | Barnes,A |
| 4/1/2021 | | | BEA | 1 | PLU | 0 | Bundy | Gibson | | Chapman,M |
| 4/1/2021 | | | SEA | 0 | BOM | 6 | deGrom | Bassitt | Suter | Goldschmidt |
| 4/2/2021 | | 11 | PUR | 1 | GOT | 2 | Hernandez,J | Jeffress | | Gregorius |
| 4/2/2021 | | | NUT | 5 | CYC | 3 | Neris | Strahm | Dayton | Carlson |
| 4/2/2021 | | | ATK | 2 | SMC | 3 | Gonzales | Yarbrough | Melancon | Simmons |
| 4/2/2021 | | | PAN | 1 | NHH | 3 | Barria | Duffy | Quantrill | Stassi |
| 4/2/2021 | | | BEA | 2 | PLU | 1 | Rosenthal | Scott | Jansen,K | Cano |
| 4/2/2021 | | | SEA | 4 | BOM | 6 | Hendricks | Snell | Colome | |
| 4/3/2021 | | | PUR | 8 | GOT | 10 | Familia | Scrubb | Barlow | Smith,Do |
| 4/3/2021 | | | NUT | 5 | CYC | 7 | Tropeano | Javier | Wilson,J | Gurriel,Y |
| 4/3/2021 | | | ATK | 5 | SMC | 7 | Walker,T | Montgomery,J | Matzek | Anderson,Bri |
| 4/3/2021 | | | PAN | 2 | NHH | 4 | Farmer,B | Cordero,J | Quantrill | Reyes,V |
| 4/3/2021 | | | BEA | 2 | PLU | 5 | Glasnow | Lakins | Scott | Moncada |
| 4/3/2021 | | | SEA | 2 | BOM | 4 | Wheeler | Mahle | Colome | Winker |
| 4/4/2021 | | | PAN | 0 | GOT | 1 | Tanaka | Musgrove | Kuhl | Nola,Au |
| 4/4/2021 | | | ATK | 2 | CYC | 0 | Skubal | Garrett,B | Martin,C | |
| 4/4/2021 | | | SEA | 4 | SMC | 2 | Carrasco | Luzardo | Plutko | Upton |
| 4/4/2021 | | | PUR | 1 | PLU | 5 | Bass | Young,Al | | Adell |
| 4/4/2021 | | | NUT | 5 | BOM | 19 | Castillo,D | Fedde | | Story |
| 4/4/2021 | | 10 | BEA | 2 | NHH | 3 | Kolarek | Pomeranz | | Hays |
| 4/5/2021 | | | PAN | 6 | GOT | 1 | Lopez,J | Lester | Watson | Harrison,J |
| 4/5/2021 | | | ATK | 4 | CYC | 6 | Norris | Tomlin | Pressly | Rosario,E |
| 4/5/2021 | | 10 | SEA | 6 | SMC | 5 | Baragar | Melancon | | Goodwin |
| 4/5/2021 | | | PUR | 7 | PLU | 9 | Selman | Young,Al | Garcia,B | Bregman |
| 4/5/2021 | | | NUT | 4 | BOM | 0 | Perez,Ma | Houser | | Calhoun,K |
| 4/5/2021 | | | BEA | 3 | NHH | 1 | Sanchez,An | Ynoa | Jansen,K | Wong |
| 4/6/2021 | | | PAN | 3 | GOT | 7 | Gray,S | Matz | | Smith,Do |
| 4/6/2021 | | | ATK | 4 | CYC | 5 | Heaney | Fried | Alexander,T | Cabrera,M |
| 4/6/2021 | | | SEA | 8 | SMC | 6 | Bassitt | Berrios | Hill,T | Goodwin |
| 4/6/2021 | | 11 | PUR | 7 | PLU | 8 | Garcia,B | Valdez,P | | Adell |
| 4/6/2021 | | | NUT | 0 | BOM | 6 | deGrom | Bauer | | Brantley |
| 4/6/2021 | | 10 | BEA | 8 | NHH | 9 | Smeltzer | Velasquez | | Lewis |
| 4/7/2021 | | | NHH | 1 | GOT | 12 | Kershaw | Barria | | Gregorius |
| 4/7/2021 | | | BEA | 7 | CYC | 3 | Porcello | Means | | Trout |
| 4/7/2021 | | 16 | BOM | 6 | SMC | 5 | Wendelken | Pearson | Castillo,D | Story |
| 4/7/2021 | | | PAN | 18 | PUR | 7 | Watson | Valdez,P | | Robert |
| 4/7/2021 | | | NUT | 3 | PLU | 5 | Gibson | Neris | Scott | Myers |
| 4/7/2021 | | | ATK | 7 | SEA | 3 | Yarbrough | Snell | | Pham |
| 4/8/2021 | | | NHH | 3 | GOT | 4 | Alzolay | Minor | Green | Edman |
| 4/8/2021 | | | BEA | 0 | CYC | 5 | Gonzalez,G | Mize | | Albies |
| 4/8/2021 | | | BOM | 10 | SMC | 1 | Wheeler | Walker,T | | Brantley |
| 4/8/2021 | | | PAN | 2 | PUR | 4 | Canning | Duffy | Scrubb | Grichuk |
| 4/8/2021 | | | NUT | 9 | PLU | 6 | Javier | Davies | Dayton | |
| 4/8/2021 | | | ATK | 7 | SEA | 2 | Montgomery,J | Mahle | | Franco |
| 4/9/2021 | | | NHH | 2 | GOT | 3 | Tanaka | Gray,J | Green | Nunez,R |
| 4/9/2021 | | 11 | BEA | 8 | CYC | 7 | Jansen,K | Hunter | | Trout |
| 4/9/2021 | | | BOM | 5 | SMC | 7 | Luzardo | Urias,J | Loup | Biggio |
| 4/9/2021 | | | PAN | 2 | PUR | 8 | Webb,L | Dunn | | Hernandez,T |
| 4/9/2021 | | | NUT | 3 | PLU | 4 | McKenzie | Fedde | Scott | Torres |
| 4/9/2021 | | | ATK | 7 | SEA | 10 | Carrasco | Skubal | Plutko | Lowe,B |
| 4/11/2021 | | | GOT | 5 | PUR | 1 | Lester | Eshelman | | Pinder |
| 4/11/2021 | | | CYC | 4 | NUT | 8 | Fairbanks | Norris | | Romine,Au |
| 4/11/2021 | | | SMC | 9 | ATK | 8 | Lugo,S | Tomlin | Melancon | Grossman |
| 4/11/2021 | | | NHH | 6 | PAN | 4 | Tepera | Hudson,Dan | Quantrill | Wendle |
| 4/11/2021 | | | PLU | 12 | BEA | 4 | Maeda | Sanchez,An | | Myers |
| 4/11/2021 | | | BOM | 6 | SEA | 2 | Houser | Fleming | | Goldschmidt |
| 4/12/2021 | | 13 | GOT | 3 | PUR | 2 | Green | Young,Al | Kuhl | Aguilar |
| 4/12/2021 | | | CYC | 7 | NUT | 1 | Means | Bauer | Almonte,Y | Castellanos,N |
| 4/12/2021 | | | SMC | 1 | ATK | 5 | Fried | Berrios | | Long |
| 4/12/2021 | | | NHH | 0 | PAN | 6 | Lopez,J | Brault | | Robert |
| 4/12/2021 | | | PLU | 4 | BEA | 3 | Peralta,W | Jansen,K | Garcia,B | Cooper |
| 4/12/2021 | | | BOM | 9 | SEA | 4 | deGrom | Hill,T | | Brantley |
| 4/13/2021 | | | GOT | 11 | PUR | 1 | Kershaw | Freeland | Kuhl | Engel |
| 4/13/2021 | | | CYC | 3 | NUT | 0 | Gonzalez,G | Senzatela | Pressly | Albies |
| 4/13/2021 | | | SMC | 5 | ATK | 7 | Yarbrough | Gonzales | Martin,C | Yastrzemski |
| 4/13/2021 | | | NHH | 4 | PAN | 6 | Watson | Barria | Hudson,Dan | Munoz |
| 4/13/2021 | | | PLU | 5 | BEA | 3 | Gonsolin | Porcello | Scott | Cooper |
| 4/13/2021 | | | BOM | 8 | SEA | 5 | Hendricks | Plutko | | Brosseau |
| 4/14/2021 | | | GOT | 4 | PUR | 3 | Alzolay | Canning | Green | |
| 4/14/2021 | | 10 | CYC | 3 | NUT | 4 | Dayton | Pressly | | Romine,Au |
| 4/14/2021 | | | SMC | 2 | ATK | 5 | Montgomery,J | Walker,T | Martin,C | Yastrzemski |
| 4/14/2021 | | 10 | NHH | 5 | PAN | 4 | Quantrill | Hudson,Dan | | Kipnis |
| 4/14/2021 | | | PLU | 4 | BEA | 9 | Mize | Gibson | | Judge |
| 4/14/2021 | | | BOM | 3 | SEA | 1 | Wheeler | Mahle | Colome | Winker |
| 4/15/2021 | | | GOT | 3 | ATK | 4 | Lorenzen | Tanaka | Martin,C | Votto |
| 4/15/2021 | | | CYC | 8 | BEA | 5 | Norris | Paddack | Beeks | Cabrera,M |
| 4/15/2021 | | 10 | SMC | 4 | BOM | 3 | Matzek | Colome | Melancon | Riley |
| 4/15/2021 | | 20 | PUR | 5 | PAN | 3 | Ray | Patino | | Gurriel,L |
| 4/15/2021 | | | PLU | 5 | NHH | 3 | Davies | Gray,J | Scott | Torres |
| 4/15/2021 | | | SEA | 11 | NUT | 3 | Carrasco | Fedde | Plutko | Lowe,B |
| 4/16/2021 | | | GOT | 1 | ATK | 4 | Tomlin | Lester | Karinchak | Franco |
| 4/16/2021 | | | CYC | 5 | BEA | 6 | Rosenthal | Beeks | | |
| 4/16/2021 | | | SMC | 5 | BOM | 2 | Anderson,I | Houser | Melancon | Biggio |
| 4/16/2021 | | | PUR | 4 | PAN | 2 | Eshelman | Dunn | Finnegan | Belt |
| 4/16/2021 | | | PLU | 3 | NHH | 11 | Ynoa | Glasnow | | Urshela |
| 4/16/2021 | | | SEA | 6 | NUT | 3 | Fleming | Perez,Ma | Kintzler | Lowe,B |
| 4/17/2021 | | | GOT | 15 | ATK | 1 | Gray,S | Fried | Smith,C | Smith,Do |
| 4/17/2021 | | | CYC | 2 | BEA | 6 | Bundy | Means | Jansen,K | Harper,B |
| 4/17/2021 | | 11 | SMC | 2 | BOM | 3 | Tate | Loup | | Story |
| 4/17/2021 | | | PUR | 1 | PAN | 4 | Musgrove | Hudson,Dak | Turley | |
| 4/17/2021 | | | PLU | 1 | NHH | 2 | Tepera | Maeda | Quantrill | Reyes,V |
| 4/17/2021 | | | SEA | 2 | NUT | 5 | Bauer | Bassitt | Dayton | Carlson |
| 4/18/2021 | | | GOT | 7 | PLU | 0 | Kershaw | Sanchez,S | | Nunez,R |
| 4/18/2021 | | 10 | SMC | 6 | CYC | 4 | May,T | Beeks | | |
| 4/18/2021 | | | BOM | 4 | PAN | 1 | Hendricks | Lopez,J | Tate | Marte,S |
| 4/18/2021 | | | SEA | 0 | NHH | 8 | Barria | Snell | Allen,L | Frazier,T |
| 4/18/2021 | | | NUT | 7 | ATK | 13 | Yarbrough | Senzatela | | Votto |
| 4/18/2021 | | | BEA | 15 | PUR | 6 | Porcello | Freeland | | Harper,B |
| 4/19/2021 | | | GOT | 4 | PLU | 2 | Alzolay | Gonsolin | Green | Laureano |
| 4/19/2021 | | | SMC | 6 | CYC | 8 | Hunter | Greene | Pressly | Bradley,J |
| 4/19/2021 | | | BOM | 7 | PAN | 0 | Wheeler | Matz | | LeMahieu |
| 4/19/2021 | | | SEA | 4 | NHH | 1 | Mahle | Minor | Kintzler | Moore |
| 4/19/2021 | | | NUT | 2 | ATK | 1 | Javier | Montgomery,J | Dayton | Iglesias,J |
| 4/19/2021 | | | BEA | 6 | PUR | 7 | Finnegan | Jansen,K | | Hernandez,T |
| 4/20/2021 | | | GOT | 7 | PLU | 13 | Garcia,Ja | Tanaka | | Adell |
| 4/20/2021 | | 12 | SMC | 5 | CYC | 3 | Melancon | Tropeano | Matzek | Abreu,J |
| 4/20/2021 | | | BOM | 4 | PAN | 0 | Urias,J | Civale | | Schoop |
| 4/20/2021 | | | SEA | 7 | NHH | 9 | Allen,L | Carrasco | Quantrill | Wendle |
| 4/20/2021 | | | NUT | 7 | ATK | 3 | Fedde | Skubal | | Robles,V |
| 4/20/2021 | | | BEA | 2 | PUR | 3 | Scrubb | Jansen,K | | Gurriel,L |
| 4/21/2021 | | | GOT | 5 | NHH | 4 | Lester | Ynoa | Green | Smith,Do |
| 4/21/2021 | | | BOM | 5 | CYC | 2 | Houser | Heaney | Colome | Story |
| 4/21/2021 | | | SMC | 5 | PUR | 2 | Anderson,I | Eshelman | Melancon | Riley |
| 4/21/2021 | | | BEA | 4 | PAN | 0 | Sanchez,An | Duffy | | Trout |
| 4/21/2021 | | 15 | PLU | 4 | NUT | 2 | Garcia,Ja | Clarke | McKenzie | Torres |
| 4/21/2021 | | | SEA | 4 | ATK | 0 | Fleming | Tomlin | | Lowe,B |
| 4/22/2021 | | | GOT | 3 | NHH | 6 | Brault | Gray,S | Quantrill | Conforto |
| 4/22/2021 | | | BOM | 7 | CYC | 3 | deGrom | Means | | Davis,K |
| 4/22/2021 | | | SMC | 4 | PUR | 1 | Greene | Young,Al | | Anderson,Bri |
| 4/22/2021 | | | BEA | 4 | PAN | 0 | Bundy | Dunn | | Trout |
| 4/22/2021 | | | PLU | 5 | NUT | 9 | Bauer | Glasnow | | Iglesias,J |
| 4/22/2021 | | | SEA | 5 | ATK | 2 | Bassitt | Fried | Kintzler | Upton |
| 4/23/2021 | | | GOT | 7 | NHH | 5 | Kershaw | Allen,L | Barlow | Edman |
| 4/23/2021 | | | BOM | 9 | CYC | 6 | Hendricks | Beeks | Colome | Goldschmidt |
| 4/23/2021 | | | SMC | 3 | PUR | 1 | Matzek | Freeland | Loup | Simmons |
| 4/23/2021 | | 11 | BEA | 8 | PAN | 5 | Fry,P | Hudson,Dan | Velasquez | Tejeda |
| 4/23/2021 | | | PLU | 11 | NUT | 12 | Neris | Rodon | Dayton | Iglesias,J |
| 4/23/2021 | | | SEA | 2 | ATK | 3 | Yarbrough | Snell | Martin,C | Valaika |
| 4/25/2021 | | | ATK | 0 | GOT | 7 | Alzolay | Montgomery,J | Margevicius | |
| 4/25/2021 | | | CYC | 3 | SMC | 10 | Lugo,S | Garrett,B | | Anderson,Bri |
| 4/25/2021 | | | PAN | 1 | BOM | 3 | Wheeler | Watson | Colome | Story |
| 4/25/2021 | | 10 | NHH | 4 | PLU | 5 | Garcia,B | Farmer,B | | Adell |
| 4/25/2021 | | | NUT | 0 | SEA | 3 | Mahle | Javier | Kintzler | Moore |
| 4/25/2021 | | | PUR | 1 | BEA | 5 | Mize | Canning | Rosenthal | Cano |
| 4/26/2021 | | | ATK | 3 | GOT | 4 | Hernandez,J | Williams,D | Green | Smith,Do |
| 4/26/2021 | | | CYC | 8 | SMC | 11 | Luzardo | Heaney | | Abreu,J |
| 4/26/2021 | | | PAN | 2 | BOM | 11 | Urias,J | Matz | | LeMahieu |
| 4/26/2021 | | | NHH | 3 | PLU | 2 | Gray,J | Gonsolin | Quantrill | Wendle |
| 4/26/2021 | | | NUT | 6 | SEA | 0 | Fedde | Carrasco | | Calhoun,K |
| 4/26/2021 | | | PUR | 0 | BEA | 12 | Paddack | Webb,L | | Harper,B |
| 4/27/2021 | | | ATK | 4 | GOT | 9 | Lester | Tomlin | Barlow | Kepler |
| 4/27/2021 | | | CYC | 1 | SMC | 3 | Anderson,I | Means | Melancon | Anderson,Bri |
| 4/27/2021 | | | PAN | 4 | BOM | 5 | Hader | Cordero,J | Colome | Goldschmidt |
| 4/27/2021 | | | NHH | 7 | PLU | 4 | Tepera | Gibson | Quantrill | Urshela |
| 4/27/2021 | | 13 | NUT | 7 | SEA | 6 | Clarke | Baragar | | Calhoun,K |
| 4/27/2021 | | | PUR | 8 | BEA | 4 | Young,Al | Jansen,K | | Gurriel,L |
| 4/28/2021 | | | PLU | 8 | GOT | 0 | Davies | Gray,S | | Odor |
| 4/28/2021 | | | CYC | 3 | BOM | 10 | deGrom | Gonzalez,G | | Goldschmidt |
| 4/28/2021 | | | PUR | 0 | SMC | 8 | Berrios | Scrubb | | Biggio |
| 4/28/2021 | | 12 | PAN | 9 | BEA | 10 | Lakins | Wick | | Cron,CJ |
| 4/28/2021 | | | NHH | 7 | SEA | 8 | Kintzler | Allen,L | Stammen | Upton |
| 4/28/2021 | | | ATK | 2 | NUT | 4 | Bauer | Fried | Neris | Gallo |
| 4/29/2021 | | 13 | PLU | 4 | GOT | 5 | Hernandez,J | McKenzie | | Arenado |
| 4/29/2021 | | | CYC | 2 | BOM | 11 | Hendricks | Norris | | Brosseau |
| 4/29/2021 | | | PUR | 4 | SMC | 1 | Freeland | Gonzales | Jeffress | Hernandez,T |
| 4/29/2021 | | | PAN | 3 | BEA | 4 | Porcello | Dunn | Velasquez | Trout |
| 4/29/2021 | | 10 | NHH | 7 | SEA | 5 | Allen,L | Baragar | Quantrill | Stassi |
| 4/29/2021 | | | ATK | 3 | NUT | 17 | Senzatela | Yarbrough | | Bohm |
| 4/30/2021 | | | PLU | 0 | GOT | 7 | Alzolay | Maeda | | Nunez,R |
| 4/30/2021 | | | CYC | 3 | BOM | 9 | Wheeler | Garrett,B | | Dickerson,A |
| 4/30/2021 | | | PUR | 3 | SMC | 8 | Lugo,S | Canning | Greene | Grossman |
| 4/30/2021 | | | PAN | 4 | BEA | 11 | Mize | Musgrove | Rosenthal | Judge |
| 4/30/2021 | | | NHH | 4 | SEA | 8 | Mahle | Minor | | Encarnacion |
| 4/30/2021 | | | ATK | 2 | NUT | 3 | Crichton | Montgomery,J | Fairbanks | |
| 5/1/2021 | | | GOT | 2 | CYC | 3 | Wilson,J | Garrett,A | Pressly | Castellanos,N |
| 5/1/2021 | | | NHH | 9 | SMC | 5 | Gray,J | Luzardo | | Conforto |
| 5/1/2021 | | | ATK | 3 | PAN | 4 | Turley | Skubal | Patino | Kiner-Falefa |
| 5/1/2021 | | | PLU | 4 | BOM | 5 | Hill,C | Sanchez,S | Colome | Marte,S |
| 5/1/2021 | | | SEA | 2 | BEA | 3 | Fry,P | Plutko | | Tejeda |
| 5/1/2021 | | | NUT | 4 | PUR | 11 | Webb,L | Fedde | Young,Al | Hernandez,T |
| 5/2/2021 | | | GOT | 4 | CYC | 8 | Means | Lester | | Bradley,J |
| 5/2/2021 | | 12 | NHH | 4 | SMC | 3 | Quantrill | Matzek | Tepera | Margot |
| 5/2/2021 | | 11 | ATK | 6 | PAN | 5 | Karinchak | Patino | Martin,C | Valaika |
| 5/2/2021 | | | PLU | 5 | BOM | 15 | Bedrosian | Gonsolin | | LeMahieu |
| 5/2/2021 | | | SEA | 7 | BEA | 9 | King,M | Hill,T | Jansen,K | Tejeda |
| 5/2/2021 | | | NUT | 6 | PUR | 1 | Perez,Ma | Eshelman | | Calhoun,K |
| 5/3/2021 | | | GOT | 6 | CYC | 5 | Familia | Gonzalez,G | Barlow | Caratini |
| 5/3/2021 | | | NHH | 0 | SMC | 3 | Berrios | Brault | Matzek | |
| 5/3/2021 | | | ATK | 0 | PAN | 2 | Civale | Fried | | Rosario,A |
| 5/3/2021 | | | PLU | 3 | BOM | 10 | deGrom | Gibson | | LeMahieu |
| 5/3/2021 | | | SEA | 2 | BEA | 5 | Bundy | Bassitt | Rosenthal | Judge |
| 5/3/2021 | | | NUT | 4 | PUR | 2 | Bauer | Hudson,Dak | Dayton | Gimenez |
| 5/4/2021 | | | JER | 0 | NUT | 3 | Senzatela | Valdez,F | Dayton | Gallo |
| 5/4/2021 | | | LAH | 5 | NHH | 6 | Smeltzer | Dolis | Quantrill | Lewis |
| 5/4/2021 | | | HOU | 5 | BOM | 11 | Hendricks | Burnes | | Winker |
| 5/4/2021 | | | SCA | 3 | SMC | 7 | Gonzales | Turnbull | | Riley |
| 5/4/2021 | | | CCC | 7 | SEA | 6 | Cisnero | Bard,D | Diaz,Ed | Rizzo |
| 5/4/2021 | | | ISO | 0 | ATK | 8 | Yarbrough | Kim | | Yastrzemski |
| 5/4/2021 | | | LTR | 3 | GOT | 4 | Baez,P | Lopez,P | Green | Grisham |
| 5/4/2021 | | | PHS | 4 | CYC | 5 | Norris | Pena | Pressly | Gyorko |
| 5/4/2021 | | | WHC | 2 | PLU | 10 | Davies | Sheffield | | Mejia,F |
| 5/4/2021 | | | JOT | 3 | BEA | 4 | Pomeranz | Morejon | Jansen,K | Wong |
| 5/4/2021 | | | COL | 1 | PAN | 11 | Duffy | Quintana | | |
| 5/4/2021 | | | LVB | 2 | PUR | 15 | Freeland | Teheran | | Severino |
| 5/5/2021 | | | JER | 13 | NUT | 2 | Roark | Javier | | Happ,I |
| 5/5/2021 | | | LAH | 19 | NHH | 11 | Smith,B | Allen,L | Ramirez,E | Ramirez,J |
| 5/5/2021 | | 15 | HOU | 2 | BOM | 3 | Tate | Foster | | Goldschmidt |
| 5/5/2021 | | | SCA | 12 | SMC | 8 | Romo | Ramirez,No | | Yelich |
| 5/5/2021 | | | CCC | 16 | SEA | 2 | Nola,Aa | Mahle | | Cruz,N |
| 5/5/2021 | | | ISO | 2 | ATK | 4 | Montgomery,J | Clevinger | Martin,C | Long |
| 5/5/2021 | | | LTR | 5 | GOT | 9 | Alzolay | Fiers | | Smith,Do |
| 5/5/2021 | | | PHS | 8 | CYC | 4 | Brubaker | Garrett,B | | Higashioka |
| 5/5/2021 | | | WHC | 10 | PLU | 1 | Holland,G | Glasnow | | Grandal |
| 5/5/2021 | | 10 | JOT | 8 | BEA | 10 | Rosenthal | Alcala | | Smith,WD |
| 5/5/2021 | | | COL | 4 | PAN | 0 | Peralta,F | Dunn | Gant | Adames |
| 5/5/2021 | | | LVB | 3 | PUR | 5 | Jeffress | Stratton | | Severino |
| 5/6/2021 | | | JER | 4 | NUT | 0 | Montas | Fedde | Iglesias,R | Reynolds,B |
| 5/6/2021 | | | LAH | 10 | NHH | 7 | Paredes,E | Quantrill | Hendriks | Taylor,C |
| 5/6/2021 | | | HOU | 6 | BOM | 4 | Gallen | Urias,J | Smith,R | McBroom |
| 5/6/2021 | | | SCA | 3 | SMC | 2 | Clippard | Matzek | Rogers,Ta | Bellinger |
| 5/6/2021 | | 10 | CCC | 3 | SEA | 4 | Hill,T | Diaz,Ed | | Ruiz,R |
| 5/6/2021 | | | ISO | 8 | ATK | 2 | Wainwright | Skubal | | Pederson |
| 5/6/2021 | | | LTR | 5 | GOT | 6 | Garrett,A | Webb,T | Green | Gregorius |
| 5/6/2021 | | | PHS | 2 | CYC | 5 | Heaney | Giolito | Pressly | Albies |
| 5/6/2021 | | | WHC | 9 | PLU | 5 | Suero | Garcia,B | | Ward |
| 5/6/2021 | | | JOT | 0 | BEA | 4 | Paddack | Flaherty | | Tejeda |
| 5/6/2021 | | | COL | 0 | PAN | 7 | Musgrove | Greinke | Heuer | Rosario,A |
| 5/6/2021 | | | LVB | 4 | PUR | 0 | Akin | Webb,L | Garcia,LH | |
| 5/8/2021 | | | NUT | 7 | JER | 9 | Britton | Perez,Ma | Iglesias,R | Perez,S |
| 5/8/2021 | | 10 | NHH | 5 | LAH | 6 | Hendriks | Smeltzer | | Turner,T |
| 5/8/2021 | | | BOM | 4 | HOU | 10 | Gausman | Houser | | Machado |
| 5/8/2021 | | | SMC | 5 | SCA | 0 | Anderson,I | Wright | | Riley |
| 5/8/2021 | | | SEA | 1 | CCC | 4 | Marquez,G | Fleming | Hand | Hernandez,Ce |
| 5/8/2021 | | | ATK | 7 | ISO | 2 | Tomlin | Cobb | | Markakis |
| 5/8/2021 | | | GOT | 2 | LTR | 7 | Peterson,D | Lester | | Soto,J |
| 5/8/2021 | | | CYC | 1 | PHS | 2 | Rainey | Almonte,Y | Anderson,N | Schwarber |
| 5/8/2021 | | | PLU | 5 | WHC | 4 | Garcia,Ja | Plesac | Garcia,B | |
| 5/8/2021 | | | BEA | 9 | JOT | 6 | Fry,P | Alcantara,Sa | Jansen,K | Smith,WD |
| 5/8/2021 | | | PAN | 2 | COL | 13 | Scherzer | Lopez,J | | |
| 5/8/2021 | | | PUR | 5 | LVB | 2 | Eshelman | Anderson,Ty | Jeffress | La Stella |
| 5/9/2021 | | | NUT | 6 | JER | 18 | Singer | Bauer | Gonzalez,V | Happ,I |
| 5/9/2021 | | | NHH | 2 | LAH | 1 | Brault | Garcia,D | Smeltzer | Guzman,R |
| 5/9/2021 | | 10 | BOM | 6 | HOU | 3 | Castillo,D | Smyly | Colome | LeMahieu |
| 5/9/2021 | | | SMC | 4 | SCA | 12 | Cole,G | Berrios | Clippard | Guerrero |
| 5/9/2021 | | | SEA | 6 | CCC | 5 | Bassitt | Lynn | Plutko | Ruiz,R |
| 5/9/2021 | | | ATK | 1 | ISO | 4 | Darvish | Fried | Antone | Freeman,F |
| 5/9/2021 | | | GOT | 5 | LTR | 3 | Gray,S | Eflin | Green | Smith,Do |
| 5/9/2021 | | | CYC | 5 | PHS | 8 | Cahill | Norris | | Joyce |
| 5/9/2021 | | | PLU | 5 | WHC | 0 | Gonsolin | Sheffield | | Marte,K |
| 5/9/2021 | | | BEA | 2 | JOT | 4 | Bieber | Bundy | Castro,M | Peralta,D |
| 5/9/2021 | | | PAN | 3 | COL | 4 | Lindblom | Matz | Gant | Adames |
| 5/9/2021 | | | PUR | 7 | LVB | 3 | Hudson,Dak | Castellani | | Severino |
| 5/10/2021 | | | NUT | 1 | JER | 3 | Valdez,F | Senzatela | Iglesias,R | Candelario |
| 5/10/2021 | | | NHH | 3 | LAH | 4 | Thielbar | Kolarek | | Voit |
| 5/10/2021 | | | BOM | 2 | HOU | 4 | Burnes | Hendricks | Hahn | Tatis |
| 5/10/2021 | | | SMC | 8 | SCA | 4 | Gonzales | Buttrey | Matzek | Riley |
| 5/10/2021 | | | SEA | 3 | CCC | 4 | Miller,A | Baragar | Hand | Rizzo |
| 5/10/2021 | | | ATK | 3 | ISO | 7 | Kim | Yarbrough | Andriese | |
| 5/10/2021 | | | GOT | 10 | LTR | 6 | Kershaw | Dobnak | | Kepler |
| 5/10/2021 | | | CYC | 6 | PHS | 7 | Merryweather | Pressly | | Solano |
| 5/10/2021 | | | PLU | 6 | WHC | 4 | Gibson | Voth | | Bregman |
| 5/10/2021 | | | BEA | 3 | JOT | 0 | Porcello | McCullers | Jansen,K | Cano |
| 5/10/2021 | | | PAN | 2 | COL | 6 | Peralta,F | Civale | Pagan | Turner,J |
| 5/10/2021 | | | PUR | 4 | LVB | 6 | Stratton | Staumont | | Kieboom |
| 5/11/2021 | | | CYC | 0 | GOT | 7 | Alzolay | Heaney | | Aguilar |
| 5/11/2021 | | | SMC | 4 | NHH | 2 | Matzek | Quantrill | Melancon | Simmons |
| 5/11/2021 | | | PAN | 1 | ATK | 3 | Montgomery,J | Watson | Martin,C | Yastrzemski |
| 5/11/2021 | | | BOM | 11 | PLU | 1 | Wheeler | Davies | | LeMahieu |
| 5/11/2021 | | | BEA | 5 | SEA | 7 | Plutko | Rosenthal | Hill,T | Moore |
| 5/11/2021 | | | PUR | 2 | NUT | 7 | Crichton | Canning | Dayton | Fletcher,D |
| 5/12/2021 | | | CYC | 5 | GOT | 3 | Gonzalez,G | Tanaka | Wilson,J | Bradley,J |
| 5/12/2021 | | | SMC | 4 | NHH | 0 | Luzardo | Gray,J | | Kendrick |
| 5/12/2021 | | | PAN | 3 | ATK | 2 | Heuer | Karinchak | Hudson,Dan | Harrison,J |
| 5/12/2021 | | | BOM | 6 | PLU | 4 | Urias,J | Glasnow | Colome | Marte,S |
| 5/12/2021 | | | BEA | 3 | SEA | 5 | Hill,T | Rosenthal | | Lowe,B |
| 5/12/2021 | | | PUR | 8 | NUT | 4 | Webb,L | Fedde | | Belt |
| 5/13/2021 | | | CYC | 7 | GOT | 8 | Kuhl | Hunter | Green | Caratini |
| 5/13/2021 | | 10 | SMC | 5 | NHH | 2 | Greene | Quantrill | Melancon | d'Arnaud |
| 5/13/2021 | | | PAN | 1 | ATK | 5 | Tomlin | Turley | | Long |
| 5/13/2021 | | | BOM | 7 | PLU | 4 | Houser | Maeda | Colome | Story |
| 5/13/2021 | | | BEA | 4 | SEA | 14 | Fleming | Sanchez,An | Kintzler | Lowe,B |
| 5/13/2021 | | | PUR | 4 | NUT | 2 | Eshelman | Perez,Ma | Jeffress | Garver |
| 5/14/2021 | | | CYC | 3 | GOT | 10 | Gray,S | Norris | | Aguilar |
| 5/14/2021 | | | SMC | 3 | NHH | 4 | Kolarek | Greene | | Conforto |
| 5/14/2021 | | | PAN | 1 | ATK | 2 | Fried | Lopez,J | Martin,C | Markakis |
| 5/14/2021 | | | BOM | 9 | PLU | 2 | deGrom | Sanchez,S | | Winker |
| 5/14/2021 | | | BEA | 8 | SEA | 6 | Bundy | Bassitt | | Cano |
| 5/14/2021 | | | PUR | 1 | NUT | 4 | Bauer | Hudson,Dak | Dayton | Calhoun,K |
| 5/16/2021 | | | GOT | 10 | SEA | 2 | Kershaw | Snell | | Smith,Do |
| 5/16/2021 | | | CYC | 4 | PAN | 8 | Matz | Heaney | | White,Ev |
| 5/16/2021 | | | BEA | 1 | SMC | 7 | Gonzales | Porcello | | Abreu,J |
| 5/16/2021 | | | PLU | 2 | ATK | 5 | Williams,D | Peralta,W | Martin,C | McCann |
| 5/16/2021 | | | BOM | 12 | PUR | 4 | Hendricks | Freeland | | Brosseau |
| 5/16/2021 | | | NHH | 11 | NUT | 3 | Barria | Crichton | Allen,L | |
| 5/17/2021 | | | GOT | 3 | SEA | 4 | Mahle | Alzolay | Kintzler | Encarnacion |
| 5/17/2021 | | | CYC | 6 | PAN | 1 | Gonzalez,G | Civale | | Cabrera,M |
| 5/17/2021 | | | BEA | 8 | SMC | 9 | Ramirez,No | Pomeranz | | Plawecki |
| 5/17/2021 | | | PLU | 3 | ATK | 4 | Treinen | Garcia,Ja | | Votto |
| 5/17/2021 | | | BOM | 5 | PUR | 2 | Wheeler | Canning | Colome | LeMahieu |
| 5/17/2021 | | | NHH | 4 | NUT | 6 | Dayton | Tepera | | Calhoun,K |
| 5/18/2021 | | | GOT | 6 | SEA | 4 | Tanaka | Carrasco | Green | Nola,Au |
| 5/18/2021 | | | CYC | 5 | PAN | 1 | Means | Duffy | Pressly | Ahmed |
| 5/18/2021 | | | BEA | 3 | SMC | 7 | Luzardo | Paddack | | Biggio |
| 5/18/2021 | | | PLU | 4 | ATK | 3 | Davies | Skubal | Scott | |
| 5/18/2021 | | | BOM | 17 | PUR | 1 | Urias,J | Webb,L | Suter | LeMahieu |
| 5/18/2021 | | | NHH | 5 | NUT | 3 | Kolarek | Dayton | Quantrill | Lewis |
| 5/19/2021 | | 10 | PAN | 1 | GOT | 2 | Green | Watson | | Grisham |
| 5/19/2021 | | 12 | CYC | 11 | ATK | 7 | Norris | Graterol | | Castellanos,N |
| 5/19/2021 | | | SMC | 4 | SEA | 1 | Anderson,I | Fleming | Melancon | Biggio |
| 5/19/2021 | | | PLU | 6 | PUR | 3 | Zuber | Eshelman | Scott | Myers |
| 5/19/2021 | | | BOM | 21 | NUT | 7 | Houser | Perez,Ma | | LeMahieu |
| 5/19/2021 | | | BEA | 14 | NHH | 2 | Sanchez,An | Ynoa | | Harper,B |
| 5/20/2021 | | | PAN | 3 | GOT | 1 | Musgrove | Familia | Hudson,Dan | Tapia,R |
| 5/20/2021 | | | CYC | 3 | ATK | 9 | Fried | Norris | McGee | Solak |
| 5/20/2021 | | | SMC | 11 | SEA | 6 | Loup | Bassitt | | Anderson,Bri |
| 5/20/2021 | | | PLU | 3 | PUR | 1 | Maeda | Hudson,Dak | Scott | Cooper |
| 5/20/2021 | | | BOM | 7 | NUT | 4 | deGrom | Bauer | Colome | Winker |
| 5/20/2021 | | | BEA | 9 | NHH | 6 | Bundy | Allen,L | Jansen,K | McCutchen |
| 5/21/2021 | | | PAN | 2 | GOT | 3 | Kershaw | Lopez,J | Green | Smith,Do |
| 5/21/2021 | | | CYC | 3 | ATK | 1 | Heaney | Yarbrough | Strahm | Gurriel,Y |
| 5/21/2021 | | | SMC | 3 | SEA | 7 | Snell | Gonzales | Baragar | Upton |
| 5/21/2021 | | | PLU | 4 | PUR | 1 | Sanchez,S | Freeland | Peralta,W | Marte,K |
| 5/21/2021 | | | BOM | 6 | NUT | 3 | Hendricks | Neris | Wendelken | Schoop |
| 5/21/2021 | | | BEA | 5 | NHH | 13 | Barria | Porcello | | Conforto |
| 5/22/2021 | | | BEA | 8 | GOT | 7 | Thompson | Alzolay | | Cano |
| 5/22/2021 | | | CYC | 1 | SEA | 4 | Mahle | Gonzalez,G | Bard,D | Lowe,B |
| 5/22/2021 | | 12 | SMC | 3 | NUT | 4 | Crichton | Melancon | | |
| 5/22/2021 | | | PLU | 7 | PAN | 2 | Gonsolin | Matz | | Dickerson,C |
| 5/22/2021 | | 12 | BOM | 5 | ATK | 3 | Colome | McGee | | Winker |
| 5/22/2021 | | | PUR | 3 | NHH | 5 | Minor | Canning | Quantrill | Conforto |
| 5/23/2021 | | | BEA | 3 | GOT | 8 | Tanaka | Paddack | Baez,P | Grisham |
| 5/23/2021 | | | CYC | 0 | SEA | 2 | Carrasco | Means | Kintzler | Braun |
| 5/23/2021 | | | SMC | 2 | NUT | 5 | Yardley | Luzardo | Clarke | Calhoun,K |
| 5/23/2021 | | | PLU | 1 | PAN | 5 | Civale | Gibson | | Robert |
| 5/23/2021 | | | BOM | 6 | ATK | 5 | Urias,J | Skubal | Romano,J | Davis,K |
| 5/23/2021 | | | PUR | 7 | NHH | 2 | Brasier | Kolarek | | Grichuk |
| 5/24/2021 | | | BEA | 4 | GOT | 12 | Lester | Sanchez,An | | Kepler |
| 5/24/2021 | | | CYC | 4 | SEA | 3 | Hunter | Hill,T | Pressly | Gurriel,Y |
| 5/24/2021 | | | SMC | 4 | NUT | 12 | Perez,Ma | Anderson,I | | Gimenez |
| 5/24/2021 | | | PLU | 2 | PAN | 4 | Duffy | Davies | Hudson,Dan | Munoz |
| 5/24/2021 | | | BOM | 5 | ATK | 3 | Houser | Tomlin | Castillo,D | Marte,S |
| 5/24/2021 | | | PUR | 5 | NHH | 3 | Eshelman | Ynoa | Jeffress | Grichuk |
| 5/26/2021 | | | GOT | 4 | PAN | 3 | Gray,S | Turley | Green | Edman |
| 5/26/2021 | | 11 | ATK | 7 | CYC | 4 | Williams,D | Wilson,J | | |
| 5/26/2021 | | | SEA | 7 | SMC | 1 | Bassitt | Berrios | | Goodwin |
| 5/26/2021 | | | PUR | 5 | PLU | 1 | Hudson,Dak | Glasnow | | Davis,JD |
| 5/26/2021 | | | NUT | 2 | BOM | 6 | deGrom | Bauer | | Winker |
| 5/26/2021 | | | NHH | 1 | BEA | 4 | Bundy | Allen,L | Jansen,K | Smith,WD |
| 5/27/2021 | | | GOT | 5 | PAN | 2 | Kershaw | Musgrove | Green | Pinder |
| 5/27/2021 | | | ATK | 13 | CYC | 9 | Lorenzen | Gonzalez,G | | Solak |
| 5/27/2021 | | | SEA | 4 | SMC | 8 | Gonzales | Snell | | Abreu,J |
| 5/27/2021 | | | PUR | 6 | PLU | 2 | Freeland | Maeda | Jeffress | Hernandez,T |
| 5/27/2021 | | | NUT | 3 | BOM | 5 | Hendricks | Senzatela | Colome | Schoop |
| 5/27/2021 | | | NHH | 2 | BEA | 7 | Porcello | Barria | Pomeranz | Cano |
| 5/28/2021 | | | GOT | 10 | PAN | 3 | Alzolay | Lopez,J | | Smith,Do |
| 5/28/2021 | | 10 | ATK | 4 | CYC | 2 | Martin,C | Hunter | | Barnhart |
| 5/28/2021 | | | SEA | 5 | SMC | 6 | Walker,T | Mahle | Ramirez,No | Anderson,Bri |
| 5/28/2021 | | | PUR | 4 | PLU | 1 | Canning | Sanchez,S | Jeffress | Sogard |
| 5/28/2021 | | 15 | NUT | 1 | BOM | 2 | Castillo,D | Clarke | | Marte,S |
| 5/28/2021 | | | NHH | 3 | BEA | 2 | Allen,L | Jansen,K | Quantrill | Kipnis |
| 5/29/2021 | | | GOT | 2 | BEA | 3 | Paddack | Tanaka | Jansen,K | Judge |
| 5/29/2021 | | | SEA | 15 | CYC | 9 | Plutko | Gonzalez,G | | Moore |
| 5/29/2021 | | | NUT | 8 | SMC | 2 | Fedde | Luzardo | | Fletcher,D |
| 5/29/2021 | | | PAN | 2 | PLU | 3 | Garcia,Ja | Hudson,Dan | | Myers |
| 5/29/2021 | | | ATK | 1 | BOM | 5 | Urias,J | Skubal | | Goldschmidt |
| 5/29/2021 | | | NHH | 10 | PUR | 3 | Gray,J | Webb,L | | Conforto |
| 5/30/2021 | | | GOT | 4 | BEA | 5 | Sanchez,An | Lester | Velasquez | Flores,W |
| 5/30/2021 | | | SEA | 2 | CYC | 10 | Beeks | Fleming | | Gonzalez,E |
| 5/30/2021 | | | NUT | 2 | SMC | 3 | Anderson,I | Perez,Ma | Greene | Calhoun,W |
| 5/30/2021 | | | PAN | 0 | PLU | 3 | Gibson | Civale | | Myers |
| 5/30/2021 | | 10 | ATK | 4 | BOM | 5 | Tate | Martin,C | | LeMahieu |
| 5/30/2021 | | 10 | NHH | 9 | PUR | 7 | Quantrill | Brasier | | Urshela |
| 5/31/2021 | | | GOT | 2 | BEA | 3 | Bundy | Gray,S | Fry,P | Trout |
| 5/31/2021 | | | SEA | 5 | CYC | 4 | Bassitt | Wilson,J | Hill,T | Lowe,B |
| 5/31/2021 | | | NUT | 13 | SMC | 6 | Fairbanks | Melancon | Dayton | Calhoun,K |
| 5/31/2021 | | | PAN | 3 | PLU | 4 | Davies | Duffy | Scott | Moncada |
| 5/31/2021 | | 10 | ATK | 4 | BOM | 5 | Romano,J | Lorenzen | | Castro,J |
| 5/31/2021 | | | NHH | 3 | PUR | 2 | Brault | Hudson,Dak | Quantrill | Lewis |
| 6/1/2021 | | | NUT | 4 | GOT | 7 | Kershaw | Senzatela | Green | Edman |
| 6/1/2021 | | | PUR | 6 | CYC | 7 | Beeks | Young,Al | | Casali |
| 6/1/2021 | | 12 | PAN | 3 | SMC | 2 | Heuer | Loup | Hudson,Dan | Kiner-Falefa |
| 6/1/2021 | | | SEA | 9 | PLU | 7 | Kintzler | Glasnow | Stammen | Encarnacion |
| 6/1/2021 | | | ATK | 1 | NHH | 4 | Barria | Yarbrough | Quantrill | Bote |
| 6/1/2021 | | | BEA | 3 | BOM | 6 | Hendricks | Porcello | Suter | Brantley |
| 6/2/2021 | | | NUT | 3 | GOT | 7 | Alzolay | Javier | | Grisham |
| 6/2/2021 | | | PUR | 0 | CYC | 3 | Means | Canning | Strahm | Bradley,J |
| 6/2/2021 | | | PAN | 7 | SMC | 2 | Turley | Loup | | Beaty |
| 6/2/2021 | | | SEA | 4 | PLU | 0 | Mahle | Maeda | Kintzler | Hosmer |
| 6/2/2021 | | | ATK | 5 | NHH | 3 | Montgomery,J | Minor | Martin,C | Yastrzemski |
| 6/2/2021 | | | BEA | 10 | BOM | 4 | Mize | Wheeler | | Cano |
| 6/3/2021 | | | NUT | 2 | GOT | 7 | Tanaka | Fedde | | Kepler |
| 6/3/2021 | | | PUR | 6 | CYC | 8 | Wilson,J | Young,Al | | Gyorko |
| 6/3/2021 | | | PAN | 5 | SMC | 3 | Lopez,J | Luzardo | Hudson,Dan | Kiner-Falefa |
| 6/3/2021 | | | SEA | 11 | PLU | 3 | Carrasco | Sanchez,S | | Encarnacion |
| 6/3/2021 | | | ATK | 4 | NHH | 10 | Gray,J | Skubal | | Margot |
| 6/3/2021 | | | BEA | 3 | BOM | 1 | Paddack | Urias,J | Jansen,K | McCutchen |
| 6/4/2021 | | | SEA | 3 | GOT | 9 | Lester | Fleming | | Edman |
| 6/4/2021 | | | PAN | 3 | CYC | 5 | Norris | Matz | Pressly | Gurriel,Y |
| 6/4/2021 | | | SMC | 6 | BEA | 5 | Greene | Lakins | Melancon | Plawecki |
| 6/4/2021 | | | ATK | 1 | PLU | 8 | Gonsolin | Tomlin | | Myers |
| 6/4/2021 | | | PUR | 2 | BOM | 5 | Houser | Eshelman | Colome | Dickerson,A |
| 6/4/2021 | | | NUT | 3 | NHH | 4 | Kolarek | Neris | Quantrill | Stassi |
| 6/5/2021 | | 11 | SEA | 6 | GOT | 7 | Green | Hill,R | | Caratini |
| 6/5/2021 | | | PAN | 3 | CYC | 5 | Heaney | Civale | Pressly | Albies |
| 6/5/2021 | | | SMC | 3 | BEA | 11 | Bundy | Berrios | | Cano |
| 6/5/2021 | | 10 | ATK | 5 | PLU | 6 | Scott | Martin,C | | Soler |
| 6/5/2021 | | | PUR | 4 | BOM | 1 | Hudson,Dak | deGrom | Young,Al | Gurriel,L |
| 6/5/2021 | | | NUT | 3 | NHH | 6 | Brault | Bauer | Quantrill | Wendle |
| 6/6/2021 | | | SEA | 4 | GOT | 5 | Rodriguez,Joe | Bard,D | | Nola,Au |
| 6/6/2021 | | | PAN | 4 | CYC | 3 | Duffy | Wilson,J | Hudson,Dan | Chirinos,R |
| 6/6/2021 | | | SMC | 9 | BEA | 8 | Ramirez,No | Rosenthal | Melancon | Biggio |
| 6/6/2021 | | | ATK | 2 | PLU | 3 | Davies | Yarbrough | Garcia,B | Odor |
| 6/6/2021 | | | PUR | 1 | BOM | 2 | Hendricks | Staumont | Colome | Brantley |
| 6/6/2021 | | | NUT | 3 | NHH | 5 | Barria | Senzatela | Quantrill | Urshela |
| 6/7/2021 | | | ATK | 7 | GOT | 10 | Familia | Karinchak | Barlow | Grisham |
| 6/7/2021 | | | BEA | 4 | CYC | 2 | Mize | Means | Jansen,K | Judge |
| 6/7/2021 | | | SMC | 2 | PUR | 5 | Canning | Walker,T | Jeffress | Belt |
| 6/7/2021 | | | PAN | 5 | BOM | 6 | Hader | Cordero,J | Colome | Castro,J |
| 6/7/2021 | | 10 | NUT | 5 | PLU | 7 | Garcia,B | Crichton | | Myers |
| 6/7/2021 | | | SEA | 5 | NHH | 7 | Quantrill | Baragar | | Hays |
| 6/8/2021 | | | ATK | 3 | GOT | 1 | Karinchak | Familia | Martin,C | McCann |
| 6/8/2021 | | | BEA | 3 | CYC | 6 | Garrett,B | Paddack | | Bemboom |
| 6/8/2021 | | | SMC | 4 | PUR | 1 | Luzardo | Webb,L | Ramirez,No | Biggio |
| 6/8/2021 | | | PAN | 2 | BOM | 0 | Musgrove | Urias,J | Hudson,Dan | Harrison,J |
| 6/8/2021 | | | NUT | 7 | PLU | 0 | Fedde | Maeda | | Calhoun,K |
| 6/8/2021 | | | SEA | 10 | NHH | 5 | Hill,T | Allen,L | | Jansen,D |
| 6/9/2021 | | | ATK | 8 | GOT | 7 | Graterol | Kuhl | Martin,C | Markakis |
| 6/9/2021 | | | BEA | 5 | CYC | 14 | Alexander,T | Sanchez,An | | Rosario,E |
| 6/9/2021 | | | SMC | 10 | PUR | 4 | Anderson,I | Eshelman | | Biggio |
| 6/9/2021 | | | PAN | 2 | BOM | 4 | Houser | Lopez,J | Colome | Schoop |
| 6/9/2021 | | | NUT | 4 | PLU | 2 | Fairbanks | Garcia,Ja | Dayton | Bohm |
| 6/9/2021 | | 12 | SEA | 3 | NHH | 2 | Baragar | Allen,L | Morton | Encarnacion |
| 6/11/2021 | | | GOT | 2 | NUT | 5 | Bauer | Gray,S | Fairbanks | Carlson |
| 6/11/2021 | | | CYC | 5 | PUR | 6 | Jeffress | Hunter | | Belt |
| 6/11/2021 | | | SMC | 3 | PAN | 1 | Berrios | Matz | Melancon | Abreu,J |
| 6/11/2021 | | | PLU | 5 | SEA | 7 | Bard,D | Peralta,W | Plutko | Hosmer |
| 6/11/2021 | | | NHH | 6 | ATK | 7 | Williams,D | Smeltzer | Martin,C | Pham |
| 6/11/2021 | | | BOM | 2 | BEA | 3 | Lakins | Castillo,D | | Trout |
| 6/12/2021 | | | GOT | 3 | NUT | 2 | Kershaw | Senzatela | Green | Nola,Au |
| 6/12/2021 | | | CYC | 6 | PUR | 9 | Finnegan | Strahm | Jeffress | Dozier,H |
| 6/12/2021 | | | SMC | 9 | PAN | 3 | Gonzales | Civale | | Anderson,Bri |
| 6/12/2021 | | 15 | PLU | 8 | SEA | 6 | Rogers,Ty | Baragar | | Moncada |
| 6/12/2021 | | | NHH | 3 | ATK | 1 | Barria | Yarbrough | Quantrill | Conforto |
| 6/12/2021 | | | BOM | 7 | BEA | 6 | Hill,C | Jansen,K | Colome | Schoop |
| 6/13/2021 | | | GOT | 3 | NUT | 2 | Alzolay | Javier | Green | Smith,Do |
| 6/13/2021 | | | CYC | 4 | PUR | 5 | Young,Al | Beeks | | Renfroe |
| 6/13/2021 | | | SMC | 6 | PAN | 1 | Walker,T | Duffy | Ramirez,No | Smith,P |
| 6/13/2021 | | | PLU | 10 | SEA | 5 | Rogers,Ty | Stammen | | Soler |
| 6/13/2021 | | | NHH | 2 | ATK | 0 | Minor | Montgomery,J | Quantrill | |
| 6/13/2021 | | | BOM | 5 | BEA | 6 | Mize | Wheeler | King,M | Trout |
| 6/14/2021 | | | GOT | 4 | NUT | 7 | Fedde | Tanaka | Dayton | Sano |
| 6/14/2021 | | | CYC | 8 | PUR | 3 | Garrett,B | Webb,L | | Ahmed |
| 6/14/2021 | | | SMC | 4 | PAN | 5 | Dunn | Luzardo | Hudson,Dan | |
| 6/14/2021 | | | PLU | 7 | SEA | 6 | McKenzie | Bard,D | Garcia,Ja | Odor |
| 6/14/2021 | | | NHH | 4 | ATK | 8 | Lorenzen | Gray,J | Martin,C | Solak |
| 6/14/2021 | | 10 | BOM | 12 | BEA | 13 | King,M | Colome | | Molina |
| 6/15/2021 | | | JER | 5 | CYC | 1 | Junis | Norris | Iglesias,R | Semien |
| 6/15/2021 | | | LAH | 1 | ATK | 2 | Tomlin | Garcia,D | Webb,J | McCann |
| 6/15/2021 | | | HOU | 6 | BEA | 1 | Gausman | Sanchez,An | Armstrong | Madrigal |
| 6/15/2021 | | | SCA | 6 | PAN | 3 | Wright | Musgrove | Montero | Shaw,T |
| 6/15/2021 | | | CCC | 5 | BOM | 1 | Nola,Aa | Houser | Miller,A | Kemp,M |
| 6/15/2021 | | | ISO | 7 | SMC | 0 | Cobb | Anderson,I | | Freeman,F |
| 6/15/2021 | | | LTR | 5 | NUT | 3 | Fiers | Perez,Ma | Garcia,Y | |
| 6/15/2021 | | | PHS | 9 | PUR | 2 | Cueto | Eshelman | Winkler | Miller,B |
| 6/15/2021 | | | WHC | 4 | SEA | 9 | Kintzler | Sims | | Hosmer |
| 6/15/2021 | | | LVB | 6 | GOT | 7 | Baez,P | Stripling | Barlow | Pinder |
| 6/15/2021 | | | JOT | 3 | PLU | 4 | Zuber | Holland,D | | Marte,K |
| 6/15/2021 | | | COL | 5 | NHH | 7 | Allen,L | Chatwood | | Conforto |
| 6/16/2021 | | | JER | 4 | CYC | 2 | Singer | Heaney | Iglesias,R | Semien |
| 6/16/2021 | | 15 | LAH | 9 | ATK | 5 | Valdez,C | Lorenzen | | Swanson,D |
| 6/16/2021 | | | HOU | 2 | BEA | 5 | Bundy | Marshall | Jansen,K | Judge |
| 6/16/2021 | | | SCA | 2 | PAN | 0 | Cole,G | Lopez,J | Montero | Shaw,T |
| 6/16/2021 | | | CCC | 2 | BOM | 4 | deGrom | Ryu | | Story |
| 6/16/2021 | | | ISO | 1 | SMC | 4 | Berrios | Darvish | Melancon | Riley |
| 6/16/2021 | | | LTR | 5 | NUT | 3 | Dobnak | Fairbanks | Webb,T | |
| 6/16/2021 | | | PHS | 8 | PUR | 5 | Merryweather | Staumont | | Devers |
| 6/16/2021 | | | WHC | 5 | SEA | 6 | Hill,T | Hatch | | Arcia |
| 6/16/2021 | | | LVB | 0 | GOT | 1 | Gray,S | Castellani | | |
| 6/16/2021 | | | JOT | 2 | PLU | 1 | Bieber | Sanchez,S | Castro,M | Stanton |
| 6/16/2021 | | | COL | 3 | NHH | 2 | Greinke | Brault | Gant | Adames |
| 6/17/2021 | | | JER | 3 | CYC | 9 | Means | Valdez,F | | Cabrera,M |
| 6/17/2021 | | | LAH | 5 | ATK | 3 | Woodruff | Yarbrough | Valdez,C | |
| 6/17/2021 | | | HOU | 13 | BEA | 8 | Foster | Jansen,K | | Reyes,F |
| 6/17/2021 | | | SCA | 11 | PAN | 0 | Turnbull | Matz | | Shaw,T |
| 6/17/2021 | | | CCC | 4 | BOM | 6 | Hendricks | Corbin | Colome | Dickerson,A |
| 6/17/2021 | | | ISO | 3 | SMC | 2 | Shreve | Melancon | Antone | Hilliard |
| 6/17/2021 | | | LTR | 13 | NUT | 7 | Wisler | Neris | | Olson |
| 6/17/2021 | | | PHS | 13 | PUR | 2 | Arrieta | Freeland | | Solano |
| 6/17/2021 | | | WHC | 9 | SEA | 1 | Sheffield | Snell | Hatch | Pillar |
| 6/17/2021 | | | LVB | 4 | GOT | 16 | Kershaw | Anderson,Ty | Smith,C | Grisham |
| 6/17/2021 | | | JOT | 9 | PLU | 6 | Reyes,A | Garcia,Ja | Morejon | Cronenworth |
| 6/17/2021 | | | COL | 3 | NHH | 4 | Quantrill | Lindblom | | Guzman,R |
| 6/18/2021 | | | CYC | 6 | JER | 12 | Rasmussen | Gonzalez,G | | Semien |
| 6/18/2021 | | | ATK | 4 | LAH | 8 | Keuchel | Montgomery,J | | Voit |
| 6/18/2021 | | | BEA | 5 | HOU | 6 | Smyly | Velasquez | Hahn | Walker,C |
| 6/18/2021 | | | PAN | 4 | SCA | 2 | Heuer | Montero | | Bart |
| 6/18/2021 | | 12 | BOM | 5 | CCC | 4 | Tate | Cisnero | | Brosseau |
| 6/18/2021 | | | SMC | 1 | ISO | 4 | DeSclafani | Walker,T | Antone | Freeman,F |
| 6/18/2021 | | 10 | NUT | 7 | LTR | 6 | Dayton | Yates | Marquez,B | Gallo |
| 6/18/2021 | | | PUR | 6 | PHS | 2 | Canning | Brubaker | Young,Al | Davis,JD |
| 6/18/2021 | | | SEA | 4 | WHC | 3 | Mahle | Voth | Bard,D | Encarnacion |
| 6/18/2021 | | 10 | GOT | 4 | LVB | 3 | Green | Garcia,LH | Barlow | Engel |
| 6/18/2021 | | | PLU | 3 | JOT | 11 | Bumgarner | Gibson | | Bell |
| 6/18/2021 | | | NHH | 5 | COL | 4 | Smeltzer | Pagan | Quantrill | Hays |
| 6/19/2021 | | | CYC | 9 | JER | 6 | Almonte,Y | Montas | | Bemboom |
| 6/19/2021 | | | ATK | 3 | LAH | 4 | Castillo,L | Treinen | Paredes,E | Taylor,C |
| 6/19/2021 | | | BEA | 3 | HOU | 9 | Gallen | Paddack | | Seager,K |
| 6/19/2021 | | | PAN | 5 | SCA | 11 | Bubic | Duffy | | Santana,C |
| 6/19/2021 | | | BOM | 10 | CCC | 4 | Urias,J | Lynn | | Goldschmidt |
| 6/19/2021 | | | SMC | 12 | ISO | 7 | Lugo,S | Wainwright | | Abreu,J |
| 6/19/2021 | | | NUT | 8 | LTR | 3 | Fedde | Peterson,D | | Romine,Au |
| 6/19/2021 | | | PUR | 7 | PHS | 4 | Scrubb | Giolito | Jeffress | Crawford,B |
| 6/19/2021 | | 15 | SEA | 4 | WHC | 5 | Suero | Hill,R | | Espinal |
| 6/19/2021 | | | GOT | 6 | LVB | 7 | Stephenson,R | Baez,P | | Huff |
| 6/19/2021 | | 13 | PLU | 0 | JOT | 1 | Morejon | Scott | | Stanton |
| 6/19/2021 | | | NHH | 0 | COL | 8 | Gant | Gray,J | | Akiyama |
| 6/20/2021 | | | CYC | 8 | JER | 10 | Maton | Strahm | Iglesias,R | Verdugo |
| 6/20/2021 | | | ATK | 2 | LAH | 9 | Garcia,D | Tomlin | | Ramirez,J |
| 6/20/2021 | | | BEA | 2 | HOU | 16 | Gausman | Sanchez,An | Smith,R | Tucker,K |
| 6/20/2021 | | | PAN | 0 | SCA | 6 | Wright | Dunn | | Yelich |
| 6/20/2021 | | | BOM | 1 | CCC | 3 | Diaz,Ed | Castillo,D | | Stewart,DJ |
| 6/20/2021 | | | SMC | 17 | ISO | 10 | Anderson,I | Cobb | | Grossman |
| 6/20/2021 | | | NUT | 0 | LTR | 2 | Lopez,P | Perez,Ma | Webb,T | Rojas,M |
| 6/20/2021 | | 12 | PUR | 3 | PHS | 2 | Jeffress | Kinley | Valdez,P | La Stella |
| 6/20/2021 | | | SEA | 2 | WHC | 3 | Plesac | Fleming | Holland,G | Espinal |
| 6/20/2021 | | | GOT | 8 | LVB | 3 | Lester | Akin | | Edman |
| 6/20/2021 | | | PLU | 0 | JOT | 1 | Alcantara,Sa | Glasnow | Reyes,A | Ramos,W |
| 6/20/2021 | | | NHH | 12 | COL | 3 | Ynoa | Newsome | | Guzman,R |
| 6/21/2021 | | | SEA | 8 | GOT | 4 | Bassitt | Gray,S | Plutko | Braun |
| 6/21/2021 | | | PAN | 3 | CYC | 4 | Heaney | Musgrove | Almonte,Y | Rosario,E |
| 6/21/2021 | | | SMC | 7 | BEA | 5 | Berrios | Lakins | Melancon | Grossman |
| 6/21/2021 | | | ATK | 4 | PLU | 2 | Treinen | Bass | Martin,C | Yastrzemski |
| 6/21/2021 | | | PUR | 2 | BOM | 7 | deGrom | Hudson,Dak | | LeMahieu |
| 6/21/2021 | | | NUT | 11 | NHH | 7 | Bauer | Smeltzer | | Calhoun,K |
| 6/22/2021 | | | SEA | 3 | GOT | 2 | Plutko | Kershaw | | Upton |
| 6/22/2021 | | | PAN | 3 | CYC | 7 | Means | Lopez,J | | Ahmed |
| 6/22/2021 | | | SMC | 6 | BEA | 4 | Gonzales | Porcello | Melancon | Hampson |
| 6/22/2021 | | | ATK | 6 | PLU | 4 | Karinchak | Sanchez,S | Martin,C | Franco |
| 6/22/2021 | | | PUR | 2 | BOM | 3 | Colome | Young,Al | | Story |
| 6/22/2021 | | | NUT | 1 | NHH | 2 | Quantrill | Dayton | | Stassi |
| 6/23/2021 | | | SEA | 5 | GOT | 3 | Hill,T | Rodriguez,Joe | Kintzler | Alberto |
| 6/23/2021 | | | PAN | 6 | CYC | 8 | Gonzalez,G | Matz | Strahm | Gurriel,Y |
| 6/23/2021 | | | SMC | 3 | BEA | 4 | Mize | Walker,T | Jansen,K | Wong |
| 6/23/2021 | | | ATK | 3 | PLU | 4 | Gonsolin | Montgomery,J | Rogers,Ty | Moncada |
| 6/23/2021 | | | PUR | 3 | BOM | 11 | Wheeler | Canning | | LeMahieu |
| 6/23/2021 | | | NUT | 10 | NHH | 6 | Clarke | Quantrill | | Fletcher,D |
| 6/25/2021 | | 10 | GOT | 5 | SEA | 6 | Kintzler | Green | | Goodwin |
| 6/25/2021 | | | CYC | 2 | PAN | 7 | Civale | Garrett,B | Watson | Kiner-Falefa |
| 6/25/2021 | | | BEA | 2 | SMC | 6 | Luzardo | Paddack | | d'Arnaud |
| 6/25/2021 | | | PLU | 2 | ATK | 6 | Lorenzen | Gibson | | Yastrzemski |
| 6/25/2021 | | | BOM | 7 | PUR | 3 | Urias,J | Webb,L | | LeMahieu |
| 6/25/2021 | | | NHH | 4 | NUT | 12 | Crichton | Farmer,B | Neris | Carlson |
| 6/26/2021 | | | GOT | 3 | SEA | 4 | Bard,D | Garrett,A | Kintzler | Arcia |
| 6/26/2021 | | | CYC | 2 | PAN | 5 | Duffy | Heaney | Hudson,Dan | Kiner-Falefa |
| 6/26/2021 | | | BEA | 5 | SMC | 8 | Anderson,I | Sanchez,An | Melancon | Hampson |
| 6/26/2021 | | 10 | PLU | 1 | ATK | 2 | Martin,C | Rogers,Ty | | Franco |
| 6/26/2021 | | | BOM | 9 | PUR | 6 | Hill,C | Eshelman | Wendelken | Story |
| 6/26/2021 | | | NHH | 3 | NUT | 9 | Perez,Ma | Ynoa | | |
| 6/27/2021 | | | GOT | 4 | SEA | 7 | Bassitt | Gray,S | | Lowe,B |
| 6/27/2021 | | | CYC | 8 | PAN | 4 | Alexander,T | Trivino | | Bemboom |
| 6/27/2021 | | | BEA | 6 | SMC | 5 | Bundy | Berrios | Jansen,K | Harper,B |
| 6/27/2021 | | | PLU | 5 | ATK | 6 | Karinchak | Garcia,B | | Valaika |
| 6/27/2021 | | | BOM | 4 | PUR | 1 | Castillo,D | Jeffress | Colome | Dickerson,A |
| 6/27/2021 | | | NHH | 2 | NUT | 1 | Farmer,B | Dayton | Quantrill | Conforto |
| 6/28/2021 | | 10 | GOT | 3 | ATK | 4 | McGee | Rodriguez,Joe | | Yastrzemski |
| 6/28/2021 | | | CYC | 9 | BEA | 6 | Gonzalez,G | Porcello | Strahm | Gurriel,Y |
| 6/28/2021 | | | PUR | 3 | SMC | 6 | Gonzales | Freeland | | Plawecki |
| 6/28/2021 | | | BOM | 5 | PAN | 3 | Hendricks | Musgrove | Wendelken | Winker |
| 6/28/2021 | | | PLU | 1 | NUT | 7 | Senzatela | Maeda | | Gimenez |
| 6/28/2021 | | 13 | NHH | 5 | SEA | 6 | Hill,R | Smeltzer | | Upton |
| 6/29/2021 | | | GOT | 3 | ATK | 4 | Montgomery,J | Alzolay | Graterol | Franco |
| 6/29/2021 | | | CYC | 11 | BEA | 8 | Wilson,J | Mize | | Rosario,E |
| 6/29/2021 | | | PUR | 6 | SMC | 8 | Lugo,S | Young,Al | Melancon | Anderson,Bri |
| 6/29/2021 | | | BOM | 13 | PAN | 0 | Wheeler | Lopez,J | | LeMahieu |
| 6/29/2021 | | | PLU | 5 | NUT | 6 | Crichton | Sanchez,S | Dayton | Carlson |
| 6/29/2021 | | | NHH | 2 | SEA | 5 | Plutko | Minor | Hill,T | Hosmer |
| 6/30/2021 | | 12 | GOT | 7 | ATK | 6 | Green | Williams,D | | |
| 6/30/2021 | | | CYC | 5 | BEA | 9 | Pomeranz | Garrett,B | | Tejeda |
| 6/30/2021 | | | PUR | 12 | SMC | 2 | Webb,L | Luzardo | Young,Al | Dozier,H |
| 6/30/2021 | | | BOM | 5 | PAN | 2 | Urias,J | Matz | Colome | Stallings |
| 6/30/2021 | | | PLU | 1 | NUT | 3 | Fedde | Gonsolin | Clarke | Sano |
| 6/30/2021 | | | NHH | 7 | SEA | 5 | Gray,J | Carrasco | Tepera | Lewis |
| 7/1/2021 | | | BOM | 3 | GOT | 5 | Smith,WM | Houser | Green | Nola,Au |
| 7/1/2021 | | | CYC | 3 | SEA | 0 | Heaney | Fleming | Alexander,T | Ahmed |
| 7/1/2021 | | | SMC | 6 | NUT | 5 | Matzek | Fairbanks | Melancon | Plawecki |
| 7/1/2021 | | | PLU | 7 | PAN | 5 | Gibson | Civale | Garcia,B | Soler |
| 7/1/2021 | | | BEA | 15 | ATK | 2 | Sanchez,An | Tomlin | | Tejeda |
| 7/1/2021 | | | NHH | 12 | PUR | 13 | Ray | Smeltzer | | Severino |
| 7/2/2021 | | | BOM | 8 | GOT | 2 | deGrom | Gray,S | | Dickerson,A |
| 7/2/2021 | | | CYC | 5 | SEA | 4 | Means | Plutko | Pressly | Gurriel,Y |
| 7/2/2021 | | | SMC | 0 | NUT | 9 | Bauer | Berrios | Marquez,B | Romine,Au |
| 7/2/2021 | | | PLU | 6 | PAN | 1 | Davies | Duffy | | Adell |
| 7/2/2021 | | | BEA | 3 | ATK | 5 | Karinchak | Bundy | Martin,C | Solak |
| 7/2/2021 | | 10 | NHH | 3 | PUR | 4 | Staumont | Allen,L | | Gurriel,L |
| 7/3/2021 | | | BOM | 2 | GOT | 1 | Hendricks | Kershaw | Colome | Story |
| 7/3/2021 | | | CYC | 5 | SEA | 4 | Hunter | Kintzler | Strahm | Rosario,E |
| 7/3/2021 | | | SMC | 5 | NUT | 1 | Gonzales | Senzatela | | d'Arnaud |
| 7/3/2021 | | | PLU | 0 | PAN | 7 | Dunn | Glasnow | | Robert |
| 7/3/2021 | | | BEA | 3 | ATK | 1 | Porcello | Yarbrough | Jansen,K | Judge |
| 7/3/2021 | | | NHH | 7 | PUR | 6 | Allen,L | Young,Al | Quantrill | Hays |
| 7/4/2021 | | | GOT | 4 | SMC | 2 | Garrett,A | Walker,T | Green | Gregorius |
| 7/4/2021 | | | PLU | 0 | CYC | 4 | Norris | Maeda | | Albies |
| 7/4/2021 | | | SEA | 4 | PAN | 7 | Trivino | Plutko | Hudson,Dan | Munoz |
| 7/4/2021 | | | PUR | 3 | ATK | 5 | Graterol | Young,Al | Martin,C | Gonzalez,M |
| 7/4/2021 | | | NHH | 2 | BOM | 3 | Wheeler | Minor | Hader | Davis,K |
| 7/4/2021 | | | BEA | 3 | NUT | 10 | Javier | Mize | | Calhoun,K |
| 7/5/2021 | | | GOT | 4 | SMC | 13 | Luzardo | Tanaka | | Hampson |
| 7/5/2021 | | | PLU | 3 | CYC | 4 | Almonte,Y | Garcia,B | | Cabrera,M |
| 7/5/2021 | | | SEA | 0 | PAN | 3 | Lopez,J | Carrasco | Hudson,Dan | Kiner-Falefa |
| 7/5/2021 | | | PUR | 10 | ATK | 7 | Young,Al | Williams,D | Brasier | Crawford,B |
| 7/5/2021 | | | NHH | 5 | BOM | 20 | Urias,J | Farmer,B | | Dickerson,A |
| 7/5/2021 | | | BEA | 4 | NUT | 2 | Lakins | Dayton | Jansen,K | Flores,W |
| 7/6/2021 | | | GOT | 3 | SMC | 6 | Anderson,I | Lester | | Riley |
| 7/6/2021 | | | PLU | 1 | CYC | 4 | Heaney | Gonsolin | Pressly | Bradley,J |
| 7/6/2021 | | | SEA | 14 | PAN | 5 | Fleming | Matz | | Alberto |
| 7/6/2021 | | | PUR | 3 | ATK | 9 | Tomlin | Eshelman | | Franco |
| 7/6/2021 | | | NHH | 9 | BOM | 12 | Castillo,D | Quantrill | Colome | LeMahieu |
| 7/6/2021 | | 10 | BEA | 14 | NUT | 13 | Pomeranz | Dayton | Jansen,K | |
| 7/7/2021 | | | BEA | 7 | GOT | 2 | Bundy | Gray,S | | Cano |
| 7/7/2021 | | | NHH | 7 | CYC | 15 | Means | Brault | | Gurriel,Y |
| 7/7/2021 | | | PLU | 5 | SMC | 1 | Gibson | Berrios | Bass | Myers |
| 7/7/2021 | | | NUT | 4 | PAN | 3 | Bauer | Civale | Neris | Aquino |
| 7/7/2021 | | | PUR | 8 | SEA | 4 | Finnegan | Bard,D | | Crawford,B |
| 7/7/2021 | | | BOM | 1 | ATK | 2 | Treinen | Tate | Martin,C | Valaika |
| 7/8/2021 | | 12 | BEA | 7 | GOT | 6 | Jansen,K | Garrett,A | | Harper,B |
| 7/8/2021 | | | NHH | 4 | CYC | 7 | Gonzalez,G | Barria | Pressly | Ahmed |
| 7/8/2021 | | | PLU | 5 | SMC | 6 | Melancon | Rogers,Ty | | Anderson,Bri |
| 7/8/2021 | | 11 | NUT | 0 | PAN | 1 | Trivino | Clarke | | Moreland |
| 7/8/2021 | | | PUR | 6 | SEA | 7 | Bard,D | Staumont | | Perez,Mi |
| 7/8/2021 | | | BOM | 3 | ATK | 2 | Hendricks | McGee | Colome | Schoop |
| 7/9/2021 | | | BEA | 3 | GOT | 8 | Alzolay | Mize | | Edman |
| 7/9/2021 | | | NHH | 4 | CYC | 6 | Beeks | Minor | Pressly | Casali |
| 7/9/2021 | | | PLU | 0 | SMC | 7 | Walker,T | Glasnow | | Abreu,J |
| 7/9/2021 | | 11 | NUT | 4 | PAN | 5 | Watson | Clarke | | Harrison,J |
| 7/9/2021 | | | PUR | 5 | SEA | 12 | Mahle | Canning | | Ruiz,R |
| 7/9/2021 | | | BOM | 9 | ATK | 2 | Wheeler | Montgomery,J | | |
| 7/14/2021 | | | NUT | 2 | GOT | 1 | Neris | Green | Dayton | Aquino |
| 7/14/2021 | | | PUR | 14 | CYC | 5 | Webb,L | Heaney | | Grichuk |
| 7/14/2021 | | | PAN | 5 | SMC | 3 | Musgrove | Luzardo | Hudson,Dan | Harrison,J |
| 7/14/2021 | | | SEA | 5 | PLU | 3 | Carrasco | Maeda | Bard,D | Goodwin |
| 7/14/2021 | | | ATK | 6 | NHH | 4 | Skubal | Gray,J | Martin,C | Yastrzemski |
| 7/14/2021 | | | BEA | 1 | BOM | 4 | Hader | Rosenthal | Colome | Dickerson,A |
| 7/15/2021 | | | NUT | 8 | GOT | 2 | Perez,Ma | Lester | | Longoria |
| 7/15/2021 | | | PUR | 6 | CYC | 13 | Means | Eshelman | | Rosario,E |
| 7/15/2021 | | | PAN | 1 | SMC | 3 | Anderson,I | Lopez,J | Melancon | Biggio |
| 7/15/2021 | | 12 | SEA | 7 | PLU | 5 | Plutko | Peralta,W | | Ruiz,R |
| 7/15/2021 | | 10 | ATK | 12 | NHH | 7 | Williams,D | Quantrill | | McCann |
| 7/15/2021 | | | BEA | 4 | BOM | 5 | Colome | Jansen,K | | Castro,J |
| 7/16/2021 | | | NUT | 4 | GOT | 0 | Bauer | Gray,S | | Gimenez |
| 7/16/2021 | | | PUR | 13 | CYC | 7 | Jeffress | Garrett,B | | Grichuk |
| 7/16/2021 | | | PAN | 5 | SMC | 4 | Turley | Berrios | Hudson,Dan | Bart |
| 7/16/2021 | | | SEA | 1 | PLU | 3 | Gonsolin | Bassitt | Garcia,B | Myers |
| 7/16/2021 | | | ATK | 2 | NHH | 3 | Brault | Fried | Quantrill | Stassi |
| 7/16/2021 | | | BEA | 2 | BOM | 3 | deGrom | Bundy | Tate | Schoop |
| 7/17/2021 | | | NUT | 2 | GOT | 8 | Kershaw | Senzatela | Hernandez,J | Pinder |
| 7/17/2021 | | | PUR | 2 | CYC | 7 | Hunter | Freeland | | Cabrera,M |
| 7/17/2021 | | | PAN | 4 | SMC | 5 | Ramirez,No | Watson | Melancon | Grossman |
| 7/17/2021 | | | SEA | 1 | PLU | 5 | Gibson | Snell | | Myers |
| 7/17/2021 | | | ATK | 7 | NHH | 2 | Yarbrough | Barria | | Franco |
| 7/17/2021 | | | BEA | 4 | BOM | 1 | Thompson | Hendricks | Jansen,K | Trout |
| 7/18/2021 | | 11 | GOT | 6 | BOM | 3 | Green | Castillo,D | | Pinder |
| 7/18/2021 | | | SEA | 1 | CYC | 3 | Wilson,J | Mahle | Pressly | Rosario,E |
| 7/18/2021 | | | NUT | 8 | SMC | 11 | Ramirez,No | Dayton | Melancon | Quinn |
| 7/18/2021 | | | PAN | 1 | PLU | 4 | Davies | Duffy | Scott | Odor |
| 7/18/2021 | | | ATK | 4 | BEA | 1 | Montgomery,J | Mize | Martin,C | Long |
| 7/18/2021 | | | PUR | 5 | NHH | 2 | Canning | Minor | Jeffress | Grichuk |
| 7/19/2021 | | | GOT | 5 | BOM | 6 | Romano,J | Garrett,A | Colome | Story |
| 7/19/2021 | | | SEA | 11 | CYC | 4 | Carrasco | Heaney | | Hosmer |
| 7/19/2021 | | | NUT | 5 | SMC | 3 | Fedde | Luzardo | Dayton | Bohm |
| 7/19/2021 | | | PAN | 4 | PLU | 2 | Dunn | Glasnow | Wick | Smith,M |
| 7/19/2021 | | | ATK | 9 | BEA | 8 | Skubal | Paddack | Martin,C | Franco |
| 7/19/2021 | | | PUR | 4 | NHH | 5 | Kolarek | Brasier | | Frazier,T |
| 7/20/2021 | | | GOT | 9 | BOM | 8 | Lester | Houser | Rodriguez,Joe | Nola,Au |
| 7/20/2021 | | | SEA | 10 | CYC | 8 | Fleming | Means | | Upton |
| 7/20/2021 | | | NUT | 6 | SMC | 9 | Anderson,I | Perez,Ma | | Plawecki |
| 7/20/2021 | | | PAN | 1 | PLU | 5 | Maeda | Musgrove | | Bregman |
| 7/20/2021 | | | ATK | 5 | BEA | 9 | Sanchez,An | Tomlin | | Smith,WD |
| 7/20/2021 | | | PUR | 7 | NHH | 9 | Farmer,B | Scrubb | Quantrill | Conforto |
| 7/22/2021 | | | GOT | 4 | NUT | 2 | Gray,S | Bauer | Green | Nunez,R |
| 7/22/2021 | | | CYC | 0 | PUR | 5 | Hudson,Dak | Gonzalez,G | | |
| 7/22/2021 | | | SMC | 3 | PAN | 1 | Berrios | Lopez,J | Melancon | Anderson,Bri |
| 7/22/2021 | | | PLU | 1 | SEA | 3 | Bassitt | Sanchez,S | Kintzler | Encarnacion |
| 7/22/2021 | | | NHH | 0 | ATK | 2 | Fried | Brault | Martin,C | |
| 7/22/2021 | | | BOM | 15 | BEA | 2 | deGrom | Bundy | | LeMahieu |
| 7/23/2021 | | | GOT | 4 | NUT | 0 | Kershaw | Senzatela | Green | Kepler |
| 7/23/2021 | | | CYC | 3 | PUR | 6 | Freeland | Garrett,B | Jeffress | Davis,JD |
| 7/23/2021 | | 16 | SMC | 6 | PAN | 4 | Ferguson | Wick | | Camargo |
| 7/23/2021 | | | PLU | 7 | SEA | 4 | Gonsolin | Snell | Garcia,B | DeShields |
| 7/23/2021 | | 12 | NHH | 8 | ATK | 7 | Smeltzer | Williams,D | Kolarek | Stassi |
| 7/23/2021 | | | BOM | 2 | BEA | 6 | Porcello | Hendricks | | Tejeda |
| 7/24/2021 | | | GOT | 18 | NUT | 1 | Baez,P | Javier | Kuhl | Nunez,R |
| 7/24/2021 | | | CYC | 6 | PUR | 7 | Brasier | Pressly | | Gurriel,L |
| 7/24/2021 | | | SMC | 6 | PAN | 5 | Loup | Cordero,J | | Sierra |
| 7/24/2021 | | | PLU | 2 | SEA | 3 | Mahle | Gibson | Plutko | Moore |
| 7/24/2021 | | | NHH | 3 | ATK | 6 | Montgomery,J | Minor | Martin,C | Gosselin |
| 7/24/2021 | | | BOM | 3 | BEA | 7 | Mize | Wheeler | Rosenthal | |
| 7/26/2021 | | | SMC | 10 | GOT | 16 | Familia | Luzardo | | Caratini |
| 7/26/2021 | | | CYC | 10 | PLU | 2 | Means | Davies | | Rosario,E |
| 7/26/2021 | | 10 | PAN | 11 | SEA | 12 | Hill,T | Wick | | Ruiz,R |
| 7/26/2021 | | | ATK | 5 | PUR | 1 | Skubal | Webb,L | | Gonzalez,M |
| 7/26/2021 | | | BOM | 5 | NHH | 1 | Urias,J | Gray,J | | Winker |
| 7/26/2021 | | | NUT | 2 | BEA | 3 | Jansen,K | Neris | | Smith,WD |
| 7/27/2021 | | 10 | SMC | 2 | GOT | 3 | Green | Melancon | | Gregorius |
| 7/27/2021 | | | CYC | 10 | PLU | 3 | Gonzalez,G | Glasnow | Alexander,T | Albies |
| 7/27/2021 | | | PAN | 4 | SEA | 12 | Fleming | Dunn | | Lowe,B |
| 7/27/2021 | | | ATK | 12 | PUR | 5 | Tomlin | Eshelman | | Franco |
| 7/27/2021 | | | BOM | 5 | NHH | 10 | Ynoa | Houser | | |
| 7/27/2021 | | 10 | NUT | 8 | BEA | 9 | Velasquez | Dayton | | Flores,W |
| 7/28/2021 | | | SMC | 0 | GOT | 2 | Gray,S | Berrios | Garrett,A | Nola,Au |
| 7/28/2021 | | | CYC | 4 | PLU | 5 | Garcia,B | Almonte,Y | | Varsho |
| 7/28/2021 | | | PAN | 12 | SEA | 3 | Heuer | Bassitt | | McNeil |
| 7/28/2021 | | | ATK | 7 | PUR | 1 | Williams,D | Hudson,Dak | | McCann |
| 7/28/2021 | | | BOM | 0 | NHH | 4 | Brault | deGrom | | Hays |
| 7/28/2021 | | 12 | NUT | 3 | BEA | 5 | Pomeranz | Dayton | | Judge |
| 7/29/2021 | | | GOT | 7 | BEA | 2 | Kershaw | Fry,P | | |
| 7/29/2021 | | | CYC | 1 | NHH | 3 | Allen,L | Hunter | Quantrill | Stassi |
| 7/29/2021 | | | SMC | 6 | PLU | 5 | Gonzales | Bass | Melancon | d'Arnaud |
| 7/29/2021 | | | PAN | 2 | NUT | 8 | Senzatela | Lopez,J | | |
| 7/29/2021 | | | SEA | 4 | PUR | 2 | Bard,D | Staumont | Stammen | Marmolejos |
| 7/29/2021 | | | ATK | 1 | BOM | 4 | Hendricks | Yarbrough | Colome | Goldschmidt |
| 7/30/2021 | | | GOT | 8 | BEA | 4 | Familia | Mize | | Grisham |
| 7/30/2021 | | 10 | CYC | 3 | NHH | 4 | Quantrill | Strahm | | Hays |
| 7/30/2021 | | 14 | SMC | 2 | PLU | 1 | Cishek | Scott | Ferguson | Camargo |
| 7/30/2021 | | | PAN | 5 | NUT | 4 | Cordero,J | Mazza | Hudson,Dan | Moreland |
| 7/30/2021 | | | SEA | 1 | PUR | 9 | Canning | Mahle | | Davis,JD |
| 7/30/2021 | | | ATK | 0 | BOM | 4 | Wheeler | Montgomery,J | | Brosseau |
| 7/31/2021 | | | GOT | 5 | BEA | 6 | Velasquez | Barlow | | Wong |
| 7/31/2021 | | | CYC | 6 | NHH | 7 | Farmer,B | Strahm | | Conforto |
| 7/31/2021 | | | SMC | 8 | PLU | 7 | Matzek | Rogers,Ty | | Anderson,Bri |
| 7/31/2021 | | 14 | PAN | 4 | NUT | 3 | Trivino | Clarke | Patino | Marisnick |
| 7/31/2021 | | | SEA | 6 | PUR | 1 | Carrasco | Webb,L | Kintzler | Braun |
| 7/31/2021 | | | ATK | 6 | BOM | 4 | Skubal | Urias,J | Martin,C | Pham |
| 8/1/2021 | | | GOT | 4 | SMC | 6 | Matzek | Baez,P | Loup | Riley |
| 8/1/2021 | | | PLU | 8 | CYC | 9 | Beeks | Rodon | | Cabrera,M |
| 8/1/2021 | | 10 | SEA | 7 | PAN | 6 | Plutko | Patino | | Marmolejos |
| 8/1/2021 | | | ATK | 0 | PUR | 3 | Young,Al | Tomlin | Jeffress | Gurriel,L |
| 8/1/2021 | | | NHH | 3 | BOM | 8 | Hader | Kolarek | | Brosseau |
| 8/1/2021 | | | NUT | 9 | BEA | 7 | Crichton | Rosenthal | Fairbanks | Calhoun,K |
| 8/2/2021 | | | GOT | 3 | SMC | 2 | Gray,S | Berrios | Green | Edman |
| 8/2/2021 | | | PLU | 5 | CYC | 1 | Glasnow | Garrett,B | | Odor |
| 8/2/2021 | | | SEA | 5 | PAN | 4 | Bassitt | Dunn | Plutko | Lowe,B |
| 8/2/2021 | | | ATK | 3 | PUR | 1 | Fried | Hudson,Dak | Martin,C | Franco |
| 8/2/2021 | | | NHH | 7 | BOM | 3 | Brault | deGrom | Quantrill | Hays |
| 8/2/2021 | | 11 | NUT | 3 | BEA | 2 | Dayton | Jansen,K | | Longoria |
| 8/3/2021 | | | GOT | 5 | SMC | 3 | Kershaw | Gonzales | Green | Smith,Do |
| 8/3/2021 | | 11 | PLU | 4 | CYC | 5 | Hunter | Selman | | Bradley,J |
| 8/3/2021 | | | SEA | 4 | PAN | 6 | Trivino | Kintzler | Wick | McNeil |
| 8/3/2021 | | | ATK | 10 | PUR | 1 | Yarbrough | Freeland | | McCann |
| 8/3/2021 | | 11 | NHH | 4 | BOM | 5 | Colome | Smeltzer | | Winker |
| 8/3/2021 | | | NUT | 2 | BEA | 13 | Porcello | Senzatela | | Tejeda |
| 8/4/2021 | | | GOT | 1 | BOM | 6 | Wheeler | Alzolay | | Schoop |
| 8/4/2021 | | | NHH | 3 | CYC | 11 | Norris | Minor | | Ahmed |
| 8/4/2021 | | 14 | PLU | 8 | SMC | 6 | Scott | Ramirez,No | | Soler |
| 8/4/2021 | | 10 | NUT | 6 | PAN | 7 | Hudson,Dan | Clarke | | Moreland |
| 8/4/2021 | | | SEA | 3 | PUR | 4 | Finnegan | Plutko | Jeffress | Gurriel,L |
| 8/4/2021 | | | ATK | 12 | BEA | 9 | Treinen | Fry,P | Martin,C | Valaika |
| 8/5/2021 | | 12 | GOT | 4 | BOM | 5 | Castillo,D | Barlow | | Goldschmidt |
| 8/5/2021 | | | NHH | 4 | CYC | 3 | Gray,J | Means | Quantrill | Conforto |
| 8/5/2021 | | | PLU | 13 | SMC | 2 | Gonsolin | Luzardo | | DeShields |
| 8/5/2021 | | | NUT | 5 | PAN | 1 | Fedde | Matz | | Calhoun,K |
| 8/5/2021 | | | SEA | 8 | PUR | 4 | Carrasco | Webb,L | Stammen | Braun |
| 8/5/2021 | | | ATK | 8 | BEA | 3 | Skubal | Paddack | | Valaika |
| 8/6/2021 | | | GOT | 3 | BOM | 6 | Houser | Lester | Colome | Schoop |
| 8/6/2021 | | | NHH | 8 | CYC | 2 | Ynoa | Gonzalez,G | | Conforto |
| 8/6/2021 | | | PLU | 2 | SMC | 9 | Anderson,I | Gibson | | Kendrick |
| 8/6/2021 | | | NUT | 4 | PAN | 3 | Perez,Ma | Civale | Mazza | Iglesias,J |
| 8/6/2021 | | | SEA | 5 | PUR | 3 | Fleming | Eshelman | Plutko | Lowe,B |
| 8/6/2021 | | | ATK | 9 | BEA | 7 | McGee | Sanchez,An | Martin,C | Long |
| 8/7/2021 | | | GOT | 8 | CYC | 7 | Hernandez,J | Garrett,B | Garrett,A | Arenado |
| 8/7/2021 | | | NHH | 7 | SMC | 2 | Brault | Loup | | Reyes,V |
| 8/7/2021 | | | ATK | 5 | PAN | 3 | Fried | Duffy | Graterol | Markakis |
| 8/7/2021 | | | PLU | 2 | BOM | 4 | deGrom | Davies | Romano,J | LeMahieu |
| 8/7/2021 | | | SEA | 0 | BEA | 3 | Bundy | Bassitt | Jansen,K | Harper,B |
| 8/7/2021 | | | NUT | 3 | PUR | 6 | Jeffress | Dayton | | Gurriel,L |
| 8/8/2021 | | | GOT | 2 | CYC | 3 | Heaney | Kershaw | Pressly | Gonzalez,E |
| 8/8/2021 | | | NHH | 3 | SMC | 1 | Barria | Gonzales | Quantrill | Stassi |
| 8/8/2021 | | | ATK | 7 | PAN | 2 | Yarbrough | Dunn | | Long |
| 8/8/2021 | | | PLU | 7 | BOM | 2 | Peralta,W | Hendricks | Garcia,Ja | Odor |
| 8/8/2021 | | | SEA | 3 | BEA | 5 | Porcello | Snell | Jansen,K | Tejeda |
| 8/8/2021 | | | NUT | 3 | PUR | 4 | Brasier | Senzatela | Jeffress | La Stella |
| 8/9/2021 | | | GOT | 9 | CYC | 1 | Familia | Norris | Smith,WM | Grisham |
| 8/9/2021 | | | NHH | 2 | SMC | 3 | Walker,T | Allen,L | Melancon | Riley |
| 8/9/2021 | | | ATK | 2 | PAN | 1 | Montgomery,J | Musgrove | Williams,D | Yastrzemski |
| 8/9/2021 | | | PLU | 5 | BOM | 7 | Wheeler | Maeda | | Schoop |
| 8/9/2021 | | | SEA | 10 | BEA | 4 | Mahle | Mize | | Jansen,D |
| 8/9/2021 | | | NUT | 12 | PUR | 6 | Javier | Canning | | Calhoun,K |
| 8/10/2021 | | | GOT | 1 | CYC | 6 | Means | Tanaka | Wilson,J | Bemboom |
| 8/10/2021 | | 10 | NHH | 6 | SMC | 5 | Quantrill | Melancon | | Stassi |
| 8/10/2021 | | | ATK | 6 | PAN | 4 | Skubal | Heuer | Karinchak | Solak |
| 8/10/2021 | | | PLU | 3 | BOM | 7 | Urias,J | Sanchez,S | | Story |
| 8/10/2021 | | | SEA | 9 | BEA | 1 | Carrasco | Paddack | Plutko | |
| 8/10/2021 | | | NUT | 2 | PUR | 3 | Young,Al | Neris | Brasier | Hernandez,T |
| 8/12/2021 | | | SMC | 8 | GOT | 1 | Anderson,I | Lester | Matzek | Abreu,J |
| 8/12/2021 | | | CYC | 1 | PLU | 5 | Gonsolin | Gonzalez,G | | Marte,K |
| 8/12/2021 | | 12 | PAN | 7 | SEA | 6 | Wick | Plutko | Patino | Kiner-Falefa |
| 8/12/2021 | | | PUR | 5 | ATK | 1 | Eshelman | Tomlin | | Severino |
| 8/12/2021 | | | BOM | 11 | NHH | 4 | Wendelken | Tepera | | Winker |
| 8/12/2021 | | 10 | BEA | 6 | NUT | 7 | Dayton | Lakins | | Iglesias,J |
| 8/13/2021 | | | SMC | 6 | GOT | 10 | Gray,S | Berrios | | Kepler |
| 8/13/2021 | | | CYC | 5 | PLU | 3 | Heaney | Gibson | Pressly | Castellanos,N |
| 8/13/2021 | | | PAN | 5 | SEA | 2 | Civale | Bassitt | Hudson,Dan | Moreland |
| 8/13/2021 | | | PUR | 4 | ATK | 8 | Williams,D | Young,Al | | Votto |
| 8/13/2021 | | | BOM | 6 | NHH | 7 | Farmer,B | deGrom | Quantrill | Lewis |
| 8/13/2021 | | | BEA | 8 | NUT | 3 | Bundy | Bauer | | Cano |
| 8/14/2021 | | | SMC | 0 | GOT | 2 | Garrett,A | Greene | Green | Edman |
| 8/14/2021 | | | CYC | 8 | PLU | 6 | Tropeano | Garcia,Ja | Pressly | Gonzalez,E |
| 8/14/2021 | | | PAN | 5 | SEA | 3 | Duffy | Bard,D | | Munoz |
| 8/14/2021 | | | PUR | 3 | ATK | 4 | Yarbrough | Freeland | Martin,C | Gosselin |
| 8/14/2021 | | | BOM | 6 | NHH | 7 | Smeltzer | Colome | | Urshela |
| 8/14/2021 | | | BEA | 11 | NUT | 12 | Fairbanks | Lakins | Dayton | Iglesias,J |
| 8/15/2021 | | | BOM | 0 | GOT | 5 | Alzolay | Wheeler | | Edman |
| 8/15/2021 | | 10 | CYC | 7 | NHH | 8 | Quantrill | Wilson,J | | Stassi |
| 8/15/2021 | | | SMC | 7 | PLU | 15 | Zuber | Lugo,S | | Varsho |
| 8/15/2021 | | | PAN | 2 | NUT | 3 | Javier | Dunn | Dayton | Carlson |
| 8/15/2021 | | | PUR | 8 | SEA | 16 | Plutko | Staumont | | Braun |
| 8/15/2021 | | | BEA | 7 | ATK | 0 | Mize | Montgomery,J | | Flores,W |
| 8/16/2021 | | | BOM | 11 | GOT | 2 | Urias,J | Tanaka | | Winker |
| 8/16/2021 | | | CYC | 2 | NHH | 7 | Gray,J | Norris | | Bote |
| 8/16/2021 | | | SMC | 1 | PLU | 8 | Maeda | Luzardo | | Adell |
| 8/16/2021 | | | PAN | 3 | NUT | 2 | Musgrove | Fedde | Watson | McNeil |
| 8/16/2021 | | | PUR | 2 | SEA | 6 | Carrasco | Webb,L | | Hosmer |
| 8/16/2021 | | | BEA | 7 | ATK | 5 | Paddack | Williams,D | Jansen,K | Harper,B |
| 8/17/2021 | | | BOM | 5 | GOT | 2 | Houser | Lester | Hader | LeMahieu |
| 8/17/2021 | | | CYC | 9 | NHH | 2 | Gonzalez,G | Ynoa | Beeks | Bradley,J |
| 8/17/2021 | | | SMC | 4 | PLU | 1 | Greene | Garcia,B | Melancon | Biggio |
| 8/17/2021 | | | PAN | 2 | NUT | 5 | Perez,Ma | Lopez,J | Dayton | Gimenez |
| 8/17/2021 | | | PUR | 3 | SEA | 0 | Eshelman | Fleming | Jeffress | Garver |
| 8/17/2021 | | | BEA | 9 | ATK | 6 | Sanchez,An | McGee | | Wong |
| 8/19/2021 | | 11 | JER | 7 | PUR | 4 | Gonzalez,V | Jeffress | Iglesias,R | Acuna |
| 8/19/2021 | | 12 | LAH | 8 | SMC | 9 | Ramirez,No | Thielbar | | Abreu,J |
| 8/19/2021 | | | HOU | 8 | PLU | 3 | Buehler | Gonsolin | | Springer |
| 8/19/2021 | | | SCA | 2 | NHH | 9 | Brault | Wacha | | Guzman,R |
| 8/19/2021 | | | CCC | 1 | BEA | 4 | Thompson | Corbin | Fry,P | Cano |
| 8/19/2021 | | | ISO | 8 | PAN | 4 | Darvish | Matz | | Contreras,WE |
| 8/19/2021 | | | LTR | 9 | CYC | 2 | Dobnak | Heaney | | Rojas,M |
| 8/19/2021 | | | PHS | 0 | GOT | 8 | Gray,S | Cahill | | Grisham |
| 8/19/2021 | | | WHC | 3 | BOM | 5 | deGrom | Keller,B | Colome | LeMahieu |
| 8/19/2021 | | | JOT | 4 | SEA | 0 | Bieber | Bassitt | | Peralta,D |
| 8/19/2021 | | | COL | 2 | ATK | 7 | Fried | Greinke | Karinchak | Valaika |
| 8/19/2021 | | | LVB | 7 | NUT | 15 | Crichton | Stripling | | Fletcher,D |
| 8/20/2021 | | | JER | 6 | PUR | 4 | Valdez,F | Freeland | Iglesias,R | Semien |
| 8/20/2021 | | 12 | LAH | 8 | SMC | 3 | Perez,O | Loup | | Voit |
| 8/20/2021 | | | HOU | 3 | PLU | 4 | Garcia,B | Smyly | | Marte,K |
| 8/20/2021 | | | SCA | 3 | NHH | 5 | Allen,L | Turnbull | Quantrill | Kipnis |
| 8/20/2021 | | | CCC | 5 | BEA | 8 | Porcello | Marquez,G | Jansen,K | Harper,B |
| 8/20/2021 | | | ISO | 5 | PAN | 3 | Kim | Civale | Antone | Seager,C |
| 8/20/2021 | | | LTR | 12 | CYC | 7 | Zimmer,K | Wilson,J | | Soto,J |
| 8/20/2021 | | | PHS | 4 | GOT | 2 | Shoemaker | Kershaw | Anderson,N | Profar |
| 8/20/2021 | | | WHC | 4 | BOM | 9 | Hendricks | Plesac | Castillo,D | Brantley |
| 8/20/2021 | | | JOT | 9 | SEA | 3 | McCullers | Snell | | Peralta,D |
| 8/20/2021 | | | COL | 1 | ATK | 4 | Yarbrough | Scherzer | Martin,C | Franco |
| 8/20/2021 | | | LVB | 4 | NUT | 14 | Senzatela | Anderson,Ty | | Longoria |
| 8/21/2021 | | | JER | 1 | PUR | 2 | Canning | Roark | Young,Al | Gurriel,L |
| 8/21/2021 | | | LAH | 8 | SMC | 0 | Keuchel | Walker,T | | Meadows |
| 8/21/2021 | | | HOU | 7 | PLU | 1 | Lamet | Davies | | Kelly,C |
| 8/21/2021 | | | SCA | 11 | NHH | 2 | Boyd | Minor | | Pollock |
| 8/21/2021 | | | CCC | 8 | BEA | 4 | Lynn | Mize | | Rizzo |
| 8/21/2021 | | | ISO | 2 | PAN | 1 | Clevinger | Duffy | Antone | Slater |
| 8/21/2021 | | | LTR | 10 | CYC | 3 | Peterson,D | Garrett,B | | Tellez |
| 8/21/2021 | | | PHS | 0 | GOT | 3 | Familia | Brubaker | Green | Kepler |
| 8/21/2021 | | | WHC | 3 | BOM | 7 | Wheeler | Sheffield | | Brosseau |
| 8/21/2021 | | | JOT | 9 | SEA | 3 | Bumgarner | Mahle | Alcala | Anderson,Ti |
| 8/21/2021 | | | COL | 3 | ATK | 5 | Treinen | Kay | Williams,D | Yastrzemski |
| 8/21/2021 | | | LVB | 2 | NUT | 12 | Javier | Akin | | Iglesias,J |
| 8/22/2021 | | | PUR | 4 | JER | 3 | Staumont | Montas | Jeffress | Crawford,B |
| 8/22/2021 | | | SMC | 0 | LAH | 4 | Woodruff | Luzardo | | Merrifield |
| 8/22/2021 | | | PLU | 1 | HOU | 2 | Gallen | Glasnow | Hahn | Reyes,F |
| 8/22/2021 | | | NHH | 8 | SCA | 7 | Tepera | Stashak | Quantrill | Stassi |
| 8/22/2021 | | | BEA | 2 | CCC | 12 | Nola,Aa | Paddack | Reid-Foley | Realmuto |
| 8/22/2021 | | | PAN | 4 | ISO | 8 | Wainwright | Dunn | | Seager,C |
| 8/22/2021 | | | CYC | 12 | LTR | 4 | Wilson,J | Taylor,Bl | Alexander,T | Bradley,J |
| 8/22/2021 | | | GOT | 8 | PHS | 11 | Rainey | Tanaka | Anderson,N | Higashioka |
| 8/22/2021 | | | BOM | 17 | WHC | 2 | Urias,J | Voth | Suter | Winker |
| 8/22/2021 | | | SEA | 2 | JOT | 1 | Carrasco | Castro,M | Bard,D | Hosmer |
| 8/22/2021 | | | ATK | 2 | COL | 4 | Lindblom | Skubal | Pagan | Turner,J |
| 8/22/2021 | | | NUT | 5 | LVB | 3 | Fedde | Cease | Dayton | Bohm |
| 8/23/2021 | | | PUR | 2 | JER | 15 | Weaver | Eshelman | | Candelario |
| 8/23/2021 | | | SMC | 5 | LAH | 1 | Anderson,I | Garcia,D | | Simmons |
| 8/23/2021 | | | PLU | 4 | HOU | 1 | Maeda | Gausman | Garcia,B | DeShields |
| 8/23/2021 | | | NHH | 4 | SCA | 1 | Ynoa | Wright | Quantrill | Kipnis |
| 8/23/2021 | | | BEA | 12 | CCC | 4 | Sanchez,An | Ryu | | Smith,WD |
| 8/23/2021 | | | PAN | 1 | ISO | 2 | Cobb | Musgrove | Antone | Betts |
| 8/23/2021 | | | CYC | 12 | LTR | 2 | Wilson,J | Lopez,P | | Bemboom |
| 8/23/2021 | | | GOT | 12 | PHS | 7 | Lester | Cueto | | Smith,Do |
| 8/23/2021 | | | BOM | 2 | WHC | 4 | Keller,B | Houser | Holland,G | Hoskins |
| 8/23/2021 | | | SEA | 4 | JOT | 8 | Alcantara,Sa | Fleming | James | Bader |
| 8/23/2021 | | | ATK | 6 | COL | 8 | Newsome | Tomlin | Pagan | Akiyama |
| 8/23/2021 | | | NUT | 9 | LVB | 5 | Perez,Ma | Castellani | | Fletcher,D |
| 8/24/2021 | | | PUR | 5 | JER | 7 | Maton | Hudson,Dak | Iglesias,R | Acuna |
| 8/24/2021 | | | SMC | 5 | LAH | 6 | Perez,O | Greene | Hendriks | Ramirez,J |
| 8/24/2021 | | | PLU | 5 | HOU | 6 | Buehler | Sanchez,S | Hahn | Tucker,K |
| 8/24/2021 | | | NHH | 4 | SCA | 6 | Cole,G | Brault | Montero | Yelich |
| 8/24/2021 | | | BEA | 7 | CCC | 4 | Bundy | Corbin | Jansen,K | |
| 8/24/2021 | | | PAN | 1 | ISO | 8 | Darvish | Lopez,J | | |
| 8/24/2021 | | | CYC | 6 | LTR | 3 | Heaney | Fiers | | Bradley,J |
| 8/24/2021 | | | GOT | 3 | PHS | 8 | Pena | Gray,S | Hernandez,D | Devers |
| 8/24/2021 | | | BOM | 0 | WHC | 2 | Plesac | deGrom | Sims | Mullins |
| 8/24/2021 | | | SEA | 6 | JOT | 2 | Bassitt | Bieber | | Braun |
| 8/24/2021 | | | ATK | 7 | COL | 5 | Fried | Greinke | Martin,C | Long |
| 8/24/2021 | | | NUT | 7 | LVB | 1 | Bauer | Stripling | | Calhoun,K |
| 8/26/2021 | | | CYC | 0 | GOT | 4 | Kershaw | Means | | Nola,Au |
| 8/26/2021 | | | SMC | 5 | NHH | 4 | Lugo,S | Quantrill | Melancon | Simmons |
| 8/26/2021 | | | PAN | 3 | ATK | 6 | Yarbrough | Matz | Williams,D | Franco |
| 8/26/2021 | | | BOM | 13 | PLU | 5 | Hendricks | Gonsolin | | LeMahieu |
| 8/26/2021 | | | BEA | 6 | SEA | 3 | Rosenthal | Plutko | Jansen,K | Cano |
| 8/26/2021 | | | PUR | 5 | NUT | 2 | Freeland | Senzatela | Jeffress | Dozier,H |
| 8/27/2021 | | | CYC | 1 | GOT | 5 | Alzolay | Gonzalez,G | | Aguilar |
| 8/27/2021 | | | SMC | 1 | NHH | 2 | Minor | Walker,T | Quantrill | Hays |
| 8/27/2021 | | 16 | PAN | 6 | ATK | 3 | Patino | Lorenzen | Turley | Robert |
| 8/27/2021 | | | BOM | 8 | PLU | 2 | Wheeler | Gibson | | |
| 8/27/2021 | | 11 | BEA | 3 | SEA | 4 | Stammen | Velasquez | | Marmolejos |
| 8/27/2021 | | | PUR | 7 | NUT | 1 | Canning | Javier | Finnegan | La Stella |
| 8/28/2021 | | | CYC | 4 | GOT | 5 | Rodriguez,Joe | Hunter | | Kepler |
| 8/28/2021 | | | SMC | 3 | NHH | 1 | Luzardo | Gray,J | Melancon | Kendrick |
| 8/28/2021 | | 11 | PAN | 5 | ATK | 4 | Wick | Webb,J | Patino | Munoz |
| 8/28/2021 | | | BOM | 5 | PLU | 1 | Urias,J | Davies | Hader | Dickerson,A |
| 8/28/2021 | | | BEA | 3 | SEA | 7 | Carrasco | Paddack | | Upton |
| 8/28/2021 | | | PUR | 4 | NUT | 5 | Dayton | Young,Al | | Aquino |
| 8/29/2021 | | | GOT | 4 | PAN | 0 | Lester | Dunn | Hernandez,J | Nunez,R |
| 8/29/2021 | | | CYC | 3 | ATK | 10 | Tomlin | Heaney | | Yastrzemski |
| 8/29/2021 | | | SMC | 1 | SEA | 3 | Bard,D | Greene | | Goodwin |
| 8/29/2021 | | | PLU | 1 | PUR | 0 | Glasnow | Eshelman | Garcia,B | Soler |
| 8/29/2021 | | | BOM | 7 | NUT | 4 | Houser | Yardley | Colome | Goldschmidt |
| 8/29/2021 | | | NHH | 7 | BEA | 3 | Ynoa | Sanchez,An | | Hays |
| 8/30/2021 | | | GOT | 8 | PAN | 2 | Gray,S | Musgrove | | Nunez,R |
| 8/30/2021 | | | CYC | 6 | ATK | 3 | Hunter | Fried | Pressly | Bradley,J |
| 8/30/2021 | | | SMC | 5 | SEA | 4 | Matzek | Bassitt | Melancon | d'Arnaud |
| 8/30/2021 | | | PLU | 3 | PUR | 2 | Garcia,Ja | Young,Al | Bass | Soler |
| 8/30/2021 | | | BOM | 1 | NUT | 2 | Dayton | Castillo,D | | Fletcher,D |
| 8/30/2021 | | | NHH | 8 | BEA | 4 | Brault | Bundy | | Urshela |
| 8/31/2021 | | | GOT | 2 | PAN | 6 | Lopez,J | Kershaw | Heuer | Rosario,A |
| 8/31/2021 | | | CYC | 5 | ATK | 8 | Webb,J | Means | Martin,C | Votto |
| 8/31/2021 | | | SMC | 6 | SEA | 9 | Kintzler | Ramirez,No | | Goodwin |
| 8/31/2021 | | | PLU | 4 | PUR | 6 | Freeland | Sanchez,S | Jeffress | Crawford,B |
| 8/31/2021 | | | BOM | 3 | NUT | 2 | Hendricks | Senzatela | Colome | Goldschmidt |
| 8/31/2021 | | | NHH | 0 | BEA | 1 | Jansen,K | Quantrill | | Flores,W |
| 9/2/2021 | | | JER | 0 | GOT | 7 | Green | Roark | | Grisham |
| 9/2/2021 | | | LAH | 7 | PAN | 2 | Woodruff | Matz | Dolis | Ramirez,J |
| 9/2/2021 | | | HOU | 6 | SEA | 4 | Armstrong | Kintzler | Hahn | Springer |
| 9/2/2021 | | 11 | SCA | 9 | ATK | 11 | Karinchak | Montero | | Votto |
| 9/2/2021 | | | CCC | 2 | PLU | 3 | Gonsolin | Richards,G | Scott | Soler |
| 9/2/2021 | | | ISO | 0 | NHH | 14 | Minor | Clevinger | | Wendle |
| 9/2/2021 | | | LTR | 5 | PUR | 2 | Lopez,P | Canning | | Cervelli |
| 9/2/2021 | | | PHS | 1 | NUT | 6 | Javier | Brubaker | | Bohm |
| 9/2/2021 | | | WHC | 8 | BEA | 6 | Keller,B | King,M | Holland,G | O'Neill |
| 9/2/2021 | | | JOT | 2 | BOM | 4 | Wheeler | Cabrera,G | Colome | Story |
| 9/2/2021 | | | COL | 5 | SMC | 11 | Walker,T | Lindblom | Lugo,S | d'Arnaud |
| 9/2/2021 | | | LVB | 9 | CYC | 5 | Garcia,LH | Strahm | | Goodrum |
| 9/3/2021 | | | JER | 2 | GOT | 10 | Tanaka | Montas | | Laureano |
| 9/3/2021 | | | LAH | 2 | PAN | 5 | Turley | Keuchel | Hudson,Dan | McNeil |
| 9/3/2021 | | | HOU | 1 | SEA | 5 | Carrasco | Gallen | Bard,D | Upton |
| 9/3/2021 | | | SCA | 3 | ATK | 6 | Skubal | Bubic | Graterol | Valaika |
| 9/3/2021 | | | CCC | 6 | PLU | 2 | Marquez,G | Gibson | | Hernandez,Ce |
| 9/3/2021 | | | ISO | 6 | NHH | 2 | Wainwright | Gray,J | | Contreras,WE |
| 9/3/2021 | | | LTR | 2 | PUR | 5 | Webb,L | Eflin | Jeffress | Crawford,B |
| 9/3/2021 | | | PHS | 1 | NUT | 0 | Giolito | Fedde | Anderson,N | Berti |
| 9/3/2021 | | | WHC | 2 | BEA | 5 | Pomeranz | Plesac | Rosenthal | Harper,B |
| 9/3/2021 | | | JOT | 4 | BOM | 8 | Urias,J | Flaherty | | Story |
| 9/3/2021 | | | COL | 4 | SMC | 2 | Greinke | Luzardo | Pagan | Turner,J |
| 9/3/2021 | | | LVB | 2 | CYC | 8 | Heaney | Cease | | Rosario,E |
| 9/4/2021 | | 10 | JER | 8 | GOT | 9 | Green | Iglesias,R | | Smith,Do |
| 9/4/2021 | | | LAH | 4 | PAN | 8 | Duffy | Castillo,L | | Smith,M |
| 9/4/2021 | | | HOU | 2 | SEA | 1 | Gausman | Fleming | Hahn | Springer |
| 9/4/2021 | | | SCA | 1 | ATK | 8 | Tomlin | Wright | Lorenzen | Solak |
| 9/4/2021 | | | CCC | 13 | PLU | 4 | Lynn | Davies | Reid-Foley | Rendon |
| 9/4/2021 | | | ISO | 4 | NHH | 8 | Tepera | DeSclafani | | Barnes,A |
| 9/4/2021 | | | LTR | 11 | PUR | 3 | Dobnak | Eshelman | | Hicks |
| 9/4/2021 | | | PHS | 4 | NUT | 3 | Rainey | Fairbanks | Anderson,N | Miller,B |
| 9/4/2021 | | | WHC | 3 | BEA | 4 | Sanchez,An | Sheffield | Jansen,K | |
| 9/4/2021 | | | JOT | 3 | BOM | 1 | Alcantara,Sa | Houser | Castro,M | Peralta,D |
| 9/4/2021 | | | COL | 5 | SMC | 4 | Kay | May,T | | |
| 9/4/2021 | | | LVB | 8 | CYC | 9 | Norris | Stripling | Pressly | Ahmed |
| 9/6/2021 | | | GOT | 2 | JER | 3 | Gonzalez,V | Gray,S | Iglesias,R | Crawford,JP |
| 9/6/2021 | | | PAN | 4 | LAH | 6 | Garcia,D | Dunn | Hendriks | Voit |
| 9/6/2021 | | 13 | SEA | 2 | HOU | 1 | Bard,D | Smyly | Baragar | Blackmon |
| 9/6/2021 | | | ATK | 8 | SCA | 4 | Fried | Wacha | | Long |
| 9/6/2021 | | | PLU | 0 | CCC | 10 | Nola,Aa | Glasnow | | Ozuna |
| 9/6/2021 | | | NHH | 6 | ISO | 4 | Allen,L | Antone | Quantrill | Conforto |
| 9/6/2021 | | | PUR | 4 | LTR | 5 | Peterson,D | Hudson,Dak | Webb,T | Cervelli |
| 9/6/2021 | | | NUT | 1 | PHS | 2 | Cody | Bauer | Anderson,N | Solano |
| 9/6/2021 | | | BEA | 5 | WHC | 4 | Fry,P | Holland,G | Jansen,K | Judge |
| 9/6/2021 | | | BOM | 1 | JOT | 2 | Castro,M | Castillo,D | | Murphy,S |
| 9/6/2021 | | | SMC | 12 | COL | 10 | Matzek | Newsome | Melancon | Abreu,J |
| 9/6/2021 | | | CYC | 5 | LVB | 6 | Stratton | Pressly | | Suarez,E |
| 9/7/2021 | | | GOT | 1 | JER | 2 | Valdez,F | Kershaw | Iglesias,R | Candelario |
| 9/7/2021 | | | PAN | 5 | LAH | 8 | Houck | Heuer | Hendriks | Ruf |
| 9/7/2021 | | | SEA | 9 | HOU | 12 | Burnes | Snell | Hahn | Springer |
| 9/7/2021 | | 12 | ATK | 5 | SCA | 6 | Cole,AJ | Martin,C | | Yelich |
| 9/7/2021 | | | PLU | 3 | CCC | 8 | Ryu | Maeda | | Cruz,N |
| 9/7/2021 | | | NHH | 4 | ISO | 8 | Antone | Barria | | Betts |
| 9/7/2021 | | | PUR | 3 | LTR | 4 | Duffey | Jeffress | | Rios,E |
| 9/7/2021 | | | NUT | 3 | PHS | 1 | Senzatela | Guerra,Ju | Dayton | Calhoun,K |
| 9/7/2021 | | | BEA | 3 | WHC | 4 | Suero | Rosenthal | | O'Neill |
| 9/7/2021 | | | BOM | 7 | JOT | 8 | Holland,D | Tate | Reyes,A | |
| 9/7/2021 | | | SMC | 4 | COL | 2 | Gonzales | Lindblom | Melancon | Anderson,Bri |
| 9/7/2021 | | | CYC | 7 | LVB | 8 | Garcia,LH | Strahm | | Kieboom |
| 9/8/2021 | | | GOT | 4 | JER | 14 | Allard | Alzolay | | Perez,S |
| 9/8/2021 | | | PAN | 7 | LAH | 4 | Trivino | Valdez,C | Hudson,Dan | Tapia,R |
| 9/8/2021 | | | SEA | 1 | HOU | 3 | Lamet | Mahle | Hahn | Tatis |
| 9/8/2021 | | | ATK | 3 | SCA | 1 | Montgomery,J | Boyd | Karinchak | McCann |
| 9/8/2021 | | | PLU | 9 | CCC | 3 | Sanchez,S | Corbin | Bass | Soler |
| 9/8/2021 | | | NHH | 5 | ISO | 4 | Minor | Clevinger | Quantrill | Barnes,A |
| 9/8/2021 | | | PUR | 12 | LTR | 3 | Canning | Lopez,P | | La Stella |
| 9/8/2021 | | | NUT | 5 | PHS | 20 | Brubaker | Javier | | Higashioka |
| 9/8/2021 | | | BEA | 0 | WHC | 6 | Plesac | Mize | | Stewart,C |
| 9/8/2021 | | | BOM | 5 | JOT | 4 | Wheeler | Bumgarner | Colome | Story |
| 9/8/2021 | | | SMC | 10 | COL | 4 | Lugo,S | Greinke | Ramirez,No | Abreu,J |
| 9/8/2021 | | | CYC | 4 | LVB | 3 | Wilson,J | Stratton | Pressly | Rosario,E |
| 9/9/2021 | | | GOT | 3 | PLU | 5 | Peralta,W | Hernandez,J | Garcia,B | Jeffers |
| 9/9/2021 | | | BOM | 6 | CYC | 5 | Hill,C | Almonte,Y | Romano,J | Story |
| 9/9/2021 | | | ATK | 7 | SMC | 2 | Skubal | Luzardo | Lorenzen | Valaika |
| 9/9/2021 | | | PAN | 3 | NHH | 5 | Gray,J | Matz | Quantrill | Frazier,T |
| 9/9/2021 | | 13 | SEA | 3 | NUT | 4 | Clarke | Kintzler | | Iglesias,J |
| 9/9/2021 | | | BEA | 3 | PUR | 4 | Finnegan | Rosenthal | Jeffress | Davis,JD |
| 9/10/2021 | | | GOT | 3 | PLU | 8 | Gibson | Lester | | Dickerson,C |
| 9/10/2021 | | | BOM | 2 | CYC | 0 | Houser | Norris | Hader | Goldschmidt |
| 9/10/2021 | | | ATK | 1 | SMC | 2 | Anderson,I | Tomlin | Melancon | Kendrick |
| 9/10/2021 | | | PAN | 6 | NHH | 8 | Smeltzer | Hudson,Dan | Quantrill | Wendle |
| 9/10/2021 | | | SEA | 7 | NUT | 4 | Hill,T | Fairbanks | Baragar | Ruiz,R |
| 9/10/2021 | | | BEA | 2 | PUR | 6 | Eshelman | Sanchez,An | | Davis,JD |
| 9/11/2021 | | | GOT | 6 | PLU | 5 | Gray,S | Davies | Green | Laureano |
| 9/11/2021 | | | BOM | 6 | CYC | 7 | Pressly | Castillo,D | | Gyorko |
| 9/11/2021 | | | ATK | 11 | SMC | 6 | Treinen | Melancon | | Gosselin |
| 9/11/2021 | | | PAN | 3 | NHH | 5 | Brault | Duffy | Quantrill | Margot |
| 9/11/2021 | | | SEA | 5 | NUT | 7 | Bauer | Bassitt | Fairbanks | Iglesias,J |
| 9/11/2021 | | | BEA | 8 | PUR | 7 | Rosenthal | Valdez,P | Jansen,K | |
| 9/12/2021 | | | ATK | 1 | SMC | 9 | Gonzales | Yarbrough | | Anderson,Bri |
| 9/12/2021 | | | PAN | 1 | NHH | 4 | Barria | Dunn | Kolarek | Wendle |
| 9/13/2021 | | | PLU | 2 | GOT | 4 | Kershaw | Glasnow | Green | Edman |
| 9/13/2021 | | | CYC | 1 | BOM | 3 | Hendricks | Heaney | Castillo,D | Goldschmidt |
| 9/13/2021 | | | SMC | 5 | ATK | 3 | Walker,T | Montgomery,J | Ramirez,No | Abreu,J |
| 9/13/2021 | | | NHH | 7 | PAN | 4 | Minor | Musgrove | Quantrill | Reyes,V |
| 9/13/2021 | | | NUT | 5 | SEA | 12 | Plutko | Neris | | Lowe,B |
| 9/13/2021 | | 11 | PUR | 13 | BEA | 9 | Scrubb | Lakins | | Grichuk |
| 9/14/2021 | | | PLU | 5 | GOT | 6 | Hernandez,J | Bass | Garrett,A | Grisham |
| 9/14/2021 | | 15 | CYC | 8 | BOM | 9 | Romano,J | Beeks | | Goldschmidt |
| 9/14/2021 | | 10 | SMC | 7 | ATK | 8 | Martin,C | Matzek | | Valaika |
| 9/14/2021 | | | NHH | 9 | PAN | 2 | Gray,J | Lopez,J | | Wendle |
| 9/14/2021 | | | NUT | 2 | SEA | 1 | Yardley | Plutko | Dayton | Aquino |
| 9/14/2021 | | | PUR | 11 | BEA | 10 | Canning | Mize | Valdez,P | Lopez,N |
| 9/15/2021 | | | PLU | 6 | GOT | 1 | Peralta,W | Hernandez,J | | Cooper |
| 9/15/2021 | | | CYC | 1 | BOM | 5 | Urias,J | Garrett,B | Hill,C | Brosseau |
| 9/15/2021 | | | SMC | 1 | ATK | 3 | Tomlin | Anderson,I | Martin,C | Yastrzemski |
| 9/15/2021 | | 10 | NHH | 6 | PAN | 7 | Hudson,Dan | Quantrill | | Harrison,J |
| 9/15/2021 | | | NUT | 0 | SEA | 2 | Carrasco | Fedde | Plutko | Goodwin |
| 9/15/2021 | | | PUR | 11 | BEA | 5 | Brasier | Paddack | | Lopez,N |
| 9/16/2021 | | | PUR | 5 | GOT | 2 | Scrubb | Lester | Jeffress | Davis,JD |
| 9/16/2021 | | | NUT | 5 | CYC | 4 | Neris | Pressly | Dayton | Sano |
| 9/16/2021 | | 13 | SMC | 6 | BOM | 5 | May,T | Hill,C | | Biggio |
| 9/16/2021 | | | PAN | 16 | BEA | 6 | Civale | Sanchez,An | | Munoz |
| 9/16/2021 | | | PLU | 1 | NHH | 7 | Quantrill | Rogers,Ty | | Guzman,R |
| 9/16/2021 | | 12 | SEA | 6 | ATK | 5 | Stammen | Treinen | | Marmolejos |
| 9/17/2021 | | 10 | PUR | 1 | GOT | 2 | Green | Young,Al | | Gregorius |
| 9/17/2021 | | | NUT | 6 | CYC | 1 | Bauer | Norris | | Calhoun,K |
| 9/17/2021 | | | SMC | 6 | BOM | 2 | Gonzales | deGrom | | Abreu,J |
| 9/17/2021 | | | PAN | 5 | BEA | 4 | Watson | Jansen,K | | Robert |
| 9/17/2021 | | | PLU | 10 | NHH | 8 | McKenzie | Allen,L | Garcia,B | Moncada |
| 9/17/2021 | | 11 | SEA | 0 | ATK | 1 | Martin,C | Baragar | | Yastrzemski |
| 9/18/2021 | | | PUR | 2 | GOT | 4 | Kershaw | Freeland | Rodriguez,Joe | |
| 9/18/2021 | | | NUT | 15 | CYC | 2 | Senzatela | Heaney | | Iglesias,J |
| 9/18/2021 | | | SMC | 5 | BOM | 8 | Hendricks | Ramirez,No | Wendelken | Schoop |
| 9/18/2021 | | 10 | PAN | 7 | BEA | 5 | Turley | Velasquez | Patino | McNeil |
| 9/18/2021 | | | PLU | 8 | NHH | 6 | Davies | Minor | McKenzie | Mejia,F |
| 9/18/2021 | | | SEA | 5 | ATK | 7 | Lorenzen | Kintzler | Anderson,C | Franco |
| 9/19/2021 | | | PUR | 9 | GOT | 11 | Barlow | Young,Al | | Nola,Au |
| 9/19/2021 | | | NUT | 9 | CYC | 5 | Javier | Gonzalez,G | Neris | Iglesias,J |
| 9/20/2021 | | | GOT | 18 | PUR | 1 | Tanaka | Webb,L | | Nola,Au |
| 9/20/2021 | | | CYC | 1 | NUT | 6 | Fedde | Garrett,B | | Romine,Au |
| 9/20/2021 | | | BOM | 3 | SMC | 1 | Wheeler | Luzardo | Colome | Goldschmidt |
| 9/20/2021 | | | BEA | 2 | PAN | 1 | Mize | Musgrove | Pomeranz | Flores,W |
| 9/20/2021 | | | NHH | 5 | PLU | 4 | Kolarek | Garcia,Ja | | Lewis |
| 9/20/2021 | | | ATK | 0 | SEA | 3 | Mahle | Skubal | Kintzler | Perez,Mi |
| 9/21/2021 | | | GOT | 7 | PUR | 2 | Lester | Eshelman | | Nola,Au |
| 9/21/2021 | | | CYC | 3 | NUT | 1 | Means | Perez,Ma | Pressly | Gurriel,Y |
| 9/21/2021 | | 14 | BOM | 2 | SMC | 3 | Loup | Castillo,D | | Abreu,J |
| 9/21/2021 | | | BEA | 4 | PAN | 5 | Cordero,J | Fry,P | | Harrison,J |
| 9/21/2021 | | | NHH | 12 | PLU | 2 | Ynoa | Maeda | Smeltzer | Kipnis |
| 9/21/2021 | | | ATK | 1 | SEA | 10 | Carrasco | Tomlin | | Ruiz,R |
| 9/22/2021 | | | GOT | 2 | PUR | 6 | Hudson,Dak | Gray,S | | Crawford,B |
| 9/22/2021 | | | CYC | 1 | NUT | 3 | Bauer | Tropeano | Dayton | Calhoun,K |
| 9/22/2021 | | | BOM | 4 | SMC | 3 | Houser | Berrios | Romano,J | Winker |
| 9/22/2021 | | | BEA | 7 | PAN | 2 | Sanchez,An | Matz | Jansen,K | Cano |
| 9/22/2021 | | | NHH | 4 | PLU | 5 | Sanchez,S | Tepera | Garcia,B | Marte,K |
| 9/22/2021 | | | ATK | 6 | SEA | 2 | Fried | Fleming | Williams,D | Valaika |
| 9/23/2021 | | | GOT | 6 | NHH | 5 | Kershaw | Barria | Green | Grisham |
| 9/23/2021 | | | CYC | 4 | SMC | 6 | Gonzales | Heaney | Ramirez,No | Abreu,J |
| 9/23/2021 | | | PAN | 5 | PUR | 2 | Civale | Freeland | Hudson,Dan | Munoz |
| 9/23/2021 | | | PLU | 3 | BEA | 9 | Bundy | Gonsolin | | Cano |
| 9/23/2021 | | | BOM | 5 | SEA | 4 | deGrom | Bassitt | Romano,J | Winker |
| 9/23/2021 | | | NUT | 7 | ATK | 0 | Senzatela | Yarbrough | | Fletcher,D |
| 9/24/2021 | | | GOT | 10 | NHH | 3 | Alzolay | Minor | Barlow | Edman |
| 9/24/2021 | | | CYC | 3 | SMC | 8 | Walker,T | Gonzalez,G | | Abreu,J |
| 9/24/2021 | | | PAN | 1 | PUR | 4 | Canning | Duffy | Jeffress | Gurriel,L |
| 9/24/2021 | | | PLU | 12 | BEA | 11 | Gibson | Porcello | Scott | Myers |
| 9/24/2021 | | | BOM | 7 | SEA | 4 | Hendricks | Snell | Hader | Story |
| 9/24/2021 | | 11 | NUT | 4 | ATK | 5 | Martin,C | Dayton | | Gonzalez,M |
| 9/25/2021 | | | GOT | 4 | NHH | 2 | Green | Quantrill | | Tauchman |
| 9/25/2021 | | | CYC | 5 | SMC | 8 | Luzardo | Alexander,T | Greene | Smith,P |
| 9/25/2021 | | | PAN | 2 | PUR | 7 | Webb,L | Dunn | | La Stella |
| 9/25/2021 | | | PLU | 5 | BEA | 7 | Lakins | Bass | Jansen,K | Judge |
| 9/25/2021 | | | BOM | 8 | SEA | 2 | Wheeler | Mahle | | Winker |
| 9/25/2021 | | | NUT | 7 | ATK | 6 | Fedde | Skubal | Clarke | Leon |
| 9/27/2021 | | | BEA | 8 | PLU | 3 | Paddack | Glasnow | Rosenthal | Chapman,M |
| 9/27/2021 | | | SEA | 2 | BOM | 9 | Urias,J | Carrasco | | Dickerson,A |
| 9/28/2021 | | | NHH | 7 | GOT | 5 | Kolarek | Lester | Tepera | Margot |
| 9/28/2021 | | | SMC | 8 | CYC | 3 | Anderson,I | Heaney | Loup | Calhoun,W |
| 9/28/2021 | | | PUR | 8 | PAN | 2 | Eshelman | Musgrove | | Gurriel,L |
| 9/28/2021 | | | BEA | 7 | PLU | 8 | Garcia,Ja | Jansen,K | | Soler |
| 9/28/2021 | | | SEA | 0 | BOM | 5 | Houser | Fleming | | Stallings |
| 9/28/2021 | | 10 | ATK | 5 | NUT | 6 | Clarke | Williams,D | | Iglesias,J |
| 9/29/2021 | | | NHH | 4 | GOT | 3 | Kolarek | Rodriguez,Joe | Quantrill | Barnes,A |
| 9/29/2021 | | | SMC | 4 | CYC | 6 | Means | Berrios | Pressly | Cabrera,M |
| 9/29/2021 | | | PUR | 2 | PAN | 1 | Finnegan | Hudson,Dan | Jeffress | Crawford,B |
| 9/29/2021 | | | BEA | 6 | PLU | 7 | Sanchez,S | Bundy | Scott | Bregman |
| 9/29/2021 | | | SEA | 3 | BOM | 4 | deGrom | Bassitt | Colome | Winker |
| 9/29/2021 | | 10 | ATK | 4 | NUT | 5 | Crichton | Treinen | | Fletcher,D |
| 9/30/2021 | | | NHH | 1 | GOT | 3 | Kershaw | Barria | Green | Pinder |
| 9/30/2021 | | | SMC | 8 | CYC | 2 | Gonzales | Gonzalez,G | Greene | Plawecki |
| 9/30/2021 | | | PUR | 12 | PAN | 4 | Freeland | Matz | | Severino |
| 9/30/2021 | | | BEA | 3 | PLU | 4 | Rogers,Ty | Velasquez | Scott | Bregman |
| 9/30/2021 | | | SEA | 5 | BOM | 8 | Suter | Snell | Colome | Story |
| 9/30/2021 | | | ATK | 0 | NUT | 4 | Senzatela | Yarbrough | | Iglesias,J |